KEGG   PATHWAY: dse04141
Entry
dse04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Drosophila sechellia
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
dse04141  Protein processing in endoplasmic reticulum
dse04141

Other DBs
GO: 0030433 0034976
Organism
Drosophila sechellia [GN:dse]
Gene
6613632  protein transport protein Sec61 subunit alpha [KO:K10956]
6609169  protein transport protein Sec61 subunit beta [KO:K09481]
6615029  protein transport protein Sec61 gamma-2 subunit [KO:K07342]
6608773  protein transport protein Sec61 gamma-1 subunit [KO:K07342]
6621600  translocation protein SEC62 isoform X1 [KO:K12275]
6611135  translocation protein SEC63 homolog [KO:K09540]
6611980  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
6609688  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
6619775  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
6619646  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
6615183  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
6611653  tumor suppressor candidate 3 [KO:K19478]
6613240  putative oligosaccharyltransferase complex subunit CG9662 [KO:K26501]
6606017  transmembrane protein 258 [KO:K26502]
6617655  mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
6619681  nucleotide exchange factor Sil1 [KO:K14001]
6619913  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
6614955  uncharacterized protein F54F2.9 [KO:K09521]
6607081  dnaJ homolog subfamily C member 3 [KO:K09523]
6618735  endoplasmin [KO:K09487]
6615251  neutral alpha-glucosidase AB [KO:K05546] [EC:3.2.1.207]
6614490  glucosidase 2 subunit beta [KO:K08288]
6612686  calnexin isoform X1 [KO:K08054]
6617947  LOW QUALITY PROTEIN: calnexin [KO:K08054]
6620204  LOW QUALITY PROTEIN: calnexin [KO:K08054]
6608724  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
6607076  calreticulin [KO:K08057]
6612778  mannosyl-oligosaccharide alpha-1,2-mannosidase IA [KO:K01230] [EC:3.2.1.113]
6617535  mannosyl-oligosaccharide alpha-1,2-mannosidase IA isoform X2 [KO:K01230] [EC:3.2.1.113]
6612651  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
6604895  protein ERGIC-53 [KO:K10080]
6613589  prolactin regulatory element-binding protein [KO:K14003]
6607401  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
6607568  protein SEC13 homolog [KO:K14004]
6608241  protein transport protein Sec31A isoform X3 [KO:K14005]
6614002  protein transport protein Sec23A isoform X1 [KO:K14006]
6613062  protein transport protein Sec24C [KO:K14007]
6608424  protein transport protein Sec24A [KO:K14007]
6618356  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
6616054  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
6617812  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
6605750  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
6613699  protein disulfide-isomerase A6 homolog [KO:K09584] [EC:5.3.4.1]
6609903  protein windbeutel [KO:K09586]
6617385  protein disulfide-isomerase 5-1 [KO:K13984] [EC:5.3.4.1]
6619901  thioredoxin domain-containing protein 5 homolog [KO:K13984] [EC:5.3.4.1]
6610730  ero1-like protein [KO:K10950] [EC:1.8.4.-]
6617697  endoplasmic reticulum lectin 1 [KO:K14008]
6617463  translocon-associated protein subunit alpha [KO:K13249]
6605878  translocon-associated protein subunit beta [KO:K13250]
6611878  translocon-associated protein subunit gamma [KO:K13251]
6608661  translocon-associated protein subunit delta [KO:K04571]
6610237  B-cell receptor-associated protein 31 isoform X1 [KO:K14009]
6615922  translocating chain-associated membrane protein 1 [KO:K14010]
6617428  derlin-1 [KO:K11519]
6616869  derlin-2 [KO:K13989]
6604796  UBX domain-containing protein 1 [KO:K24348]
6604794  UBX domain-containing protein 4 [KO:K24348]
6609832  UBX domain-containing protein 6 [KO:K14011]
6608001  NSFL1 cofactor p47 [KO:K14012]
6605004  small VCP/p97-interacting protein [KO:K14014]
6608439  transitional endoplasmic reticulum ATPase TER94 isoform X3 [KO:K13525]
6616939  nuclear protein localization protein 4 homolog isoform X1 [KO:K14015]
6605234  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
116801751  major heat shock 70 kDa protein Ba [KO:K03283]
6605619  heat shock 70 kDa protein cognate 1 [KO:K03283]
6606301  heat shock 70 kDa protein cognate 4 [KO:K03283]
6606753  major heat shock 70 kDa protein Ab [KO:K03283]
6606754  major heat shock 70 kDa protein Ab [KO:K03283]
6607674  heat shock protein 68 [KO:K03283]
6617803  dnaJ homolog subfamily A member 2 [KO:K09503]
6606451  dnaJ homolog subfamily B member 12 [KO:K09518]
6616546  dnaJ homolog subfamily C member 5 homolog isoform X1 [KO:K09525]
6605636  heat shock 70 kDa protein 4 isoform X2 [KO:K09485]
6605485  hsp70 nucleotide exchange factor fes1 [KO:K09562]
6615753  protein lethal(2)essential for life [KO:K09542]
6610852  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
6617352  phospholipase A-2-activating protein [KO:K14018]
6619451  UV excision repair protein RAD23 homolog A [KO:K10839]
6607677  UV excision repair protein RAD23 homolog B [KO:K10839]
6615039  ubiquilin-1 [KO:K04523]
6619145  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
6617789  ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
6613946  eukaryotic translation initiation factor 2-alpha kinase isoform X1 [KO:K08860] [EC:2.7.11.1]
6617942  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
6618271  uncharacterized protein LOC6618271 isoform X1 [KO:K04374]
6620659  LOW QUALITY PROTEIN: uncharacterized protein LOC6620659 [KO:K04374]
6620142  uncharacterized protein LOC6620142 isoform X1 [KO:K09054]
6607474  wolframin isoform X1 [KO:K14020]
6616478  membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
6608714  membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
6615310  LOW QUALITY PROTEIN: uncharacterized protein LOC6615310 [KO:K09027]
6619027  mitogen-activated protein kinase kinase kinase 15 [KO:K04426] [EC:2.7.11.25]
6618620  dual specificity mitogen-activated protein kinase kinase hemipterous isoform X1 [KO:K04431] [EC:2.7.12.2]
6611938  stress-activated protein kinase JNK [KO:K04440] [EC:2.7.11.24]
6610477  E3 ubiquitin-protein ligase MARCH6 [KO:K10661] [EC:2.3.2.27]
6616741  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
6606487  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
6620431  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
6617957  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
6619529  E3 ubiquitin-protein ligase HRD1 [KO:K10601] [EC:2.3.2.27]
6619982  E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
6607620  protein sel-1 homolog 1 [KO:K14026]
6612005  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
6606359  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
6610651  uncharacterized protein LOC6610651 [KO:K06689] [EC:2.3.2.23]
6616405  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
6610179  RING-box protein 1B [KO:K03868] [EC:2.3.2.32]
6615886  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
6605519  cullin-1 [KO:K03347]
6608075  cullin homolog 1 [KO:K03347]
6615714  S-phase kinase-associated protein 1 [KO:K03094]
116801228  S-phase kinase-associated protein 1 [KO:K03094]
6608758  S-phase kinase-associated protein 1 [KO:K03094]
6615063  S-phase kinase-associated protein 1 [KO:K03094]
6615888  S-phase kinase-associated protein 1 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
dse00510  N-Glycan biosynthesis
dse03050  Proteasome
dse03060  Protein export
KO pathway
ko04141   
LinkDB

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