KEGG   PATHWAY: dsp00260
Entry
dsp00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Dipodomys spectabilis (banner-tailed kangaroo rat)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
dsp00260  Glycine, serine and threonine metabolism
dsp00260

Module
dsp_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:dsp00260]
dsp_M00047  Creatine pathway [PATH:dsp00260]
dsp_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:dsp00260]
dsp_M00555  Betaine biosynthesis, choline => betaine [PATH:dsp00260]
dsp_M00621  Glycine cleavage system [PATH:dsp00260]
dsp_M00974  Betaine metabolism, animals, betaine => glycine [PATH:dsp00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Dipodomys spectabilis (banner-tailed kangaroo rat) [GN:dsp]
Gene
122096601  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
122097898  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
122124166  Shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
122103227  Shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
122115671  Agxt; serine--pyruvate aminotransferase isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
122122992  Grhpr; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
122095721  Glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
122128051  Pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
122115715  Pgam1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
122099556  Bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
122125320  bisphosphoglycerate mutase-like isoform X1 [KO:K01837] [EC:5.4.2.4 5.4.2.11]
122110924  Phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122095117  Psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
122114817  Psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
122119129  Gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
122095701  Alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
122112013  Alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
122110911  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
122110938  Maob; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
122103597  membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
122103201  Aoc3; membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
122113638  Gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
122095550  Amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
122111855  Dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
122126142  Gcsh; glycine cleavage system H protein, mitochondrial [KO:K02437]
122102679  Dao; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
122116999  Agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122114389  Gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
122122772  Gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
122107995  Chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
122103983  Aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
122117199  Bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
122117211  Dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
122119191  Pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
122108903  Sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
122101636  glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
122114243  Cbs; cystathionine beta-synthase-like protein isoform X1 [KO:K01697] [EC:4.2.1.22]
122112414  Cth; cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
122098550  Sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
122098567  Sds; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
122100463  Srr; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
dsp00010  Glycolysis / Gluconeogenesis
dsp00020  Citrate cycle (TCA cycle)
dsp00230  Purine metabolism
dsp00250  Alanine, aspartate and glutamate metabolism
dsp00270  Cysteine and methionine metabolism
dsp00290  Valine, leucine and isoleucine biosynthesis
dsp00330  Arginine and proline metabolism
dsp00470  D-Amino acid metabolism
dsp00564  Glycerophospholipid metabolism
dsp00600  Sphingolipid metabolism
dsp00620  Pyruvate metabolism
dsp00630  Glyoxylate and dicarboxylate metabolism
dsp00640  Propanoate metabolism
dsp00860  Porphyrin metabolism
dsp00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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