KEGG   PATHWAY: eee04142
Entry
eee04142                    Pathway                                
Name
Lysosome - Electrophorus electricus (electric eel)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
eee04142  Lysosome
eee04142

Other DBs
GO: 0005764
Organism
Electrophorus electricus (electric eel) [GN:eee]
Gene
113591826  atp6v0a2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
113584812  V-type proton ATPase 116 kDa subunit a-like isoform X1 [KO:K02154]
113589966  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
113571496  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
113583015  V-type proton ATPase 116 kDa subunit a-like [KO:K02154]
113571921  atp6v0a1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
113582734  atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
113589420  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
113581385  V-type proton ATPase subunit S1-like isoform X1 [KO:K03662]
113572318  atp6ap1; V-type proton ATPase subunit S1 [KO:K03662]
113580241  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
113567768  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
113584666  atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
113571006  dmxl1; dmX-like protein 1 isoform X1 [KO:K24155]
113577294  dmxl2; dmX-like protein 2 isoform X1 [KO:K24155]
113573739  wdr7; WD repeat-containing protein 7 [KO:K24738]
113571941  nuclear receptor coactivator 7-like isoform X1 [KO:K25442]
113588061  nuclear receptor coactivator 7-like [KO:K25442]
113571584  ctsa; lysosomal protective protein isoform X1 [KO:K13289] [EC:3.4.16.5]
113569846  lysosomal protective protein-like [KO:K13289] [EC:3.4.16.5]
113571882  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
113583676  ctsb; cathepsin B [KO:K01363] [EC:3.4.22.1]
113578742  ctsc; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
113583729  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
113592030  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
113573545  cathepsin E-like [KO:K01382] [EC:3.4.23.34]
113573387  ctsf; cathepsin F [KO:K01373] [EC:3.4.22.41]
113573981  ctsh; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
113575274  cathepsin K-like [KO:K01371] [EC:3.4.22.38]
113585755  cathepsin L1-like [KO:K01371] [EC:3.4.22.38]
113589718  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
113567712  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
113574513  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
113576047  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
113579932  ctso; cathepsin O [KO:K01374] [EC:3.4.22.42]
113590155  cathepsin L1-like [KO:K01368] [EC:3.4.22.27]
113575272  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
113577871  ctsz; cathepsin Z [KO:K08568] [EC:3.4.18.1]
113584551  legumain-like isoform X1 [KO:K01369] [EC:3.4.22.34]
113574748  lgmn; legumain [KO:K01369] [EC:3.4.22.34]
113576644  tpp1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
113583860  glb1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
113573276  gaa; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
113574921  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
113570698  gba; glucosylceramidase [KO:K01201] [EC:3.2.1.45]
113589884  idua; alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
113578116  naga; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
113583776  naglu; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
113579786  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
113570357  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
113577548  gusb; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
113575058  tissue alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
113572634  fuca2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
113575085  tissue alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
113573725  hexb; beta-hexosaminidase subunit beta isoform X1 [KO:K12373] [EC:3.2.1.52]
113573104  beta-hexosaminidase subunit alpha-like [KO:K12373] [EC:3.2.1.52]
113585864  manba; beta-mannosidase [KO:K01192] [EC:3.2.1.25]
113589666  man2b1; lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
113583409  neu1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
113583410  sialidase-1-like isoform X1 [KO:K01186] [EC:3.2.1.18]
113582166  hyaluronidase PH-20-like [KO:K01197] [EC:3.2.1.35]
113582602  hyaluronidase PH-20-like [KO:K01197] [EC:3.2.1.35]
113583824  hyaluronidase-2-like [KO:K01197] [EC:3.2.1.35]
113583177  hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
113575841  hyaluronidase-3-like [KO:K01197] [EC:3.2.1.35]
113575871  hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
113571567  hyaluronidase-2-like [KO:K01197] [EC:3.2.1.35]
113568061  hyaluronidase-5-like [KO:K01197] [EC:3.2.1.35]
113571631  hyaluronidase-1-like isoform X1 [KO:K01197] [EC:3.2.1.35]
113580520  arsa; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
113590451  arsb; arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
113574855  arsg; arylsulfatase G isoform X1 [KO:K12381] [EC:3.1.6.-]
113575705  galns; N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
113583834  N-acetylglucosamine-6-sulfatase-like [KO:K01137] [EC:3.1.6.14]
113580978  gns; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
113572503  ids; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
113585727  sgsh; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
113579473  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
113581796  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
113571916  deoxyribonuclease-2-alpha-like [KO:K01158] [EC:3.1.22.1]
113581922  dnase2b; deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
113577696  acp2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
113581278  tartrate-resistant acid phosphatase type 5-like [KO:K14379] [EC:3.1.3.2]
113588799  acp5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
113581190  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
113579253  acid ceramidase-like isoform X1 [KO:K12348] [EC:3.5.1.23]
113591369  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
113579936  aga; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
113582046  uncharacterized protein LOC113582046 [KO:K01444] [EC:3.5.1.26]
113585694  psap; prosaposin isoform X1 [KO:K12382]
113581612  prosaposin-like [KO:K12382]
113583005  prosaposin-like [KO:K12382]
113573404  gm2a; ganglioside GM2 activator [KO:K12383]
113586395  lysosomal thioesterase PPT2-like [KO:K01074] [EC:3.1.2.22]
113578429  ppt1; palmitoyl-protein thioesterase 1 isoform X1 [KO:K01074] [EC:3.1.2.22]
113589076  ppt2; lysosomal thioesterase PPT2 isoform X1 [KO:K01074] [EC:3.1.2.22]
113576835  lamp1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
113582653  lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
113574344  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
113577832  lamp3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
113584708  macrosialin-like isoform X1 [KO:K06501]
113587251  cd63; CD63 antigen [KO:K06497]
113591678  lysosome membrane protein 2-like [KO:K12384]
113572909  scarb2; lysosome membrane protein 2 isoform X1 [KO:K12384]
113568671  lysosome membrane protein 2-like [KO:K12384]
113590800  npc1; LOW QUALITY PROTEIN: NPC intracellular cholesterol transporter 1 [KO:K12385]
113583308  npc2; NPC intracellular cholesterol transporter 2 [KO:K13443]
113574465  ctns; cystinosin isoform X1 [KO:K12386]
113580294  slc17a5; sialin [KO:K12301]
113578441  sialin-like isoform X1 [KO:K12301]
113572426  natural resistance-associated macrophage protein 2-like [KO:K21398]
113570903  laptm4a; lysosomal-associated transmembrane protein 4A [KO:K12387]
113575059  lysosomal-associated transmembrane protein 4B-like [KO:K12387]
113576054  laptm4b; lysosomal-associated transmembrane protein 4B [KO:K12387]
113588362  lysosomal-associated transmembrane protein 4A-like [KO:K12387]
113572897  abca2; ATP-binding cassette sub-family A member 2 [KO:K05642]
113589568  abcb9; ATP-binding cassette sub-family B member 9 [KO:K05656]
113580772  cd164; sialomucin core protein 24 [KO:K06546]
113578168  entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
113578937  sort1; sortilin [KO:K12388]
113575543  sortilin-like [KO:K12388]
113579988  sortilin-like isoform X1 [KO:K12388]
113592053  cln3; battenin isoform X1 [KO:K12389]
113579019  cln5; ceroid-lipofuscinosis neuronal protein 5 isoform X1 [KO:K12390]
113585748  major facilitator superfamily domain-containing protein 8-like [KO:K12307]
113570155  major facilitator superfamily domain-containing protein 8-like [KO:K12307]
113584169  mfsd8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
113585225  heparan-alpha-glucosaminide N-acetyltransferase-like [KO:K10532] [EC:2.3.1.78]
113591477  hgsnat; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
113575976  sumf1; formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
113587996  gnptab; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
113583366  gnptg; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
113573175  nagpa; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
113570044  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
113575279  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
113568450  clta; clathrin light chain A isoform X1 [KO:K04644]
113580085  cltb; clathrin light chain B isoform X1 [KO:K04645]
113584373  clathrin heavy chain 1 isoform X1 [KO:K04646]
113584900  clathrin heavy chain 1-like [KO:K04646]
113584925  clathrin heavy chain 1-like isoform X1 [KO:K04646]
113589198  AP-1 complex subunit gamma-1-like [KO:K12391]
113575755  ap1g1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
113574976  LOW QUALITY PROTEIN: AP-1 complex subunit beta-1-like [KO:K12392]
113570480  AP-1 complex subunit mu-2-like isoform X1 [KO:K12393]
113579478  ap1m2; AP-1 complex subunit mu-2 [KO:K12393]
113582876  ap1m1; AP-1 complex subunit mu-1 [KO:K12393]
113575417  AP-1 complex subunit sigma-2-like [KO:K12394]
113570333  AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
113580819  AP-1 complex subunit sigma-1A isoform X1 [KO:K12394]
113567836  AP-1 complex subunit sigma-3-like isoform X1 [KO:K12395]
113587007  ap1s3; AP-1 complex subunit sigma-3 [KO:K12395]
113588940  ap3d1; AP-3 complex subunit delta-1 [KO:K12396]
113571413  ap3b2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
113583960  AP-3 complex subunit beta-1-like [KO:K12397]
113582051  AP-3 complex subunit mu-1 [KO:K12398]
113587358  AP-3 complex subunit mu-2 isoform X1 [KO:K12398]
113590797  ap3s2; AP-3 complex subunit sigma-2 [KO:K12399]
113571027  ap3s1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
113584484  ap4e1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
113587800  ap4b1; AP-4 complex subunit beta-1 [KO:K12401]
113590925  ap4m1; AP-4 complex subunit mu-1 [KO:K12402]
113571423  ap4s1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
113585192  ADP-ribosylation factor-binding protein GGA3-like isoform X1 [KO:K12404]
113567678  ADP-ribosylation factor-binding protein GGA3-like [KO:K12404]
113584088  gga1; ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
113584790  ADP-ribosylation factor-binding protein GGA3-like isoform X1 [KO:K12404]
113584857  mucolipin-1-like [KO:K04992]
113580333  mcoln1; mucolipin-1 [KO:K04992]
113575184  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
113591192  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
113588344  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
113574926  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
113572442  snrnp25; U11/U12 small nuclear ribonucleoprotein 25 kDa protein isoform X1 [KO:K19363]
113574816  uncharacterized protein LOC113574816 [KO:K19363]
113572851  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
eee00511  Other glycan degradation
eee00531  Glycosaminoglycan degradation
eee04130  SNARE interactions in vesicular transport
eee04140  Autophagy - animal
eee04144  Endocytosis
KO pathway
ko04142   
LinkDB

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