KEGG   PATHWAY: elk04142
Entry
elk04142                    Pathway                                
Name
Lysosome - Enhydra lutris kenyoni (northern sea otter)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
elk04142  Lysosome
elk04142

Other DBs
GO: 0005764
Organism
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
Gene
111151299  V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
111151992  V-type proton ATPase 116 kDa subunit a [KO:K02154]
111156406  V-type proton ATPase 116 kDa subunit a [KO:K02154]
111150062  V-type proton ATPase 116 kDa subunit a [KO:K02154]
111146695  V-type proton ATPase subunit d 2 [KO:K02146]
111152837  V-type proton ATPase subunit d 1 [KO:K02146]
111155413  V-type proton ATPase subunit H isoform X1 [KO:K02144]
111139189  V-type proton ATPase subunit S1 [KO:K03662]
111156039  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
111143472  V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
111158846  dmX-like protein 1 isoform X1 [KO:K24155]
111160078  dmX-like protein 2 isoform X1 [KO:K24155]
111154249  WD repeat-containing protein 7 isoform X1 [KO:K24738]
111147585  nuclear receptor coactivator 7 isoform X1 [KO:K25442]
111141795  lysosomal protective protein isoform X1 [KO:K13289] [EC:3.4.16.5]
111154231  cathepsin B [KO:K01363] [EC:3.4.22.1]
111154405  dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
111149567  cathepsin D [KO:K01379] [EC:3.4.23.5]
111151129  cathepsin E [KO:K01382] [EC:3.4.23.34]
111149512  cathepsin F isoform X1 [KO:K01373] [EC:3.4.22.41]
111162031  cathepsin G-like [KO:K01319] [EC:3.4.21.20]
111152563  pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
111161944  cathepsin K isoform X1 [KO:K01371] [EC:3.4.22.38]
111139087  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
111139090  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
111139097  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
111153605  LOW QUALITY PROTEIN: cathepsin L1 [KO:K01365] [EC:3.4.22.15]
111152861  cathepsin O [KO:K01374] [EC:3.4.22.42]
111162017  cathepsin S [KO:K01368] [EC:3.4.22.27]
111150040  cathepsin W [KO:K08569] [EC:3.4.22.-]
111141946  cathepsin Z [KO:K08568] [EC:3.4.18.1]
111160829  napsin-A [KO:K08565] [EC:3.4.23.-]
111148711  legumain [KO:K01369] [EC:3.4.22.34]
111159341  tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
111159184  alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
111159077  beta-galactosidase [KO:K12309] [EC:3.2.1.23]
111160434  lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
111138892  glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
111148996  alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
111157598  alpha-N-acetylgalactosaminidase isoform X1 [KO:K01204] [EC:3.2.1.49]
111151541  LOW QUALITY PROTEIN: alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
111148622  galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
111146340  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
111154680  tissue alpha-L-fucosidase isoform X1 [KO:K01206] [EC:3.2.1.51]
111147647  plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
111148238  beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
111153259  beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
111154592  beta-mannosidase [KO:K01192] [EC:3.2.1.25]
111162426  lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
111152263  sialidase-1 [KO:K01186] [EC:3.2.1.18]
111151847  hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
111151911  hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
111151913  hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
111144346  hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
111144050  hyaluronidase-1 isoform X1 [KO:K01197] [EC:3.2.1.35]
111152116  LOW QUALITY PROTEIN: hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
111143952  hyaluronidase-3 isoform X1 [KO:K01197] [EC:3.2.1.35]
111157535  arylsulfatase A isoform X1 [KO:K01134] [EC:3.1.6.8]
111148285  arylsulfatase B [KO:K01135] [EC:3.1.6.12]
111158150  arylsulfatase G [KO:K12381] [EC:3.1.6.-]
111152803  N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
111142205  N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
111158976  iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
111160442  N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
111144939  lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
111152901  group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
111162495  deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
111143520  deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
111150114  lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
111162467  tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
111159436  sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
111144609  acid ceramidase [KO:K12348] [EC:3.5.1.23]
111144601  N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1 [KO:K01444] [EC:3.5.1.26]
111144740  prosaposin isoform X1 [KO:K12382]
111140986  ganglioside GM2 activator [KO:K12383]
111143013  palmitoyl-protein thioesterase 1 isoform X1 [KO:K01074] [EC:3.1.2.22]
111146989  lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
111157273  lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
111150860  lysosome-associated membrane glycoprotein 3 isoform X1 [KO:K06562]
111161115  macrosialin isoform X1 [KO:K06501]
111160150  CD63 antigen [KO:K06497]
111149179  lysosome membrane protein 2 isoform X1 [KO:K12384]
111142703  Niemann-Pick C1 protein-like [KO:K12385]
111142399  Niemann-Pick C1 protein [KO:K12385]
111148568  epididymal secretory protein E1 [KO:K13443]
111158772  cystinosin isoform X1 [KO:K12386]
111152377  sialin isoform X1 [KO:K12301]
111143491  natural resistance-associated macrophage protein 1 [KO:K12347]
111157824  natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
111154125  lysosomal-associated transmembrane protein 4A [KO:K12387]
111143237  lysosomal-associated transmembrane protein 5 isoform X1 [KO:K12387]
111146492  LOW QUALITY PROTEIN: lysosomal-associated transmembrane protein 4B [KO:K12387]
111145667  ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
111156457  ATP-binding cassette sub-family B member 9 [KO:K05656]
111158283  sialomucin core protein 24 isoform X1 [KO:K06546]
111156836  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
111143153  sortilin isoform X1 [KO:K12388]
111162300  battenin [KO:K12389]
111146993  ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
111154992  major facilitator superfamily domain-containing protein 8 [KO:K12307]
111144416  heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
111143975  sulfatase-modifying factor 1 isoform X1 [KO:K13444] [EC:1.8.3.7]
111142162  N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239] [EC:2.7.8.17]
111155975  N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
111156230  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
111158747  cation-independent mannose-6-phosphate receptor [KO:K06564]
111141965  cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
111145614  clathrin light chain A isoform X1 [KO:K04644]
111140858  clathrin light chain B isoform X1 [KO:K04645]
111142671  clathrin heavy chain 2 [KO:K04646]
111151260  clathrin heavy chain 1 isoform X1 [KO:K04646]
111138893  AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
111152802  AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
111160028  AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
111162523  AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
111144152  AP-1 complex subunit mu-1 isoform X1 [KO:K12393]
111139455  AP-1 complex subunit sigma-2-like [KO:K12394]
111146117  AP-1 complex subunit sigma-1A [KO:K12394]
111157096  AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
111139355  AP-1 complex subunit sigma-3 [KO:K12395]
111161660  AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
111152627  LOW QUALITY PROTEIN: AP-3 complex subunit beta-2 [KO:K12397]
111148283  AP-3 complex subunit beta-1 [KO:K12397]
111144800  AP-3 complex subunit mu-1 isoform X1 [KO:K12398]
111144485  AP-3 complex subunit mu-2 [KO:K12398]
111152579  AP-3 complex subunit sigma-2 isoform X1 [KO:K12399]
111158910  AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
111138820  AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
111142873  AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
111146166  AP-4 complex subunit mu-1 [KO:K12402]
111158541  AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
111160300  ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
111157508  ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
111162342  ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
111161850  mucolipin-1 isoform X1 [KO:K04992]
111156021  lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
111156167  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1 [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
elk00511  Other glycan degradation
elk00531  Glycosaminoglycan degradation
elk04130  SNARE interactions in vesicular transport
elk04140  Autophagy - animal
elk04144  Endocytosis
KO pathway
ko04142   
LinkDB

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