KEGG   PATHWAY: epa00600
Entry
epa00600                    Pathway                                
Name
Sphingolipid metabolism - Exaiptasia diaphana (Aiptasia)
Class
Metabolism; Lipid metabolism
Pathway map
epa00600  Sphingolipid metabolism
epa00600

Module
epa_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:epa00600]
epa_M00094  Ceramide biosynthesis [PATH:epa00600]
epa_M00099  Sphingosine biosynthesis [PATH:epa00600]
epa_M00100  Sphingosine degradation [PATH:epa00600]
Other DBs
GO: 0006665
Organism
Exaiptasia diaphana (Aiptasia) [GN:epa]
Gene
110234734  serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
110235681  serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
110248773  3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
110240089  ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
110239732  ceramide synthase 5 [KO:K23727] [EC:2.3.1.291]
110239328  ceramide synthase 6 [KO:K23727] [EC:2.3.1.291]
110240322  acid ceramidase [KO:K12348] [EC:3.5.1.23]
110243075  alkaline ceramidase [KO:K01441] [EC:3.5.1.23]
110231299  sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
110240339  sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
110237104  sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
110253965  putative neutral sphingomyelinase [KO:K12351] [EC:3.1.4.12]
110237461  ceramide kinase [KO:K04715] [EC:2.7.1.138]
110236735  ceramide kinase [KO:K04715] [EC:2.7.1.138]
110235182  phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
110235191  phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
110236819  phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
110243877  sphingosine-1-phosphate phosphatase 2 [KO:K04716] [EC:3.1.3.-]
110238851  ceramide phosphoethanolamine synthase [KO:K26283] [EC:2.7.8.48]
110243462  sphingosine-1-phosphate phosphatase 2 [KO:K23451] [EC:3.1.3.-]
110253867  sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
110253868  sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
110242290  sphingosine-1-phosphate lyase 1 [KO:K01634] [EC:4.1.2.27]
110255067  ceramide glucosyltransferase-B [KO:K00720] [EC:2.4.1.80]
110253423  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
110253424  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
110253615  non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
110252569  uncharacterized protein LOC110252569 [KO:K17108] [EC:3.2.1.45]
110243550  beta-galactosidase [KO:K12309] [EC:3.2.1.23]
110231822  2-hydroxyacylsphingosine 1-beta-galactosyltransferase isoform X2 [KO:K04628] [EC:2.4.1.47]
110231830  UDP-glucuronosyltransferase 1-2-like [KO:K04628] [EC:2.4.1.47]
110242043  2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
110243724  UDP-glucuronosyltransferase 3A1 [KO:K04628] [EC:2.4.1.47]
110253573  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
110237530  galactose-3-O-sulfotransferase 2 [KO:K01019] [EC:2.8.2.11]
110251001  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
110253453  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
110250538  uncharacterized protein LOC110250538 [KO:K12373] [EC:3.2.1.52]
110250541  uncharacterized protein LOC110250541 [KO:K12373] [EC:3.2.1.52]
110250559  uncharacterized protein LOC110250559 [KO:K12373] [EC:3.2.1.52]
110239366  uncharacterized protein LOC110239366 [KO:K12373] [EC:3.2.1.52]
110236420  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
110237708  uncharacterized protein LOC110237708 isoform X1 [KO:K12373] [EC:3.2.1.52]
110254552  ganglioside GM2 activator [KO:K12383]
110248108  ganglioside GM2 activator [KO:K12383]
110254068  uncharacterized protein LOC110254068 [KO:K12383]
110254106  uncharacterized protein LOC110254106 [KO:K12383]
110232979  prosaposin-like [KO:K12382]
110232999  prosaposin-like [KO:K12382]
110240302  prosaposin [KO:K12382]
110240311  prosaposin [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
epa00260  Glycine, serine and threonine metabolism
epa00603  Glycosphingolipid biosynthesis - globo and isoglobo series
epa00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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