Entry Name Oocyte meiosis - Gymnodraco acuticeps
Description During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segregate to opposite poles, while the sister chromatids segregate from each other at meoisis II. In vertebrates, immature oocytes are arrested at the PI (prophase of meiosis I). The resumption of meiosis is stimulated by progesterone, which carries the oocyte through two consecutive M-phases (MI and MII) to a second arrest at MII. The key activity driving meiotic progression is the MPF (maturation-promoting factor), a heterodimer of CDC2 (cell division cycle 2 kinase) and cyclin B. In PI-arrested oocytes, MPF is initially inactive and is activated by the dual-specificity CDC25C phosphatase as the result of new synthesis of Mos induced by progesterone. MPF activation mediates the transition from the PI arrest to MI. The subsequent decrease in MPF levels, required to exit from MI into interkinesis, is induced by a negative feedback loop, where CDC2 brings about the activation of the APC (anaphase-promoting complex), which mediates destruction of cyclin B. Re-activation of MPF for MII requires re-accumulation of high levels of cyclin B as well as the inactivation of the APC by newly synthesized Emi2 and other components of the CSF (cytostatic factor), such as cyclin E or high levels of Mos. CSF antagonizes the ubiquitin ligase activity of the APC, preventing cyclin B destruction and meiotic exit until fertilization occurs. Fertilization triggers a transient increase in cytosolic free Ca2+, which leads to CSF inactivation and cyclin B destruction through the APC. Then eggs are released from MII into the first embryonic cell cycle.
Class Cellular Processes; Cell growth and deathBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Gymnodraco acuticeps [GN:
gacu ]
Gene 117551081 cpeb3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602 ]
117545222 cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602 ]
117540169 cpeb4b; cytoplasmic polyadenylation element-binding protein 4b isoform X1 [KO:K02602 ]
117549271 cpeb1b; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602 ]
117544997 pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633 ] [EC:2.7.11.1 ]
117539053 ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A isoform X1 [KO:K06269 ] [EC:3.1.3.16 ]
117551767 ccnp; cyclin N-terminal domain-containing protein 2 isoform X1 [KO:K21770 ]
117551805 cth1; LOW QUALITY PROTEIN: cysteine three histidine 1 [KO:K13056 ]
117555793 fbxw11a; F-box/WD repeat-containing protein 11a isoform X1 [KO:K03362 ]
117560796 anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348 ]
117535702 cdc27; LOW QUALITY PROTEIN: cell division cycle protein 27 homolog [KO:K03350 ]
117559877 anapc4; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 4 [KO:K03351 ]
117544006 anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352 ]
117541010 LOW QUALITY PROTEIN: meiotic recombination protein REC8 homolog [KO:K13054 ]
117539398 smc1b; structural maintenance of chromosomes protein 1B [KO:K06636 ]
117541825 smc1a; structural maintenance of chromosomes protein 1A [KO:K06636 ]
117561675 smc3; structural maintenance of chromosomes protein 3 isoform X1 [KO:K06669 ]
117547265 mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537 ]
117540350 mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728 ]
117555339 mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679 ]
117550376 ppp2r5b; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584 ]
117540535 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584 ]
117554271 ppp2r5cb; LOW QUALITY PROTEIN: protein phosphatase 2, regulatory subunit B', gamma b [KO:K11584 ]
117556388 ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584 ]
117562327 ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584 ]
117552197 ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456 ]
117540167 ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
117538959 LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1-like [KO:K05861 ] [EC:3.1.4.11 ]
117543700 itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
117551047 LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958 ]
117552612 LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960 ]
117536300 LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960 ]
117552299 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
117534709 ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
117536359 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
117544304 LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515 ] [EC:2.7.11.17 ]
117543393 camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
117560739 camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Haccard O, Jessus C
Title Oocyte maturation, Mos and cyclins--a matter of synthesis: two functionally redundant ways to induce meiotic maturation.
Journal Reference Authors Crane R, Gadea B, Littlepage L, Wu H, Ruderman JV
Title Aurora A, meiosis and mitosis.
Journal Reference Authors Perdiguero E, Nebreda AR
Title Regulation of Cdc25C activity during the meiotic G2/M transition.
Journal Reference Authors Perry JA, Kornbluth S
Title Cdc25 and Wee1: analogous opposites?
Journal Reference Authors Jessus C, Ozon R
Title How does Xenopus oocyte acquire its competence to undergo meiotic maturation?
Journal Reference Authors Revenkova E, Jessberger R
Title Shaping meiotic prophase chromosomes: cohesins and synaptonemal complex proteins.
Journal Reference Authors Belloc E, Pique M, Mendez R
Title Sequential waves of polyadenylation and deadenylation define a translation circuit that drives meiotic progression.
Journal Reference Authors Pesin JA, Orr-Weaver TL
Title Regulation of APC/C activators in mitosis and meiosis.
Journal Reference Authors Tang W, Wu JQ, Guo Y, Hansen DV, Perry JA, Freel CD, Nutt L, Jackson PK, Kornbluth S
Title Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.
Journal Reference Authors Wu JQ, Kornbluth S
Title Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era.
Journal Reference Authors Schmidt A, Rauh NR, Nigg EA, Mayer TU
Title Cytostatic factor: an activity that puts the cell cycle on hold.
Journal Reference Authors Vogt E, Kirsch-Volders M, Parry J, Eichenlaub-Ritter U
Title Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error.
Journal Reference Authors Perry AC, Verlhac MH
Title Second meiotic arrest and exit in frogs and mice.
Journal Reference Authors Tunquist BJ, Eyers PA, Chen LG, Lewellyn AL, Maller JL
Title Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest.
Journal Reference Authors Hutchins JR, Dikovskaya D, Clarke PR.
Title Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
Journal Related gacu04914 Progesterone-mediated oocyte maturation
KO pathway LinkDB All DBs
