KEGG   PATHWAY: ggo00983
Entry
ggo00983                    Pathway                                
Name
Drug metabolism - other enzymes - Gorilla gorilla gorilla (western lowland gorilla)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
ggo00983  Drug metabolism - other enzymes
ggo00983

Organism
Gorilla gorilla gorilla (western lowland gorilla) [GN:ggo]
Gene
101131143  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
101132321  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X4 [KO:K00088] [EC:1.1.1.205]
101124914  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
109024945  inosine-5'-monophosphate dehydrogenase 1-like [KO:K00088] [EC:1.1.1.205]
101133381  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
101127379  TPMT; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
101138402  XDH; xanthine dehydrogenase/oxidase isoform X3 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
101149278  ITPA; inosine triphosphate pyrophosphatase isoform X2 [KO:K01519] [EC:3.6.1.66]
101149966  liver carboxylesterase 1 isoform X1 [KO:K01044] [EC:3.1.1.1]
115931015  liver carboxylesterase 1-like isoform X1 [KO:K01044] [EC:3.1.1.1]
115931059  CES1; liver carboxylesterase 1 isoform X1 [KO:K01044] [EC:3.1.1.1]
109023710  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
109023694  cocaine esterase [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
115931020  cocaine esterase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
101128458  cocaine esterase isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
101128088  cocaine esterase-like isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
101146584  UGT1A6; UDP-glucuronosyltransferase 1-6 isoform X3 [KO:K00699] [EC:2.4.1.17]
101135980  UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
101135156  UDP-glucuronosyltransferase 2B7 isoform X1 [KO:K00699] [EC:2.4.1.17]
101141374  UGT2B4; UDP-glucuronosyltransferase 2B4 [KO:K00699] [EC:2.4.1.17]
101140249  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
109026641  UDP-glucuronosyltransferase 2B10 isoform X1 [KO:K00699] [EC:2.4.1.17]
101139531  UDP-glucuronosyltransferase 2B10-like isoform X1 [KO:K00699] [EC:2.4.1.17]
101140616  UDP-glucuronosyltransferase 2B11-like isoform X1 [KO:K00699] [EC:2.4.1.17]
101133387  UGT2B15; UDP-glucuronosyltransferase 2B15 [KO:K00699] [EC:2.4.1.17]
101133016  UGT2B17; UDP-glucuronosyltransferase 2B17 [KO:K00699] [EC:2.4.1.17]
115934305  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
115934311  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B11-like [KO:K00699] [EC:2.4.1.17]
101146232  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A10 [KO:K00699] [EC:2.4.1.17]
101145885  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A8 [KO:K00699] [EC:2.4.1.17]
101141521  GUSB; beta-glucuronidase isoform X2 [KO:K01195] [EC:3.2.1.31]
101149513  cytochrome P450 3A4 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
101125125  CDA; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
101139229  DPYS; dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
101124006  UPB1; beta-ureidopropionase isoform X1 [KO:K01431] [EC:3.5.1.6]
101146638  cytochrome P450 2A6 [KO:K17683] [EC:1.14.14.-]
101134355  UPP1; uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
101125760  UPP2; uridine phosphorylase 2 isoform X1 [KO:K00757] [EC:2.4.2.3]
101148196  UCKL1; uridine-cytidine kinase-like 1 isoform X2 [KO:K00876] [EC:2.7.1.48]
101131511  UCK1; uridine-cytidine kinase 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
101128283  UCK2; uridine-cytidine kinase 2 isoform X1 [KO:K00876] [EC:2.7.1.48]
101132532  TK2; thymidine kinase 2, mitochondrial isoform X6 [KO:K00857] [EC:2.7.1.21]
101143822  TK1; thymidine kinase, cytosolic isoform X1 [KO:K00857] [EC:2.7.1.21]
101124432  UMPS; uridine 5'-monophosphate synthase isoform X1 [KO:K13421] [EC:2.4.2.10 4.1.1.23]
101147631  CMPK1; UMP-CMP kinase isoform X1 [KO:K13800] [EC:2.7.4.14]
101129602  RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
101133309  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
101128993  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
101149129  NME1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
101151650  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
101143314  NME6; nucleoside diphosphate kinase 6 isoform X3 [KO:K00940] [EC:2.7.4.6]
109025553  NME2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
101151858  NME7; nucleoside diphosphate kinase 7 isoform X3 [KO:K00940] [EC:2.7.4.6]
101152242  DUT; LOW QUALITY PROTEIN: deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
101135280  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
101150362  NAT1; arylamine N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
101152545  NAT2; arylamine N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
101151246  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
101153728  GSTA4; glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
101144905  MGST1; microsomal glutathione S-transferase 1 isoform X3 [KO:K00799] [EC:2.5.1.18]
101146886  LOW QUALITY PROTEIN: glutathione S-transferase theta-2 [KO:K00799] [EC:2.5.1.18]
101149517  glutathione S-transferase theta-1 isoform X2 [KO:K00799] [EC:2.5.1.18]
101148684  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
101127551  GSTM2; glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
101129341  GSTM1; glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
101128395  GSTM4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
101130552  GSTM5; glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
101128753  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
101123790  MGST3; glutathione S-transferase 3, mitochondrial isoform X1 [KO:K00799] [EC:2.5.1.18]
101151677  glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
101152035  glutathione S-transferase A3 isoform X1 [KO:K00799] [EC:2.5.1.18]
101153366  glutathione S-transferase A5 [KO:K00799] [EC:2.5.1.18]
101137199  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
101152643  LOW QUALITY PROTEIN: glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
101147042  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
101146214  GSTO1; glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
109024512  LOW QUALITY PROTEIN: glutathione S-transferase theta-2-like [KO:K00799] [EC:2.5.1.18]
101143444  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
109027180  glutathione S-transferase A1 isoform X1 [KO:K00799] [EC:2.5.1.18]
101148081  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
115934984  glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
101138588  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
101141693  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
101132221  glutathione S-transferase theta-4-like isoform X1 [KO:K00799] [EC:2.5.1.18]
101148812  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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