KEGG   PATHWAY: ggo04350
Entry
ggo04350                    Pathway                                
Name
TGF-beta signaling pathway - Gorilla gorilla gorilla (western lowland gorilla)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
ggo04350  TGF-beta signaling pathway
ggo04350

Other DBs
GO: 0007179
Organism
Gorilla gorilla gorilla (western lowland gorilla) [GN:ggo]
Gene
101125179  CHRD; chordin isoform X2 [KO:K04657]
101149968  NOG; noggin [KO:K04658]
101144616  NBL1; neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
109028020  GREM2; gremlin-2 isoform X2 [KO:K23318]
101135507  THBS1; thrombospondin-1 [KO:K16857]
101133609  DCN; decorin [KO:K04660]
101144896  FMOD; fibromodulin [KO:K08121]
101130441  left-right determination factor 1 [KO:K04668]
101131404  LEFTY2; left-right determination factor 2 isoform X1 [KO:K04668]
101124464  FST; follistatin isoform X3 [KO:K04661]
101149410  BMP2; bone morphogenetic protein 2 [KO:K21283]
101126138  BMP4; bone morphogenetic protein 4 isoform X2 [KO:K04662]
101152759  BMP6; bone morphogenetic protein 6 [KO:K16620]
101133226  INHBB; inhibin beta B chain [KO:K22687]
101125652  TF; serotransferrin isoform X1 [KO:K14736]
129532520  LOW QUALITY PROTEIN: inhibitor of carbonic anhydrase-like [KO:K14736]
101136011  BMP5; bone morphogenetic protein 5 [KO:K04663]
101142520  BMP7; bone morphogenetic protein 7 [KO:K16621]
101149312  bone morphogenetic protein 8A [KO:K16622]
115933734  BMP8B; bone morphogenetic protein 8B isoform X1 [KO:K16622]
101127151  GDF6; growth/differentiation factor 6 [KO:K20012]
101129236  GDF7; growth/differentiation factor 7 [KO:K20013]
101137456  AMH; muellerian-inhibiting factor [KO:K04665]
101151755  IFNG; interferon gamma [KO:K04687]
101131320  THSD4; thrombospondin type-1 domain-containing protein 4 isoform X2 [KO:K23377]
101152856  FBN1; fibrillin-1 isoform X1 [KO:K06825]
101124474  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
101125504  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
101133741  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101152285  INHBA; inhibin beta A chain [KO:K04667]
101138285  INHBC; inhibin beta C chain [KO:K22688]
101138658  INHBE; inhibin beta E chain [KO:K22689]
101141191  NODAL; nodal homolog isoform X1 [KO:K04666]
101135109  BMPR1A; bone morphogenetic protein receptor type-1A isoform X1 [KO:K04673] [EC:2.7.11.30]
101139693  bone morphogenetic protein receptor type-1A-like [KO:K04673] [EC:2.7.11.30]
101127602  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
101124161  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
101152104  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
101138065  NEO1; neogenin isoform X2 [KO:K06766]
101126285  HFE; hereditary hemochromatosis protein isoform X1 [KO:K26535]
101150922  TFRC; transferrin receptor protein 1 [KO:K06503]
101142491  RGMA; repulsive guidance molecule A [KO:K23096]
101143718  RGMB; repulsive guidance molecule B isoform X3 [KO:K06847]
101149682  AMHR2; anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
101128510  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
101146131  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
101142020  EMP3; epithelial membrane protein 3 [KO:K26257]
101132727  LRRC32; transforming growth factor beta activator LRRC32 isoform X1 [KO:K26316]
101124181  NRROS; transforming growth factor beta activator LRRC33 [KO:K26317]
101147783  ACVR1B; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
101153315  ACVR2B; activin receptor type-2B isoform X2 [KO:K13596] [EC:2.7.11.30]
101153902  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
101151586  IGSF1; immunoglobulin superfamily member 1 isoform X1 [KO:K26168]
101125374  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
101128924  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
101137217  SMAD5; mothers against decapentaplegic homolog 5 [KO:K16790]
101138667  SMAD9; mothers against decapentaplegic homolog 9 isoform X1 [KO:K16791]
101154310  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
109025264  SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605]
101153595  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
101133854  SMAD6; mothers against decapentaplegic homolog 6 [KO:K04677]
101143469  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
101136832  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X2 [KO:K04678] [EC:2.3.2.26]
101135070  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
101135816  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
101134105  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
101151577  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
109025459  CUL1; cullin-1 [KO:K03347]
101140164  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101135988  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101134778  RHOA; transforming protein RhoA [KO:K04513]
101154194  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101142397  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101145146  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
101125226  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101152519  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101134525  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
101126746  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101142391  HAMP; hepcidin [KO:K23106]
101141294  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
101142351  LOW QUALITY PROTEIN: DNA-binding protein inhibitor ID-2 [KO:K17693]
101149541  ID3; DNA-binding protein inhibitor ID-3 [KO:K17694]
115934998  ID4; DNA-binding protein inhibitor ID-4 isoform X1 [KO:K17695]
101152899  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
101146622  E2F4; transcription factor E2F4 [KO:K04682]
101127769  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
101141844  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
101140666  transcription factor Dp-1-like [KO:K04683]
101144808  CREBBP; CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]
101153383  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
101124807  SKIL; ski-like protein [KO:K18499]
101150925  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
101151959  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
109023024  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
101148051  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
101129540  TGIF1; homeobox protein TGIF1 isoform X1 [KO:K19383]
101138486  TGIF2; homeobox protein TGIF2 [KO:K19553]
101137026  MYC; myc proto-oncogene protein [KO:K04377]
101146090  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
101152607  PITX2; pituitary homeobox 2 isoform X1 [KO:K04686]
101132974  HJV; hemojuvelin [KO:K23100]
101136957  GREM1; gremlin-1 [KO:K23318]
101144521  LTBP1; latent-transforming growth factor beta-binding protein 1 isoform X5 [KO:K19559]
101150703  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
ggo04010  MAPK signaling pathway
ggo04110  Cell cycle
ggo04120  Ubiquitin mediated proteolysis
ggo04210  Apoptosis
KO pathway
ko04350   
LinkDB

DBGET integrated database retrieval system