KEGG   PATHWAY: hoc04814
Entry
hoc04814                    Pathway                                
Name
Motor proteins - Hemiscyllium ocellatum (epaulette shark)
Class
Cellular Processes; Cell motility
Pathway map
hoc04814  Motor proteins
hoc04814

Organism
Hemiscyllium ocellatum (epaulette shark) [GN:hoc]
Gene
132818343  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
132816449  dync2h1; dynein cytoplasmic 2 heavy chain 1 [KO:K10414]
132805683  cytoplasmic dynein 1 intermediate chain 2-like [KO:K10415]
132816034  cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
132817113  cytoplasmic dynein 1 intermediate chain 2-like [KO:K10415]
132823859  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
132815759  cytoplasmic dynein 1 light intermediate chain 1-like [KO:K10416]
132819379  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
132830438  dynein light chain 2, cytoplasmic [KO:K10418]
132827384  dynein light chain 2, cytoplasmic-like [KO:K10418]
132822803  dynein light chain roadblock-type 2-like [KO:K10419]
132823870  dynein light chain roadblock-type 2 [KO:K10419]
132829955  dynein light chain Tctex-type 1 [KO:K10420]
132819460  dynein light chain Tctex-type 1-like isoform X1 [KO:K10420]
132820755  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
132818529  dynein light chain Tctex-type 5 [KO:K25420]
132818727  dynlt5; dynein light chain Tctex-type 5 [KO:K25421]
132817611  dnah9l; dynein axonemal heavy chain 11 [KO:K10408]
132817623  dnah7; dynein axonemal heavy chain 7 [KO:K10408]
132822036  dnah1; dynein axonemal heavy chain 1 [KO:K10408]
132826812  dynein axonemal heavy chain 3-like isoform X1 [KO:K10408]
132834399  dynein axonemal heavy chain 8-like [KO:K10408]
132832876  dynein axonemal heavy chain 6-like [KO:K10408]
132834281  dynein axonemal heavy chain 8-like [KO:K10408]
132835340  dnah2; dynein axonemal heavy chain 2 [KO:K10408]
132822476  dnah12; dynein axonemal heavy chain 12 [KO:K10408]
132824077  LOW QUALITY PROTEIN: dynein axonemal heavy chain 5-like [KO:K10408]
132815922  dnah5; dynein axonemal heavy chain 5 [KO:K10408]
132827436  dnah10; dynein axonemal heavy chain 10 [KO:K10408]
132816011  dynein axonemal heavy chain 11-like isoform X1 [KO:K10408]
132816088  dnah5l; dynein axonemal heavy chain 5 [KO:K10408]
132825561  dnah3; dynein axonemal heavy chain 3 [KO:K10408]
132827851  dynein axonemal heavy chain 9-like isoform X1 [KO:K10408]
132827952  dynein axonemal heavy chain 17-like [KO:K10408]
132826001  dnah6; dynein axonemal heavy chain 6 [KO:K10408]
132820280  dnai1.2; dynein, axonemal, intermediate chain 1, paralog 2 [KO:K10409]
132827968  dnai2b; dynein axonemal intermediate chain 2 [KO:K11143]
132818566  dnai3; dynein axonemal intermediate chain 3 [KO:K24722]
132818513  dnai4; dynein axonemal intermediate chain 4 [KO:K24723]
132830031  dnali1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
132835492  axonemal dynein light intermediate polypeptide 1-like [KO:K10410]
132817793  dnal1; dynein axonemal light chain 1 [KO:K10411]
132831375  dynein axonemal light chain 4-like [KO:K10412]
132819861  dynactin subunit 1-like isoform X1 [KO:K04648]
132812046  dctn2; dynactin subunit 2 [KO:K10424]
132835733  dctn3; dynactin subunit 3 [KO:K10425]
132823496  dctn4; dynactin subunit 4 [KO:K10426]
132825455  dctn5; dynactin subunit 5 [KO:K10427]
132833367  dctn6; dynactin subunit 6 isoform X1 [KO:K10428]
132837045  beta-centractin [KO:K16575]
132826373  alpha-centractin [KO:K16575]
132817892  actr10; actin-related protein 10 isoform X1 [KO:K16576]
132822491  F-actin-capping protein subunit alpha-2-like [KO:K10364]
132824921  F-actin-capping protein subunit alpha-2 [KO:K10364]
132828307  capza1b; F-actin-capping protein subunit alpha-1b [KO:K10364]
132833822  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
132830423  BICD family-like cargo adapter 1 [KO:K16756]
132827182  bicdl1; BICD family-like cargo adapter 1 [KO:K16756]
132833439  protein Hook homolog 3 isoform X1 [KO:K16536]
132817713  tubulin alpha-1B chain-like [KO:K07374]
132817714  tubulin alpha-1D chain [KO:K07374]
132817715  tubulin alpha-4A chain-like [KO:K07374]
132817716  tubulin alpha-4A chain-like isoform X1 [KO:K07374]
132817717  tubulin alpha chain-like isoform X1 [KO:K07374]
132805759  tubulin alpha-1C chain [KO:K07374]
132805859  tubulin alpha-1A chain [KO:K07374]
132805860  tubulin alpha chain [KO:K07374]
132805865  tubulin alpha chain [KO:K07374]
132809083  tubulin alpha chain-like [KO:K07374]
132809088  tubulin alpha-1B chain-like [KO:K07374]
132809093  tubulin alpha-3 chain-like [KO:K07374]
132809094  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
132809099  tubulin alpha chain-like isoform X1 [KO:K07374]
132809103  tubulin alpha-1B chain-like isoform X1 [KO:K07374]
132809104  tubulin alpha chain-like [KO:K07374]
132813390  tubulin alpha-4A chain-like [KO:K07374]
132813468  tubulin alpha-1D chain-like [KO:K07374]
132828477  tubulin alpha chain-like isoform X1 [KO:K07374]
132832193  tubb6; tubulin, beta 6 class V isoform X1 [KO:K07375]
132832532  tubulin beta-4B chain [KO:K07375]
132822865  tubulin beta-4 chain-like [KO:K07375]
132822883  tubulin beta chain-like [KO:K07375]
132823686  tubulin beta-3 chain [KO:K07375]
132813516  tubulin beta chain [KO:K07375]
132815101  tubulin beta-5 chain-like [KO:K07375]
132825782  tubulin beta-4B chain-like isoform X1 [KO:K07375]
132825784  tubulin beta chain-like [KO:K07375]
132825793  tubulin beta chain-like [KO:K07375]
132825794  tubulin beta chain-like [KO:K07375]
132830704  tubg1; tubulin gamma-1 chain [KO:K10389]
132822838  tubd1; tubulin delta chain isoform X1 [KO:K10390]
132805825  tube1; tubulin epsilon chain [KO:K10391]
132812583  kinesin heavy chain-like [KO:K10396]
132815810  kinesin-1 heavy chain [KO:K10396]
132817400  kinesin heavy chain [KO:K10396]
132830310  klc1b; kinesin light chain 1b isoform X1 [KO:K10407]
132836560  klc3; kinesin light chain 3 isoform X1 [KO:K10407]
132818323  klc1a; kinesin light chain 1 isoform X1 [KO:K10407]
132823465  kif3a; kinesin-like protein KIF3A [KO:K10394]
132822960  kif3b; kinesin-like protein KIF3B [KO:K20196]
132818715  kifap3a; kinesin-associated protein 3a isoform X1 [KO:K25388]
132808220  kinesin-like protein KIF3C isoform X1 [KO:K20197]
132833551  kif17; kinesin-like protein KIF17 [KO:K20198]
132833809  kif1b; kinesin-like protein KIF1B isoform X1 [KO:K10392]
132821620  kif1aa; kinesin-like protein KIF1A isoform X1 [KO:K10392]
132832106  kif13a; kinesin-like protein KIF13A isoform X1 [KO:K17914]
132819649  kinesin-like protein KIF13B isoform X1 [KO:K17914]
132818991  kif14; kinesin-like protein KIF14 isoform X1 [KO:K17915]
132819896  kif16ba; kinesin-like protein KIF16B isoform X1 [KO:K17916]
132820528  kif4; kinesin family member 4 isoform X1 [KO:K10395]
132834153  kif7; kinesin-like protein kif7 isoform X1 [KO:K18806]
132828390  kif21b; kinesin-like protein KIF21B isoform X1 [KO:K24185]
132826764  kif21a; kinesin-like protein KIF21A isoform X1 [KO:K24185]
132825920  kinesin-like protein KIF27 [KO:K24186]
132826451  kif11; kinesin-like protein KIF11 [KO:K10398]
132823321  kif20a; kinesin-like protein KIF20A isoform X1 [KO:K10402]
132826223  kinesin-like protein KIF20B isoform X1 [KO:K10402]
132834299  kif23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
132826243  cenpe; centromere-associated protein E [KO:K11498]
132831386  kinesin-like protein KIF18A [KO:K10401]
132824504  kif18a; kinesin-like protein KIF18A isoform X1 [KO:K10401]
132825298  kinesin-like protein KIF19 [KO:K26157]
132827969  kif19; kinesin-like protein KIF19 [KO:K26157]
132835167  kif6; kinesin-like protein KIF6 [KO:K10397]
132815232  kif9; kinesin-like protein KIF9 [KO:K10397]
132813908  kinesin-like protein KIF22 isoform X1 [KO:K10403]
132813909  LOW QUALITY PROTEIN: kinesin-like protein KIF22 [KO:K10403]
132818321  kif26ab; kinesin-like protein KIF26A isoform X1 [KO:K10404]
132819662  kif26ba; kinesin-like protein KIF26B [KO:K10404]
132832259  kif15; kinesin-like protein KIF15 isoform X1 [KO:K10400]
132818791  kif2c; kinesin-like protein KIF2C isoform X1 [KO:K10393]
132823298  kinesin-like protein KIF24 [KO:K10393]
132819029  kif2a; kinesin-like protein KIF2A isoform X1 [KO:K10393]
132832409  kifc1; kinesin-like protein KIFC1 [KO:K10405]
132824009  kifc3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
132816252  kinesin-like protein KIFC3 [KO:K10406]
132825898  uncharacterized protein LOC132825898 [KO:K10406]
132805690  unconventional myosin-Ib-like [KO:K10356]
132830518  unconventional myosin-Ic-like isoform X1 [KO:K10356]
132831026  myo1d; unconventional myosin-Id [KO:K10356]
132834138  myo1ea; unconventional myosin-Ie isoform X1 [KO:K10356]
132815482  unconventional myosin-Id-like [KO:K10356]
132827295  myo1ha; unconventional myosin-Ih [KO:K10356]
132828815  myo1f; unconventional myosin-If [KO:K10356]
132817163  myo1b; unconventional myosin-Ib isoform X1 [KO:K10356]
132817464  myo3b; myosin-IIIb [KO:K08834] [EC:2.7.11.1]
132816219  myo3a; myosin-IIIa [KO:K08834] [EC:2.7.11.1]
132832210  myo5b; unconventional myosin-Vb isoform X1 [KO:K10357]
132834339  unconventional myosin-Va-like [KO:K10357]
132834367  unconventional myosin-Vc-like isoform X1 [KO:K10357]
132829215  unconventional myosin-Va-like [KO:K10357]
132819818  unconventional myosin-VI-like isoform X1 [KO:K10358]
132816552  myo7aa; myosin VIIAa [KO:K10359]
132821379  unconventional myosin-VIIa-like [KO:K21868]
132834852  myo9aa; unconventional myosin-IXAa isoform X1 [KO:K10360]
132829070  unconventional myosin-IXb-like isoform X1 [KO:K10360]
132817680  unconventional myosin-X-like [KO:K12559]
132815620  myo10; unconventional myosin-X [KO:K12559]
132825597  myo15aa; unconventional myosin-XV [KO:K10361]
132816636  myo16; unconventional myosin-XVI [KO:K17481]
132827048  unconventional myosin-XVIIIb-like isoform X1 [KO:K10362]
132830549  myo18ab; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
132830460  unconventional myosin-XIX [KO:K25838]
132823041  myosin-7-like [KO:K24220]
132815876  myosin-7B-like [KO:K24220]
132827661  myosin-1B [KO:K24220]
132827662  myosin-4-like [KO:K24220]
132827664  myosin-4-like [KO:K24220]
132827666  myosin-4-like [KO:K24220]
132827990  myosin-2-like [KO:K24220]
132831254  myosin-9-like isoform X1 [KO:K10352]
132827645  myosin-10 isoform X1 [KO:K10352]
132825314  myosin-11-like isoform X1 [KO:K10352]
132817288  myosin light chain 1, skeletal muscle isoform-like isoform X1 [KO:K05738]
132815047  myosin light chain 3-like [KO:K12749]
132831022  myl4; myosin light chain 4 [KO:K12750]
132805777  myosin light polypeptide 6-like isoform X1 [KO:K12751]
132827118  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
132833455  myosin light chain 5-like [KO:K12753]
132837052  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
132822971  myosin regulatory light polypeptide 9 [KO:K12755]
132830564  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K12756]
132814948  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
132826217  acta2; actin, aortic smooth muscle [KO:K12313]
132836344  actin, alpha cardiac muscle 1-like [KO:K12314]
132818173  actin, alpha cardiac muscle 1 [KO:K12314]
132815054  actin, cytoplasmic type 5-like isoform X1 [KO:K05692]
132815056  actin, cytoplasmic type 5-like isoform X1 [KO:K05692]
132815057  actin-3-like [KO:K05692]
132815131  actin, non-muscle 6.2-like [KO:K05692]
132815132  actin, non-muscle 6.2 [KO:K05692]
132815133  actin, non-muscle 6.2-like [KO:K05692]
132825506  actb2; actin, cytoplasmic 2 [KO:K05692]
132828025  actin, cytoplasmic type 5 [KO:K05692]
132828784  uncharacterized protein LOC132828784 [KO:K10355]
132821745  actin-like isoform X1 [KO:K10355]
132822102  troponin C, slow skeletal and cardiac muscles [KO:K05865]
132828407  troponin I, slow skeletal muscle-like isoform X1 [KO:K10371]
132826619  troponin I, slow skeletal muscle-like [KO:K10371]
132826620  troponin I, slow skeletal muscle-like [KO:K10371]
132831195  troponin T, slow skeletal muscle-like [KO:K10372]
132822703  troponin C, skeletal muscle-like [KO:K12042]
132822891  troponin C, skeletal muscle-like isoform X1 [KO:K12042]
132824416  troponin I, fast skeletal muscle-like [KO:K12043]
132824413  troponin T, fast skeletal muscle isoforms-like isoform X1 [KO:K12046]
132826621  troponin T, fast skeletal muscle isoforms-like [KO:K12046]
132828116  tnnt2a; troponin T type 2a (cardiac) [KO:K12045]
132834645  tropomyosin alpha-1 chain isoform X1 [KO:K10373]
132806133  tropomyosin alpha-1 chain-like isoform X1 [KO:K10373]
132805620  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
132829072  tropomyosin alpha-1 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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