KEGG   PATHWAY: hvi03013
Entry
hvi03013                    Pathway                                
Name
Nucleocytoplasmic transport - Homalodisca vitripennis (glassy-winged sharpshooter)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
hvi03013  Nucleocytoplasmic transport
hvi03013

Other DBs
GO: 0050658
Organism
Homalodisca vitripennis (glassy-winged sharpshooter) [GN:hvi]
Gene
124362150  aladin-like [KO:K14320]
124362140  nucleoporin NUP42-like [KO:K14321]
124368962  DEAD-box helicase Dbp80-like [KO:K18655] [EC:5.6.2.7]
124360183  DEAD-box helicase Dbp80-like isoform X1 [KO:K18655] [EC:5.6.2.7]
124368152  protein Rae1 [KO:K14298]
124365155  ran GTPase-activating protein 1 [KO:K14319]
124374230  SUMO-conjugating enzyme UBC9-B [KO:K10577]
124368797  small ubiquitin-related modifier 3 [KO:K12160]
124364201  nuclear pore complex protein Nup160 homolog isoform X1 [KO:K14303]
124372320  LOW QUALITY PROTEIN: nuclear pore complex protein Nup85-like [KO:K14304]
124362738  nuclear pore complex protein Nup85-like [KO:K14304]
124353226  protein SEC13 homolog [KO:K14004]
124370620  nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
124360130  nuclear pore complex protein Nup133 [KO:K14300]
124364970  nucleoporin SEH1 [KO:K14299]
124352813  nucleoporin Nup43 [KO:K14305]
124362498  nucleoporin Nup37 [KO:K14302]
124355356  LOW QUALITY PROTEIN: nuclear pore glycoprotein p62-like [KO:K14306]
124357787  nucleoporin p58/p45-like [KO:K14307]
124360139  nuclear pore complex protein Nup54 [KO:K14308]
124370442  nuclear pore complex protein Nup205-like [KO:K14310]
124352769  LOW QUALITY PROTEIN: nuclear pore complex protein Nup205-like [KO:K14310]
124352703  nuclear pore complex protein Nup155 [KO:K14312]
124364570  nuclear pore complex protein Nup93-like [KO:K14309]
124359724  nucleoporin NUP35 isoform X1 [KO:K14313]
124363285  nucleoporin NDC1 [KO:K14315]
124355077  LOW QUALITY PROTEIN: nuclear pore membrane glycoprotein 210-like [KO:K14314]
124357540  Krueppel homolog 2 isoform X1 [KO:K20724]
124362604  LOW QUALITY PROTEIN: nucleoprotein TPR-like [KO:K09291]
124362507  nuclear pore complex protein Nup50 [KO:K14295]
124358749  nuclear pore complex protein Nup153-like isoform X1 [KO:K14296]
124359376  importin subunit alpha-1 [KO:K15043]
124364884  importin subunit alpha-3 [KO:K23583]
124358989  importin subunit alpha-7 [KO:K15042]
124364802  LOW QUALITY PROTEIN: importin subunit beta-1 [KO:K14293]
124355043  transportin-1 [KO:K18752]
124357281  transportin-3 [KO:K15436]
124359941  importin-5 isoform X1 [KO:K20222]
124374839  LOW QUALITY PROTEIN: importin-7-like [KO:K20223]
124365898  importin-11-like [KO:K25201]
124366732  importin-11-like [KO:K25201]
124366771  importin-13 [KO:K25202]
124354630  snurportin-1 [KO:K13151]
124356901  exportin-1 [KO:K14290]
124357979  exportin-2 [KO:K18423]
124361289  LOW QUALITY PROTEIN: exportin-4-like [KO:K25203]
124362247  exportin-5 [KO:K14289]
124367772  exportin-6-A isoform X1 [KO:K25204]
124353147  exportin-7 isoform X1 [KO:K18460]
124367857  GTP-binding nuclear protein Ran [KO:K07936]
124359623  LOW QUALITY PROTEIN: elongation factor 1-alpha-like [KO:K03231]
124355317  phosphorylated adapter RNA export protein-like isoform X1 [KO:K14291]
124355975  phosphorylated adapter RNA export protein-like [KO:K14291]
124366034  nuclear cap-binding protein subunit 1 [KO:K12882]
124359604  nuclear cap-binding protein subunit 2 [KO:K12883]
124363956  nuclear cap-binding protein subunit 2-like [KO:K12883]
124362393  60S ribosomal export protein NMD3 [KO:K07562]
124354781  RNA-binding protein 8A [KO:K12876]
124367460  protein mago nashi homolog [KO:K12877]
124352659  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
124364287  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
124353732  histone deacetylase complex subunit SAP18 [KO:K14324]
124352818  pinin isoform X1 [KO:K13114]
124367989  THO complex subunit 4-like [KO:K12881]
124370099  THO complex subunit 4-like [KO:K12881]
124370585  THO complex subunit 4-like [KO:K12881]
124370586  THO complex subunit 4-like [KO:K12881]
124370635  THO complex subunit 4-like [KO:K12881]
124370790  THO complex subunit 4-like [KO:K12881]
124370816  aly/REF export factor 2-like [KO:K12881]
124370817  THO complex subunit 4-like [KO:K12881]
124371449  THO complex subunit 4-like [KO:K12881]
124371451  THO complex subunit 4-like [KO:K12881]
124371452  THO complex subunit 4-like [KO:K12881]
124371453  THO complex subunit 4-like [KO:K12881]
124372931  THO complex subunit 4-A-like [KO:K12881]
124373895  THO complex subunit 4-like [KO:K12881]
124373896  THO complex subunit 4-like [KO:K12881]
124373897  THO complex subunit 4-like [KO:K12881]
124373898  THO complex subunit 4-like [KO:K12881]
124373899  THO complex subunit 4-like [KO:K12881]
124373900  THO complex subunit 4-like [KO:K12881]
124373901  THO complex subunit 4-like [KO:K12881]
124373902  THO complex subunit 4-like [KO:K12881]
124373903  THO complex subunit 4-like [KO:K12881]
124374092  THO complex subunit 4-like [KO:K12881]
124374253  THO complex subunit 4-like [KO:K12881]
124374878  THO complex subunit 4-like [KO:K12881]
124365742  LOW QUALITY PROTEIN: regulator of nonsense transcripts 1 homolog [KO:K14326] [EC:5.6.2.5 5.6.2.3]
124358360  regulator of nonsense transcripts 2-like [KO:K14327]
124369048  regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
124356701  nuclear RNA export factor 1-like [KO:K14284]
124363458  NTF2-related export protein [KO:K14285]
124365861  partner of Y14 and mago [KO:K14294]
124353596  THO complex subunit 1 [KO:K12878]
124357980  THO complex subunit 2 isoform X1 [KO:K12879]
124360534  THO complex subunit 7 homolog isoform X1 [KO:K13176]
124355040  LOW QUALITY PROTEIN: THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
hvi03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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