KEGG   PATHWAY: lak00260
Entry
lak00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Lingula anatina
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
lak00260  Glycine, serine and threonine metabolism
lak00260

Module
lak_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:lak00260]
lak_M00047  Creatine pathway [PATH:lak00260]
lak_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:lak00260]
lak_M00555  Betaine biosynthesis, choline => betaine [PATH:lak00260]
lak_M00621  Glycine cleavage system [PATH:lak00260]
lak_M00974  Betaine metabolism, animals, betaine => glycine [PATH:lak00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Lingula anatina [GN:lak]
Gene
106151317  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
106152198  serine hydroxymethyltransferase, cytosolic-like [KO:K00600] [EC:2.1.2.1]
106155097  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
106178363  serine--pyruvate aminotransferase isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
106162811  serine--pyruvate aminotransferase isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
106172632  glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
106162927  glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
106151329  glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
106155287  uncharacterized protein LOC106155287 [KO:K01834] [EC:5.4.2.11]
106168268  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
106172803  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
106155397  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
106152633  phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
106161087  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial-like [KO:K00639] [EC:2.3.1.29]
106181250  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
106153279  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
106164039  5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
106151999  probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
106158573  amine oxidase [flavin-containing]-like isoform X1 [KO:K00274] [EC:1.4.3.4]
106160014  amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
106161269  probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
106161270  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
106177557  amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
106152866  amiloride-sensitive amine oxidase [copper-containing] isoform X1 [KO:K00276] [EC:1.4.3.21]
106168499  glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]
106164590  LOW QUALITY PROTEIN: glycine dehydrogenase (decarboxylating), mitochondrial-like [KO:K00281] [EC:1.4.4.2]
106166562  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
106181444  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
106179947  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
106152400  uncharacterized protein LOC106152400 [KO:K02437]
106159439  uncharacterized protein LOC106159439 [KO:K02437]
106171871  D-aspartate oxidase [KO:K00273] [EC:1.4.3.3]
106171870  D-aspartate oxidase-like [KO:K00273] [EC:1.4.3.3]
106163654  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
106169635  glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
106178783  guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
106178838  uncharacterized protein LOC106178838 isoform X1 [KO:K00108] [EC:1.1.99.1]
106172052  alpha-aminoadipic semialdehyde dehydrogenase-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
106170433  alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
106166449  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
106171079  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
106171080  betaine--homocysteine S-methyltransferase 1 isoform X1 [KO:K00544] [EC:2.1.1.5]
106171100  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
106167822  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
106178981  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
106179201  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
106156503  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
106166038  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
106166448  dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
106181817  peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
106181819  peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
106181831  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
106167453  sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
106167602  glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]
106161612  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
106172713  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
106175947  uncharacterized protein LOC106175947 [KO:K01754] [EC:4.3.1.19]
106154628  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
106154630  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
106173276  uncharacterized protein LOC106173276 [KO:K20498] [EC:4.3.1.18]
106154076  probable serine racemase [KO:K12235] [EC:5.1.1.18]
106154077  probable serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
lak00010  Glycolysis / Gluconeogenesis
lak00020  Citrate cycle (TCA cycle)
lak00230  Purine metabolism
lak00250  Alanine, aspartate and glutamate metabolism
lak00270  Cysteine and methionine metabolism
lak00290  Valine, leucine and isoleucine biosynthesis
lak00300  Lysine biosynthesis
lak00330  Arginine and proline metabolism
lak00470  D-Amino acid metabolism
lak00564  Glycerophospholipid metabolism
lak00600  Sphingolipid metabolism
lak00620  Pyruvate metabolism
lak00630  Glyoxylate and dicarboxylate metabolism
lak00640  Propanoate metabolism
lak00860  Porphyrin metabolism
lak00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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