KEGG PATHWAY: ldi00260

PATHWAY: ldi00260

Entry

ldi00260                    Pathway

Name

Glycine, serine and threonine metabolism - Leptosomus discolor (cuckoo roller)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

ldi00260

Glycine, serine and threonine metabolism

Module

ldi_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:ldi00260]

ldi_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ldi00260]

ldi_M00555

Betaine biosynthesis, choline => betaine [PATH:ldi00260]

ldi_M00621

Glycine cleavage system [PATH:ldi00260]

ldi_M00974

Betaine metabolism, animals, betaine => glycine [PATH:ldi00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Leptosomus discolor (cuckoo roller) [GN:ldi]

Gene

104340233

SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]

104354233

SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]

104351391

AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

104346965

GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

104343403

GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]

104347839

PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

104341706

BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

104349924

PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

104342593

PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

104351414

PSPH; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]

104346848

GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

104351689

L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]

104340482

ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]

104343669

MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]

104354788

LOW QUALITY PROTEIN: amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]

104352708

membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]

104351512

glycine dehydrogenase (decarboxylating), mitochondrial-like [KO:K00281] [EC:1.4.4.2]

104346836

AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

104350220

DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

104352562

GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]

104343878

DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]

104339983

AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]

104348433

GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

104342481

CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

104350723

ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

104348421

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

104342607

DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]

104347186

PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

104353408

SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

104349264

GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

104351141

CBS; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]

104351143

cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]

104345546

CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

104348853

probable serine racemase [KO:K01754] [EC:4.3.1.19]

104354466

SRR; serine racemase [KO:K12235] [EC:5.1.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721