Entry Name VEGF signaling pathway - Megalobrama amblycephala (Wuchang bream)
Description There is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic angiogenesis. The binding of VEGF to VEGFR-2 leads to a cascade of different signaling pathways, resulting in the up-regulation of genes involved in mediating the proliferation and migration of endothelial cells and promoting their survival and vascular permeability. For example, the binding of VEGF to VEGFR-2 leads to dimerization of the receptor, followed by intracellular activation of the PLCgamma;PKC-Raf kinase-MEK-mitogen-activated protein kinase (MAPK) pathway and subsequent initiation of DNA synthesis and cell growth, whereas activation of the phosphatidylinositol 3' -kinase (PI3K)-Akt pathway leads to increased endothelial-cell survival. Activation of PI3K, FAK, and p38 MAPK is implicated in cell migration signaling.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Megalobrama amblycephala (Wuchang bream) [GN:
mamb ]
Gene 125243192 vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448 ]
125244347 vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448 ]
125275480 si:ch73-109i22.2; SH2 domain-containing protein 2A isoform X1 [KO:K08273 ]
125260147 plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
125253968 plcg2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
125253954 map2k1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368 ] [EC:2.7.12.2 ]
125259186 ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
125252654 ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
125265608 serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
125259721 nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
125256283 cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
125267091 hspb15; heat shock protein, alpha-crystallin-related, b15 [KO:K04455 ]
125248809 pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
125256148 pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
125259868 zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
125259888 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
125273996 pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649 ]
125267879 pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
125250735 pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
125250270 pik3r3a; phosphoinositide-3-kinase, regulatory subunit 3a (gamma) [KO:K02649 ]
125260328 ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392 ]
125264027 LOW QUALITY PROTEIN: bcl2-associated agonist of cell death-like [KO:K02158 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L.
Title VEGF-receptor signal transduction.
Journal Reference Authors Matsumoto T, Claesson-Welsh L.
Title VEGF receptor signal transduction.
Journal Reference Authors Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA.
Title Vascular endothelial growth factor and angiogenesis.
Journal Reference Authors Takahashi H, Shibuya M.
Title The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions.
Journal Reference Authors Zachary I.
Title VEGF signalling: integration and multi-tasking in endothelial cell biology.
Journal Reference Authors Munoz-Chapuli R, Quesada AR, Angel Medina M.
Title Angiogenesis and signal transduction in endothelial cells.
Journal Reference Authors Lamalice L, Houle F, Jourdan G, Huot J.
Title Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38.
Journal Reference Authors Shu X, Wu W, Mosteller RD, Broek D.
Title Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases.
Journal Related KO pathway LinkDB All DBs
