KEGG   PATHWAY: masi00270
Entry
masi00270                   Pathway                                
Name
Cysteine and methionine metabolism - Myxocyprinus asiaticus (Chinese sucker)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
masi00270  Cysteine and methionine metabolism
masi00270

Module
masi_M00034  Methionine salvage pathway [PATH:masi00270]
masi_M00035  Methionine degradation [PATH:masi00270]
masi_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:masi00270]
Other DBs
GO: 0006534 0006555
Organism
Myxocyprinus asiaticus (Chinese sucker) [GN:masi]
Gene
127446550  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
127448718  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
127449633  kynurenine--oxoglutarate transaminase 3 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
127427769  kynurenine--oxoglutarate transaminase 1 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
127443698  cystathionine beta-synthase a isoform X1 [KO:K01697] [EC:4.2.1.22]
127447077  cystathionine beta-synthase-like protein [KO:K01697] [EC:4.2.1.22]
127448191  cystathionine beta-synthase-like protein [KO:K01697] [EC:4.2.1.22]
127430858  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
127446364  homocysteine S-methyltransferase YbgG-like isoform X1 [KO:K00547] [EC:2.1.1.10]
127448768  uncharacterized protein LOC127448768 [KO:K00547] [EC:2.1.1.10]
127423503  methionine synthase isoform X1 [KO:K00548] [EC:2.1.1.13]
127412481  S-adenosylmethionine synthase isoform X1 [KO:K00789] [EC:2.5.1.6]
127437290  S-adenosylmethionine synthase-like isoform X1 [KO:K00789] [EC:2.5.1.6]
127413656  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
127426759  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
127432762  methionine adenosyltransferase II, alpha a [KO:K00789] [EC:2.5.1.6]
127433552  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
127434008  methionine adenosyltransferase II, alpha-like isoform X1 [KO:K00789] [EC:2.5.1.6]
127429041  methionine adenosyltransferase 2 subunit beta isoform X1 [KO:K00789] [EC:2.5.1.6]
127409914  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
127416163  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
127419176  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
127420141  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
127431325  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
127428474  spermine synthase [KO:K00802] [EC:2.5.1.22]
127445192  S-methyl-5'-thioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]
127447044  purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
127448559  purine nucleoside phosphorylase LACC1-like isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
127444212  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
127444999  methylthioribose-1-phosphate isomerase-like [KO:K08963] [EC:5.3.1.23]
127432644  methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
127432657  enolase-phosphatase E1 isoform X1 [KO:K09880] [EC:3.1.3.77]
127434054  enolase-phosphatase E1-like isoform X1 [KO:K09880] [EC:3.1.3.77]
127455403  acireductone dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
127455909  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
127417269  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
127421781  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
127429679  L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
127410990  glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
127449946  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
127452089  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
127409611  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
127415640  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
127411308  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
127455032  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
127424414  uncharacterized protein LOC127424414 isoform X1 [KO:K17399] [EC:2.1.1.37]
127419381  LOW QUALITY PROTEIN: uncharacterized protein LOC127419381 [KO:K17399] [EC:2.1.1.37]
127419398  DNA (cytosine-5)-methyltransferase 3B-like [KO:K17399] [EC:2.1.1.37]
127420365  DNA (cytosine-5)-methyltransferase 3B-like [KO:K17399] [EC:2.1.1.37]
127420369  DNA (cytosine-5)-methyltransferase 3B-like isoform X1 [KO:K17399] [EC:2.1.1.37]
127415429  DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a isoform X1 [KO:K17399] [EC:2.1.1.37]
127436481  adenosylhomocysteinase like 2b [KO:K01251] [EC:3.13.2.1]
127437762  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
127445952  adenosylhomocysteinase A [KO:K01251] [EC:3.13.2.1]
127414959  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
127435028  putative adenosylhomocysteinase 3 [KO:K01251] [EC:3.13.2.1]
127448899  adenosylhomocysteinase B [KO:K01251] [EC:3.13.2.1]
127424217  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
127436173  adenosylhomocysteinase like 2a isoform X1 [KO:K01251] [EC:3.13.2.1]
127436940  branched-chain-amino-acid aminotransferase, cytosolic isoform X1 [KO:K00826] [EC:2.6.1.42]
127451910  branched-chain-amino-acid aminotransferase, mitochondrial [KO:K00826] [EC:2.6.1.42]
127435468  branched-chain-amino-acid aminotransferase, cytosolic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
127430776  alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
127428452  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
127413615  glutamate--cysteine ligase catalytic subunit isoform X1 [KO:K11204] [EC:6.3.2.2]
127411739  glutamate--cysteine ligase catalytic subunit-like isoform X1 [KO:K11204] [EC:6.3.2.2]
127415206  glutamate--cysteine ligase regulatory subunit [KO:K11205]
127423703  glutamate--cysteine ligase regulatory subunit-like isoform X1 [KO:K11205]
127419239  glutathione synthetase-like isoform X1 [KO:K21456] [EC:6.3.2.3]
127419956  glutathione synthetase-like isoform X1 [KO:K21456] [EC:6.3.2.3]
127414587  cysteine dioxygenase type 1 [KO:K00456] [EC:1.13.11.20]
127423892  cysteine dioxygenase type 1-like [KO:K00456] [EC:1.13.11.20]
127424310  putative aspartate aminotransferase, cytoplasmic 2 [KO:K14454] [EC:2.6.1.1]
127412252  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
127413726  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
127449545  glutamic-oxaloacetic transaminase 2b, mitochondrial [KO:K14455] [EC:2.6.1.1]
127455978  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
127446492  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
127417169  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
127452331  3-mercaptopyruvate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]
127436853  L-lactate dehydrogenase B-A chain isoform X1 [KO:K00016] [EC:1.1.1.27]
127437084  L-lactate dehydrogenase A chain-like [KO:K00016] [EC:1.1.1.27]
127432860  L-lactate dehydrogenase B-A chain-like [KO:K00016] [EC:1.1.1.27]
127435131  L-lactate dehydrogenase B-A chain-like [KO:K00016] [EC:1.1.1.27]
127435590  L-lactate dehydrogenase B-B chain isoform X1 [KO:K00016] [EC:1.1.1.27]
127435789  L-lactate dehydrogenase A chain [KO:K00016] [EC:1.1.1.27]
127444059  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
127445258  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
127410668  malate dehydrogenase 1Ab, NAD (soluble) [KO:K00025] [EC:1.1.1.37]
127454818  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
127432930  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
127433934  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
127455308  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
127411208  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
127447624  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
127448412  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
127431148  phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]
127437317  phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
masi00010  Glycolysis / Gluconeogenesis
masi00250  Alanine, aspartate and glutamate metabolism
masi00260  Glycine, serine and threonine metabolism
masi00290  Valine, leucine and isoleucine biosynthesis
masi00430  Taurine and hypotaurine metabolism
masi00480  Glutathione metabolism
masi00620  Pyruvate metabolism
masi00640  Propanoate metabolism
masi00770  Pantothenate and CoA biosynthesis
masi00900  Terpenoid backbone biosynthesis
masi00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

DBGET integrated database retrieval system