KEGG   PATHWAY: maua00260
Entry
maua00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Mesocricetus auratus (golden hamster)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
maua00260  Glycine, serine and threonine metabolism
maua00260

Module
maua_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:maua00260]
maua_M00047  Creatine pathway [PATH:maua00260]
maua_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:maua00260]
maua_M00555  Betaine biosynthesis, choline => betaine [PATH:maua00260]
maua_M00621  Glycine cleavage system [PATH:maua00260]
maua_M00974  Betaine metabolism, animals, betaine => glycine [PATH:maua00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Mesocricetus auratus (golden hamster) [GN:maua]
Gene
101842867  probable low-specificity L-threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
101839448  Shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
101833272  Shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
101836461  Agxt; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
101823575  Grhpr; glyoxylate reductase/hydroxypyruvate reductase isoform X2 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
101843061  Glyctk; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
121133188  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
101838267  Pgam1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
101824939  Pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
121140902  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
101840847  Bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
101835811  Phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
101836566  Psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
101835185  Psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
101827992  Gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform X1 [KO:K00639] [EC:2.3.1.29]
101842078  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
101838716  Alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
101822757  Alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
101825598  Maob; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
101825859  Maoa; amine oxidase [flavin-containing] A isoform X1 [KO:K00274] [EC:1.4.3.4]
101827582  membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
101825783  Gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
101839922  Amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
101831240  Dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
101830966  Gcsh; glycine cleavage system H protein, mitochondrial [KO:K02437]
101823212  Dao; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
101838780  Agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X2 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
101822558  Gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
101833877  Gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
101838507  Chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
101822560  Aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
101832592  Bhmt; betaine--homocysteine S-methyltransferase 1 isoform X1 [KO:K00544] [EC:2.1.1.5]
101825798  Dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
101828650  Pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
101837481  Sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
101825665  Gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
101827489  Cbs; cystathionine beta-synthase-like protein isoform X1 [KO:K01697] [EC:4.2.1.22]
101839943  Cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
101823717  Sds; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
101840196  Sdsl; LOW QUALITY PROTEIN: serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
101842588  Srr; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
maua00010  Glycolysis / Gluconeogenesis
maua00020  Citrate cycle (TCA cycle)
maua00230  Purine metabolism
maua00250  Alanine, aspartate and glutamate metabolism
maua00270  Cysteine and methionine metabolism
maua00290  Valine, leucine and isoleucine biosynthesis
maua00330  Arginine and proline metabolism
maua00470  D-Amino acid metabolism
maua00564  Glycerophospholipid metabolism
maua00600  Sphingolipid metabolism
maua00620  Pyruvate metabolism
maua00630  Glyoxylate and dicarboxylate metabolism
maua00640  Propanoate metabolism
maua00860  Porphyrin metabolism
maua00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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