KEGG   PATHWAY: mcha00230
Entry
mcha00230                   Pathway                                
Name
Purine metabolism - Momordica charantia (bitter melon)
Class
Metabolism; Nucleotide metabolism
Pathway map
mcha00230  Purine metabolism
mcha00230

Module
mcha_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mcha00230]
mcha_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mcha00230]
mcha_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mcha00230]
mcha_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mcha00230]
mcha_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mcha00230]
Other DBs
GO: 0006163 0042278
Organism
Momordica charantia (bitter melon) [GN:mcha]
Gene
111009099  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
111005951  nudix hydrolase 2-like [KO:K26956] [EC:3.6.1.13 3.6.1.22]
111008005  nudix hydrolase 2-like isoform X1 [KO:K26956] [EC:3.6.1.13 3.6.1.22]
111024856  nudix hydrolase 23, chloroplastic isoform X1 [KO:K18453] [EC:3.6.1.13 3.6.1.18]
111004513  nudix hydrolase 14, chloroplastic [KO:K18447] [EC:3.6.1.21]
111015614  phosphoglucomutase, cytoplasmic [KO:K01835] [EC:5.4.2.2]
111024329  phosphoglucomutase, chloroplastic [KO:K01835] [EC:5.4.2.2]
111022669  ribose-phosphate pyrophosphokinase 1-like [KO:K00948] [EC:2.7.6.1]
111025838  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
111015521  amidophosphoribosyltransferase, chloroplastic [KO:K00764] [EC:2.4.2.14]
111008277  phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
111022206  phosphoribosylglycinamide formyltransferase, chloroplastic [KO:K00601] [EC:2.1.2.2]
111015867  LOW QUALITY PROTEIN: probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial [KO:K01952] [EC:6.3.5.3]
111015874  probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial [KO:K01952] [EC:6.3.5.3]
111025154  phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial-like [KO:K01933] [EC:6.3.3.1]
111022739  phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial-like [KO:K01933] [EC:6.3.3.1]
111020171  phosphoribosylaminoimidazole carboxylase, chloroplastic isoform X1 [KO:K11808] [EC:4.1.1.21]
111005212  phosphoribosylaminoimidazole-succinocarboxamide synthase, chloroplastic [KO:K01923] [EC:6.3.2.6]
111023738  uncharacterized protein LOC111023738 isoform X1 [KO:K01756] [EC:4.3.2.2]
111009006  uncharacterized protein LOC111009006 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
111005136  adenine phosphoribosyltransferase 1-like [KO:K00759] [EC:2.4.2.7]
111004836  adenine phosphoribosyltransferase 5-like isoform X1 [KO:K00759] [EC:2.4.2.7]
111023363  adenine phosphoribosyltransferase 3-like [KO:K00759] [EC:2.4.2.7]
111021357  adenine phosphoribosyltransferase 3 [KO:K00759] [EC:2.4.2.7]
111009400  uncharacterized protein LOC111009400 [KO:K03787] [EC:3.1.3.5 3.1.3.6]
111020355  uncharacterized protein LOC111020355 [KO:K03787] [EC:3.1.3.5 3.1.3.6]
111006034  uncharacterized protein LOC111006034 [KO:K00760] [EC:2.4.2.8]
111016759  inosine-5'-monophosphate dehydrogenase 2-like [KO:K00088] [EC:1.1.1.205]
111020418  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
111008082  nucleoside diphosphate kinase 3-like [KO:K00940] [EC:2.7.4.6]
111008930  uncharacterized protein LOC111008930 [KO:K00940] [EC:2.7.4.6]
111014161  probable apyrase 6 [KO:K01510] [EC:3.6.1.5]
111021140  apyrase 2-like [KO:K14641] [EC:3.6.1.5]
111021142  apyrase 2-like [KO:K14641] [EC:3.6.1.5]
111023164  apyrase 2 [KO:K14641] [EC:3.6.1.5]
111016105  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
111021441  xanthine dehydrogenase 1-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111018292  nudix hydrolase 25 [KO:K26955] [EC:3.6.1.17]
111026060  uncharacterized protein LOC111026060 [KO:K01951] [EC:6.3.5.2]
111009480  guanylate kinase 3, chloroplastic [KO:K00942] [EC:2.7.4.8]
111019566  guanylate kinase 2-like [KO:K00942] [EC:2.7.4.8]
111005845  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
111017235  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
111009456  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
111006221  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
111015177  HD domain-containing protein C4G3.17 isoform X1 [KO:K07023] [EC:3.1.3.89]
111020874  HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
111015809  exopolyphosphatase PRUNE1-like isoform X1 [KO:K01514] [EC:3.6.1.11]
111020291  probable GTP diphosphokinase RSH2, chloroplastic [KO:K00951] [EC:2.7.6.5]
111009355  probable GTP diphosphokinase CRSH, chloroplastic [KO:K00951] [EC:2.7.6.5]
111014294  probable GTP diphosphokinase RSH3, chloroplastic [KO:K00951] [EC:2.7.6.5]
111022415  putative GTP diphosphokinase RSH1, chloroplastic isoform X1 [KO:K00951] [EC:2.7.6.5]
111021583  phytosulfokine receptor 1-like [KO:K27625] [EC:2.7.11.1 4.6.1.2]
111019542  adenylosuccinate synthetase 2, chloroplastic-like [KO:K01939] [EC:6.3.4.4]
111019553  adenylosuccinate synthetase 2, chloroplastic [KO:K01939] [EC:6.3.4.4]
111019491  AMP deaminase [KO:K01490] [EC:3.5.4.6]
111006504  adenosine kinase 2 [KO:K00856] [EC:2.7.1.20]
111014318  adenosine kinase 2-like [KO:K00856] [EC:2.7.1.20]
111010199  probable adenylate kinase 6, chloroplastic [KO:K00939] [EC:2.7.4.3]
111013727  adenylate kinase 1, chloroplastic [KO:K00939] [EC:2.7.4.3]
111006082  adenylate kinase, chloroplastic [KO:K00939] [EC:2.7.4.3]
111013160  adenylate kinase 5, chloroplastic isoform X1 [KO:K00939] [EC:2.7.4.3]
111007195  adenylate kinase 4-like [KO:K00939] [EC:2.7.4.3]
111021476  probable adenylate kinase 7, mitochondrial [KO:K00939] [EC:2.7.4.3]
111008637  probable adenylate kinase 7, mitochondrial [KO:K00939] [EC:2.7.4.3]
111009068  adenylate kinase 4 [KO:K00939] [EC:2.7.4.3]
111011355  adenylate kinase isoenzyme 6 homolog [KO:K18532] [EC:2.7.4.3]
111014875  cancer-related nucleoside-triphosphatase homolog isoform X1 [KO:K06928] [EC:3.6.1.15]
111021915  ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like [KO:K01513] [EC:3.1.4.1 3.6.1.9]
111014874  bifunctional bis(5'-adenosyl)-triphosphatase/adenylylsulfatase FHIT [KO:K01522] [EC:3.6.1.29]
111020419  bifunctional bis(5'-adenosyl)-triphosphatase/adenylylsulfatase FHIT-like isoform X1 [KO:K01522] [EC:3.6.1.29]
111009330  ATP sulfurylase 1, chloroplastic [KO:K13811] [EC:2.7.7.4 2.7.1.25]
111009889  ATP sulfurylase 1, chloroplastic-like [KO:K13811] [EC:2.7.7.4 2.7.1.25]
111006556  ATP sulfurylase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
111017750  adenylyl-sulfate kinase 3-like [KO:K00860] [EC:2.7.1.25]
111022948  adenylyl-sulfate kinase 3-like isoform X1 [KO:K00860] [EC:2.7.1.25]
111005892  adenylyl-sulfate kinase 3-like isoform X1 [KO:K00860] [EC:2.7.1.25]
111018658  uricase-2 [KO:K00365] [EC:1.7.3.3]
111016114  uric acid degradation bifunctional protein TTL isoform X1 [KO:K13484] [EC:3.5.2.17 4.1.1.97]
111010798  allantoinase [KO:K01466] [EC:3.5.2.5]
111008551  allantoate deiminase 2 isoform X1 [KO:K02083] [EC:3.5.3.9]
111022624  (S)-ureidoglycine aminohydrolase [KO:K14977] [EC:3.5.3.26]
111016352  ureidoglycolate hydrolase [KO:K18151] [EC:3.5.1.116]
111019692  urease-like [KO:K01427] [EC:3.5.1.5]
111019705  urease isoform X1 [KO:K01427] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mcha00030  Pentose phosphate pathway
mcha00220  Arginine biosynthesis
mcha00250  Alanine, aspartate and glutamate metabolism
mcha00260  Glycine, serine and threonine metabolism
mcha00340  Histidine metabolism
mcha00630  Glyoxylate and dicarboxylate metabolism
mcha00730  Thiamine metabolism
mcha00740  Riboflavin metabolism
mcha00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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