KEGG   PATHWAY: mdm00230
Entry
mdm00230                    Pathway                                
Name
Purine metabolism - Malus domestica (apple)
Class
Metabolism; Nucleotide metabolism
Pathway map
mdm00230  Purine metabolism
mdm00230

Module
mdm_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mdm00230]
mdm_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mdm00230]
mdm_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mdm00230]
mdm_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mdm00230]
mdm_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mdm00230]
Other DBs
GO: 0006163 0042278
Organism
Malus domestica (apple) [GN:mdm]
Gene
103455068  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
103408745  nudix hydrolase 2-like [KO:K26956] [EC:3.6.1.13 3.6.1.22]
103443062  nudix hydrolase 2-like [KO:K26956] [EC:3.6.1.13 3.6.1.22]
103405050  LOW QUALITY PROTEIN: nudix hydrolase 2-like [KO:K26956] [EC:3.6.1.13 3.6.1.22]
114819603  nudix hydrolase 10-like [KO:K26956] [EC:3.6.1.13 3.6.1.22]
103422534  nudix hydrolase 2 [KO:K26956] [EC:3.6.1.13 3.6.1.22]
103411488  nudix hydrolase 23, chloroplastic-like isoform X2 [KO:K18453] [EC:3.6.1.13 3.6.1.18]
114821097  nudix hydrolase 23, chloroplastic-like isoform X1 [KO:K18453] [EC:3.6.1.13 3.6.1.18]
114824351  nudix hydrolase 14, chloroplastic [KO:K18447] [EC:3.6.1.21]
103439907  LOW QUALITY PROTEIN: phosphoglucomutase, chloroplastic-like [KO:K01835] [EC:5.4.2.2]
103430692  phosphoglucomutase, cytoplasmic [KO:K01835] [EC:5.4.2.2]
103439690  phosphoglucomutase, chloroplastic-like [KO:K01835] [EC:5.4.2.2]
114820575  phosphoglucomutase, cytoplasmic-like [KO:K01835] [EC:5.4.2.2]
103438936  LOW QUALITY PROTEIN: ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
103407273  ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
103428170  ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
103429365  uncharacterized protein LOC103429365 [KO:K00948] [EC:2.7.6.1]
103445155  amidophosphoribosyltransferase, chloroplastic [KO:K00764] [EC:2.4.2.14]
114823663  amidophosphoribosyltransferase, chloroplastic-like [KO:K00764] [EC:2.4.2.14]
103421402  phosphoribosylamine--glycine ligase-like [KO:K01945] [EC:6.3.4.13]
103412552  phosphoribosylglycinamide formyltransferase, chloroplastic-like [KO:K00601] [EC:2.1.2.2]
103426016  phosphoribosylglycinamide formyltransferase, chloroplastic-like [KO:K00601] [EC:2.1.2.2]
103400609  LOW QUALITY PROTEIN: probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial [KO:K01952] [EC:6.3.5.3]
103415794  LOW QUALITY PROTEIN: probable phosphoribosylformylglycinamidine synthase, chloroplastic/mitochondrial [KO:K01952] [EC:6.3.5.3]
103435241  phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial-like [KO:K01933] [EC:6.3.3.1]
103441651  phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial-like isoform X2 [KO:K01933] [EC:6.3.3.1]
103441654  phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial-like [KO:K01933] [EC:6.3.3.1]
103410904  phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial-like [KO:K01933] [EC:6.3.3.1]
103421320  phosphoribosylformylglycinamidine cyclo-ligase, chloroplastic/mitochondrial-like [KO:K01933] [EC:6.3.3.1]
103434186  phosphoribosylaminoimidazole carboxylase, chloroplastic-like isoform X1 [KO:K11808] [EC:4.1.1.21]
103451046  phosphoribosylaminoimidazole carboxylase, chloroplastic-like isoform X2 [KO:K11808] [EC:4.1.1.21]
114823106  phosphoribosylaminoimidazole-succinocarboxamide synthase, chloroplastic-like [KO:K01923] [EC:6.3.2.6]
103401954  phosphoribosylaminoimidazole-succinocarboxamide synthase, chloroplastic [KO:K01923] [EC:6.3.2.6]
103424928  uncharacterized protein LOC103424928 [KO:K01756] [EC:4.3.2.2]
103449512  LOW QUALITY PROTEIN: uncharacterized protein LOC103449512 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
103454139  uncharacterized protein LOC103454139 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
103456217  adenine phosphoribosyltransferase 5-like isoform X1 [KO:K00759] [EC:2.4.2.7]
103455905  adenine phosphoribosyltransferase 1-like [KO:K00759] [EC:2.4.2.7]
103441475  adenine phosphoribosyltransferase 5-like isoform X1 [KO:K00759] [EC:2.4.2.7]
103441051  adenine phosphoribosyltransferase 1-like [KO:K00759] [EC:2.4.2.7]
103444025  adenine phosphoribosyltransferase 3 [KO:K00759] [EC:2.4.2.7]
103409565  adenine phosphoribosyltransferase 3 [KO:K00759] [EC:2.4.2.7]
103421117  adenine phosphoribosyltransferase 1, chloroplastic-like [KO:K00759] [EC:2.4.2.7]
103453576  uncharacterized protein LOC103453576 [KO:K03787] [EC:3.1.3.5 3.1.3.6]
103416137  uncharacterized protein LOC103416137 isoform X1 [KO:K03787] [EC:3.1.3.5 3.1.3.6]
103410284  uncharacterized protein LOC103410284 [KO:K03787] [EC:3.1.3.5 3.1.3.6]
103444719  uncharacterized protein LOC103444719 isoform X1 [KO:K00760] [EC:2.4.2.8]
103400362  uncharacterized protein LOC103400362 [KO:K00760] [EC:2.4.2.8]
103429615  inosine-5'-monophosphate dehydrogenase 2-like [KO:K00088] [EC:1.1.1.205]
103435530  inosine-5'-monophosphate dehydrogenase 2-like [KO:K00088] [EC:1.1.1.205]
103435364  inosine-5'-monophosphate dehydrogenase 2-like isoform X1 [KO:K00088] [EC:1.1.1.205]
103455035  nucleoside diphosphate kinase 2, chloroplastic [KO:K00940] [EC:2.7.4.6]
103437370  nucleoside diphosphate kinase III, chloroplastic/mitochondrial-like [KO:K00940] [EC:2.7.4.6]
103404467  nucleoside diphosphate kinase III, chloroplastic/mitochondrial-like [KO:K00940] [EC:2.7.4.6]
103439015  nucleoside diphosphate kinase 1 [KO:K00940] [EC:2.7.4.6]
114825364  nucleoside diphosphate kinase 2, chloroplastic-like [KO:K00940] [EC:2.7.4.6]
103448163  probable apyrase 6 isoform X2 [KO:K01510] [EC:3.6.1.5]
103451818  probable apyrase 6 isoform X2 [KO:K01510] [EC:3.6.1.5]
103431911  probable apyrase 6 isoform X1 [KO:K01510] [EC:3.6.1.5]
103428652  apyrase 2-like [KO:K14641] [EC:3.6.1.5]
103417106  apyrase 2-like [KO:K14641] [EC:3.6.1.5]
103453657  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
103440363  xanthine dehydrogenase 1-like isoform X2 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
103447973  xanthine dehydrogenase 1-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
103402591  nudix hydrolase 25 [KO:K26955] [EC:3.6.1.17]
114820663  nudix hydrolase 25-like [KO:K26955] [EC:3.6.1.17]
103415093  uncharacterized protein LOC103415093 [KO:K01951] [EC:6.3.5.2]
114825643  LOW QUALITY PROTEIN: uncharacterized protein LOC114825643 [KO:K01951] [EC:6.3.5.2]
103453053  guanylate kinase 2, chloroplastic/mitochondrial-like [KO:K00942] [EC:2.7.4.8]
103403826  guanylate kinase 2, chloroplastic/mitochondrial-like [KO:K00942] [EC:2.7.4.8]
103423260  guanylate kinase 2 isoform X1 [KO:K00942] [EC:2.7.4.8]
114821010  guanylate kinase 2-like [KO:K00942] [EC:2.7.4.8]
103413663  LOW QUALITY PROTEIN: guanylate kinase 3, chloroplastic-like [KO:K00942] [EC:2.7.4.8]
103401829  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
103418293  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
103453059  ribonucleoside-diphosphate reductase small chain A-like isoform X1 [KO:K10808] [EC:1.17.4.1]
103403833  ribonucleoside-diphosphate reductase small chain A-like isoform X1 [KO:K10808] [EC:1.17.4.1]
103442123  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
103432016  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
103452297  LOW QUALITY PROTEIN: HD domain-containing protein 2-like [KO:K07023] [EC:3.1.3.89]
103416471  LOW QUALITY PROTEIN: HD domain-containing protein C4G3.17-like [KO:K07023] [EC:3.1.3.89]
103425506  HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
103423490  exopolyphosphatase PRUNE1-like isoform X1 [KO:K01514] [EC:3.6.1.11]
103412331  exopolyphosphatase PRUNE1-like isoform X1 [KO:K01514] [EC:3.6.1.11]
103449161  putative GTP diphosphokinase RSH1, chloroplastic [KO:K00951] [EC:2.7.6.5]
103426071  probable GTP diphosphokinase RSH2, chloroplastic [KO:K00951] [EC:2.7.6.5]
103452613  probable GTP diphosphokinase CRSH, chloroplastic [KO:K00951] [EC:2.7.6.5]
103424155  probable GTP diphosphokinase RSH2, chloroplastic [KO:K00951] [EC:2.7.6.5]
103432613  putative GTP diphosphokinase RSH1, chloroplastic [KO:K00951] [EC:2.7.6.5]
103403435  phytosulfokine receptor 1 [KO:K27625] [EC:2.7.11.1 4.6.1.2]
103430679  LOW QUALITY PROTEIN: phytosulfokine receptor 1-like [KO:K27625] [EC:2.7.11.1 4.6.1.2]
103445175  adenylosuccinate synthetase 2, chloroplastic-like [KO:K01939] [EC:6.3.4.4]
103452756  adenylosuccinate synthetase 2, chloroplastic-like [KO:K01939] [EC:6.3.4.4]
103436466  adenylosuccinate synthetase 2, chloroplastic [KO:K01939] [EC:6.3.4.4]
103426006  AMP deaminase [KO:K01490] [EC:3.5.4.6]
103414308  AMP deaminase-like [KO:K01490] [EC:3.5.4.6]
103430423  AMP deaminase-like [KO:K01490] [EC:3.5.4.6]
103429705  adenosine kinase 2 [KO:K00856] [EC:2.7.1.20]
103440651  adenosine kinase 2-like [KO:K00856] [EC:2.7.1.20]
103430312  adenosine kinase 2 isoform X1 [KO:K00856] [EC:2.7.1.20]
103446931  probable adenylate kinase 6, chloroplastic [KO:K00939] [EC:2.7.4.3]
103451211  adenylate kinase 5, chloroplastic isoform X1 [KO:K00939] [EC:2.7.4.3]
103433341  adenylate kinase 1, chloroplastic-like [KO:K00939] [EC:2.7.4.3]
103408751  probable adenylate kinase 7, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
103404205  probable adenylate kinase 7, mitochondrial [KO:K00939] [EC:2.7.4.3]
103437557  adenylate kinase 4 [KO:K00939] [EC:2.7.4.3]
103415174  adenylate kinase 4 [KO:K00939] [EC:2.7.4.3]
103416306  adenylate kinase, chloroplastic [KO:K00939] [EC:2.7.4.3]
103417717  probable adenylate kinase 6, chloroplastic [KO:K00939] [EC:2.7.4.3]
114826312  adenylate kinase 2, chloroplastic-like [KO:K00939] [EC:2.7.4.3]
114819909  adenylate kinase 1, chloroplastic-like [KO:K00939] [EC:2.7.4.3]
103449836  adenylate kinase isoenzyme 6 homolog [KO:K18532] [EC:2.7.4.3]
103425028  cancer-related nucleoside-triphosphatase homolog isoform X1 [KO:K06928] [EC:3.6.1.15]
103450290  ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
103415864  LOW QUALITY PROTEIN: ectonucleotide pyrophosphatase/phosphodiesterase family member 3-like [KO:K01513] [EC:3.1.4.1 3.6.1.9]
103422756  bifunctional bis(5'-adenosyl)-triphosphatase/adenylylsulfatase FHIT-like [KO:K01522] [EC:3.6.1.29]
114823872  bifunctional bis(5'-adenosyl)-triphosphatase/adenylylsulfatase FHIT [KO:K01522] [EC:3.6.1.29]
103450392  ATP sulfurylase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
103403953  ATP sulfurylase 1, chloroplastic [KO:K13811] [EC:2.7.7.4 2.7.1.25]
103440334  ATP sulfurylase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
103410737  ATP sulfurylase 1, chloroplastic [KO:K13811] [EC:2.7.7.4 2.7.1.25]
103449306  adenylyl-sulfate kinase 3-like [KO:K00860] [EC:2.7.1.25]
103453878  adenylyl-sulfate kinase 3 isoform X2 [KO:K00860] [EC:2.7.1.25]
103401506  adenylyl-sulfate kinase 1, chloroplastic-like isoform X1 [KO:K00860] [EC:2.7.1.25]
103404032  adenylyl-sulfate kinase 3 isoform X1 [KO:K00860] [EC:2.7.1.25]
103436118  adenylyl-sulfate kinase 3-like [KO:K00860] [EC:2.7.1.25]
103419026  adenylyl-sulfate kinase 3-like [KO:K00860] [EC:2.7.1.25]
103438828  uricase-2 [KO:K00365] [EC:1.7.3.3]
103418481  uricase-2 isozyme 1-like [KO:K00365] [EC:1.7.3.3]
103412679  uric acid degradation bifunctional protein TTL isoform X1 [KO:K13484] [EC:3.5.2.17 4.1.1.97]
103446543  allantoinase [KO:K01466] [EC:3.5.2.5]
103434779  allantoinase [KO:K01466] [EC:3.5.2.5]
103446000  allantoate deiminase 2 [KO:K02083] [EC:3.5.3.9]
103431465  (S)-ureidoglycine aminohydrolase [KO:K14977] [EC:3.5.3.26]
103420203  (S)-ureidoglycine aminohydrolase-like [KO:K14977] [EC:3.5.3.26]
103414713  ureidoglycolate hydrolase [KO:K18151] [EC:3.5.1.116]
103452120  urease [KO:K01427] [EC:3.5.1.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mdm00030  Pentose phosphate pathway
mdm00220  Arginine biosynthesis
mdm00250  Alanine, aspartate and glutamate metabolism
mdm00260  Glycine, serine and threonine metabolism
mdm00340  Histidine metabolism
mdm00630  Glyoxylate and dicarboxylate metabolism
mdm00730  Thiamine metabolism
mdm00740  Riboflavin metabolism
mdm00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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