KEGG   PATHWAY: mdo04924
Entry
mdo04924                    Pathway                                
Name
Renin secretion - Monodelphis domestica (gray short-tailed opossum)
Description
The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. Renin is synthesized, stored in, and released into circulation by the juxtaglomerular (JG) cells of the kidney. Secretion of renin from JG cells at the organ level is controlled by the four main mechanisms: the sympathetic nervous system, the local JG apparatus baroreflex, the macula densa mechanism, and several hormones acting locally within the JG apparatus. Renin secretion at the level of renal JG cells appears to be controlled mainly by classic second messengers, namely cAMP, cGMP, and free cytosolic calcium concentration. While cAMP generally stimulates renin release and the intracellular calcium concentration suppresses the exocytosis of renin, the effects of cGMP in the regulation of the renin system are more complex as it both may stimulate or inhibit renin release.
Class
Organismal Systems; Endocrine system
Pathway map
mdo04924  Renin secretion
mdo04924

Other DBs
GO: 0002001
Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100027410  ADRB1; adrenoceptor beta 1 [KO:K04141]
100031542  ADRB2; adrenoceptor beta 2 [KO:K04142]
100032947  ADRB3; adrenoceptor beta 3 [KO:K04143]
100013888  ADCYAP1; adenylate cyclase activating polypeptide 1 [KO:K05262]
100029808  ADCYAP1R1; ADCYAP receptor type I [KO:K04587]
100029669  AQP1; aquaporin 1 (Colton blood group) [KO:K09864]
100015803  PTGER2; prostaglandin E receptor 2 [KO:K04259]
100018547  PTGER4; prostaglandin E receptor 4 [KO:K04261]
100021523  GNAS; GNAS complex locus [KO:K04632]
100029582  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
100019274  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
100011211  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
100026861  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100032298  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100014049  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
100013395  KCNMA1; potassium calcium-activated channel subfamily M alpha 1 [KO:K04936]
100027573  PDE1A; phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
100019026  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
100011746  PDE3A; phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
100029160  PDE3B; phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
100017048  renin-like [KO:K01380] [EC:3.4.23.15]
100016857  renin-like [KO:K01380] [EC:3.4.23.15]
100017089  renin-like [KO:K01380] [EC:3.4.23.15]
100618729  renin-1-like [KO:K01380] [EC:3.4.23.15]
100017009  renin-like [KO:K01380] [EC:3.4.23.15]
100017171  renin-like [KO:K01380] [EC:3.4.23.15]
100013052  GNAI1; G protein subunit alpha i1 [KO:K04630]
100030095  GNAI3; G protein subunit alpha i3 [KO:K04630]
100032986  GNAI2; G protein subunit alpha i2 [KO:K04630]
100015978  ORAI1; ORAI calcium release-activated calcium modulator 1 [KO:K16056]
100011439  CLCA1; chloride channel accessory 1 [KO:K05027]
100011294  calcium-activated chloride channel regulator 1 [KO:K05027]
100618928  calcium-activated chloride channel regulator 1-like [KO:K05027]
100009738  calcium-activated chloride channel regulator 1-like [KO:K05027]
100009811  calcium-activated chloride channel regulator 1-like [KO:K05027]
100009852  calcium-activated chloride channel regulator 1-like [KO:K05027]
100009888  calcium-activated chloride channel regulator 1-like [KO:K05027]
100009776  calcium-activated chloride channel regulator 1-like [KO:K05027]
100011495  CLCA2; chloride channel accessory 2 [KO:K05028]
100009933  epithelial chloride channel protein-like [KO:K05030]
100021421  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
100014450  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
100019531  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
100013684  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
100024208  KCNJ2; potassium voltage-gated channel subfamily J member 2 [KO:K04996]
100026601  EDN1; endothelin 1 [KO:K16366]
100032585  EDN2; endothelin 2 [KO:K16367]
100026909  EDN3; endothelin 3 [KO:K05227]
100018535  EDNRA; endothelin receptor type A [KO:K04197]
100017858  AGTR1; angiotensin II receptor type 1 [KO:K04166]
100011605  GNAQ; G protein subunit alpha q [KO:K04634]
100033281  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
100031660  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
100031869  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
100031263  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
100013305  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100010212  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100025596  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100021688  CALM3; calmodulin 3 [KO:K02183]
100018191  CALM1; calmodulin 1 [KO:K02183]
100032171  CALM2; calmodulin 2 [KO:K02183]
100025795  CALML4; calmodulin like 4 [KO:K02183]
100015722  calmodulin-alpha-like [KO:K02183]
100022649  calmodulin-alpha-like [KO:K02183]
100014900  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100011077  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
100033104  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
100033302  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
100017038  GUCY1A3; guanylate cyclase 1 soluble subunit alpha [KO:K12318] [EC:4.6.1.2]
100027037  GUCY1A2; guanylate cyclase 1 soluble subunit alpha 2 [KO:K12318] [EC:4.6.1.2]
100028289  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
100024008  GUCY1B3; guanylate cyclase 1 soluble subunit beta [KO:K12319] [EC:4.6.1.2]
100018089  NPPA; natriuretic peptide A [KO:K12334]
100019736  NPR1; natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
100014568  PRKG2; protein kinase, cGMP-dependent, type II [KO:K19477] [EC:2.7.11.12]
100032681  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
100029465  AGT; angiotensinogen [KO:K09821]
100025797  ACE; angiotensin I converting enzyme [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00020  AMP
C00076  Calcium cation
C00212  Adenosine
C00238  Potassium cation
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00788  L-Adrenaline
C00873  Angiotensin I
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02135  Angiotensin II
Reference
PMID:20936939
  Authors
Kurtz A
  Title
Renin release: sites, mechanisms, and control.
  Journal
Annu Rev Physiol 73:377-99 (2011)
DOI:10.1146/annurev-physiol-012110-142238
Reference
PMID:17928544
  Authors
Schweda F, Friis U, Wagner C, Skott O, Kurtz A
  Title
Renin release.
  Journal
Physiology (Bethesda) 22:310-9 (2007)
DOI:10.1152/physiol.00024.2007
Reference
PMID:20393195
  Authors
Castrop H, Hocherl K, Kurtz A, Schweda F, Todorov V, Wagner C
  Title
Physiology of kidney renin.
  Journal
Physiol Rev 90:607-73 (2010)
DOI:10.1152/physrev.00011.2009
Reference
PMID:22733355
  Authors
Friis UG, Madsen K, Stubbe J, Hansen PB, Svenningsen P, Bie P, Skott O, Jensen BL
  Title
Regulation of renin secretion by renal juxtaglomerular cells.
  Journal
Pflugers Arch 465:25-37 (2013)
DOI:10.1007/s00424-012-1126-7
Reference
PMID:22124804
  Authors
Kim SM, Briggs JP, Schnermann J
  Title
Convergence of major physiological stimuli for renin release on the Gs-alpha/cyclic adenosine monophosphate signaling pathway.
  Journal
Clin Exp Nephrol 16:17-24 (2012)
DOI:10.1007/s10157-011-0494-1
Reference
PMID:22237158
  Authors
Kurtz A
  Title
Control of renin synthesis and secretion.
  Journal
Am J Hypertens 25:839-47 (2012)
DOI:10.1038/ajh.2011.246
Reference
PMID:9882634
  Authors
Kurtz A, Wagner C
  Title
Cellular control of renin secretion.
  Journal
J Exp Biol 202:219-25 (1999)
Reference
PMID:12949225
  Authors
Persson PB
  Title
Renin: origin, secretion and synthesis.
  Journal
J Physiol 552:667-71 (2003)
DOI:10.1113/jphysiol.2003.049890
Reference
PMID:15283749
  Authors
Schweda F, Kurtz A
  Title
Cellular mechanism of renin release.
  Journal
Acta Physiol Scand 181:383-90 (2004)
DOI:10.1111/j.1365-201X.2004.01309.x
Reference
PMID:24944035
  Authors
Sparks MA, Crowley SD, Gurley SB, Mirotsou M, Coffman TM
  Title
Classical Renin-Angiotensin system in kidney physiology.
  Journal
Compr Physiol 4:1201-28 (2014)
DOI:10.1002/cphy.c130040
Reference
PMID:19948673
  Authors
Harrison-Bernard LM
  Title
The renal renin-angiotensin system.
  Journal
Adv Physiol Educ 33:270-4 (2009)
DOI:10.1152/advan.00049.2009
Reference
PMID:22258323
  Authors
Schnermann J, Briggs JP
  Title
Synthesis and secretion of renin in mice with induced genetic mutations.
  Journal
Kidney Int 81:529-38 (2012)
DOI:10.1038/ki.2011.451
Reference
PMID:12388321
  Authors
Ryan MJ, Black TA, Millard SL, Gross KW, Hajduczok G
  Title
Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells.
  Journal
Am J Physiol Heart Circ Physiol 283:H2458-65 (2002)
DOI:10.1152/ajpheart.00295.2002
Reference
PMID:17360952
  Authors
Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schutz G, Schweda F
  Title
Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors.
  Journal
J Am Soc Nephrol 18:1150-6 (2007)
DOI:10.1681/ASN.2006060633
Related
pathway
mdo04020  Calcium signaling pathway
mdo04022  cGMP-PKG signaling pathway
mdo04024  cAMP signaling pathway
mdo04614  Renin-angiotensin system
KO pathway
ko04924   
LinkDB

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