KEGG   PATHWAY: mfot04142
Entry
mfot04142                   Pathway                                
Name
Lysosome - Microtus fortis (reed vole)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
mfot04142  Lysosome
mfot04142

Other DBs
GO: 0005764
Organism
Microtus fortis (reed vole) [GN:mfot]
Gene
126510301  V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
126504303  V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
126498188  V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
126505211  V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
126502654  V-type proton ATPase subunit d 1 [KO:K02146]
126516099  V-type proton ATPase subunit d 2 [KO:K02146]
126515563  V-type proton ATPase subunit H isoform X1 [KO:K02144]
126490265  V-type proton ATPase subunit S1 [KO:K03662]
126497885  V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
126513167  V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
126505967  dmX-like protein 1 isoform X1 [KO:K24155]
126486905  dmX-like protein 2 isoform X1 [KO:K24155]
126511078  WD repeat-containing protein 7 [KO:K24738]
126499062  nuclear receptor coactivator 7 isoform X1 [KO:K25442]
126506882  lysosomal protective protein isoform X1 [KO:K13289] [EC:3.4.16.5]
126507571  cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
126491508  dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
126498544  cathepsin D [KO:K01379] [EC:3.4.23.5]
126505035  cathepsin E [KO:K01382] [EC:3.4.23.34]
126498751  cathepsin F [KO:K01373] [EC:3.4.22.41]
126492602  cathepsin G-like [KO:K01319] [EC:3.4.21.20]
126510630  pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
126502966  cathepsin J-like [KO:K09599] [EC:3.4.22.-]
126489972  cathepsin K isoform X1 [KO:K01371] [EC:3.4.22.38]
126502700  procathepsin L [KO:K01365] [EC:3.4.22.15]
126502915  cathepsin M-like [KO:K09600] [EC:3.4.22.-]
126511546  cathepsin O [KO:K01374] [EC:3.4.22.42]
126490028  cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
126498862  cathepsin W [KO:K08569] [EC:3.4.22.-]
126508021  cathepsin Z [KO:K08568] [EC:3.4.18.1]
126488093  napsin-A [KO:K08565] [EC:3.4.23.-]
126507217  legumain [KO:K01369] [EC:3.4.22.34]
126494111  tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
126493556  alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
126503230  LOW QUALITY PROTEIN: alpha-galactosidase A-like [KO:K01189] [EC:3.2.1.22]
126499841  beta-galactosidase [KO:K12309] [EC:3.2.1.23]
126500433  lysosomal alpha-glucosidase isoform X1 [KO:K12316] [EC:3.2.1.20]
126516159  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
126509631  alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
126515716  alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
126510396  alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
126507178  galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
126504201  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
126512194  LOW QUALITY PROTEIN: tissue alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
126507792  tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
126488632  plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
126507439  beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
126508505  beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
126509568  beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
126487747  lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
126495385  sialidase-1 [KO:K01186] [EC:3.2.1.18]
126499790  hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
126499851  hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
126499853  hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
126503930  hyaluronidase-5-like [KO:K01197] [EC:3.2.1.35]
126503932  hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
126503950  hyaluronidase PH-20-like [KO:K01197] [EC:3.2.1.35]
126503951  hyaluronidase PH-20-like [KO:K01197] [EC:3.2.1.35]
126503952  hyaluronidase-like [KO:K01197] [EC:3.2.1.35]
126493324  arylsulfatase A isoform X1 [KO:K01134] [EC:3.1.6.8]
126508549  arylsulfatase B [KO:K01135] [EC:3.1.6.12]
126514939  arylsulfatase G isoform X1 [KO:K12381] [EC:3.1.6.-]
126515499  N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
126515652  N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
126492688  iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
126500377  N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
126511215  lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
126502742  phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
126512378  deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
126487789  deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
126489767  lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
126490565  LOW QUALITY PROTEIN: tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
126494100  sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
126504764  acid ceramidase isoform X1 [KO:K12348] [EC:3.5.1.23]
126504797  N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1 [KO:K01444] [EC:3.5.1.26]
126498974  prosaposin isoform X1 [KO:K12382]
126500925  proactivator polypeptide-like 1 [KO:K12382]
126510956  ganglioside GM2 activator [KO:K12383]
126513172  palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
126495186  lysosomal thioesterase PPT2 [KO:K01074] [EC:3.1.2.22]
126498638  lysosome-associated membrane glycoprotein 1 [KO:K06528]
126494668  lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
126494569  lysosome-associated membrane glycoprotein 3 [KO:K06562]
126513930  LOW QUALITY PROTEIN: macrosialin [KO:K06501]
126492063  CD63 antigen [KO:K06497]
126506378  lysosome membrane protein 2 [KO:K12384]
126512792  NPC intracellular cholesterol transporter 1 isoform X1 [KO:K12385]
126515138  NPC intracellular cholesterol transporter 2 [KO:K13443]
126514108  cystinosin isoform X1 [KO:K12386]
126491076  sialin isoform X1 [KO:K12301]
126492947  natural resistance-associated macrophage protein 1 isoform X1 [KO:K12347]
126488777  natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
126507245  lysosomal-associated transmembrane protein 5 [KO:K12387]
126513926  lysosomal-associated transmembrane protein 4B [KO:K12387]
126501301  lysosomal-associated transmembrane protein 4A [KO:K12387]
126509302  ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
126504329  ABC-type oligopeptide transporter ABCB9 [KO:K05656]
126487601  sialomucin core protein 24 isoform X1 [KO:K06546]
126488394  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
126487893  sortilin isoform X1 [KO:K12388]
126488243  battenin isoform X1 [KO:K12389]
126503157  ceroid-lipofuscinosis neuronal protein 5 isoform X1 [KO:K12390]
126499194  major facilitator superfamily domain-containing protein 8 [KO:K12307]
126504436  heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
126506092  formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
126503848  N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
126487726  N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X1 [KO:K10087]
126498201  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
126497712  cation-independent mannose-6-phosphate receptor [KO:K06564]
126514838  cation-dependent mannose-6-phosphate receptor [KO:K10089]
126509928  clathrin light chain A [KO:K04644]
126502634  clathrin light chain B isoform X1 [KO:K04645]
126486973  clathrin heavy chain 1 isoform X1 [KO:K04646]
126502485  AP-1 complex subunit gamma-1 [KO:K12391]
126490880  AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
126500793  AP-1 complex subunit beta-1 [KO:K12392]
126492211  AP-1 complex subunit mu-1 [KO:K12393]
126490554  AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
126491917  AP-1 complex subunit sigma-1A isoform X1 [KO:K12394]
126512706  AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
126512967  AP-1 complex subunit sigma-3 [KO:K12395]
126489211  AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
126508554  AP-3 complex subunit beta-1 [KO:K12397]
126508718  AP-3 complex subunit beta-2 [KO:K12397]
126504502  AP-3 complex subunit mu-2 [KO:K12398]
126491406  AP-3 complex subunit mu-1 [KO:K12398]
126506019  AP-3 complex subunit sigma-1 [KO:K12399]
126508619  AP-3 complex subunit sigma-2 isoform X1 [KO:K12399]
126494326  AP-4 complex subunit epsilon-1 [KO:K12400]
126510786  AP-4 complex subunit beta-1 [KO:K12401]
126492993  AP-4 complex subunit mu-1 [KO:K12402]
126500399  ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
126502384  ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
126515803  ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
126491600  mucolipin-1 isoform X1 [KO:K04992]
126491597  lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
mfot00511  Other glycan degradation
mfot00531  Glycosaminoglycan degradation
mfot04130  SNARE interactions in vesicular transport
mfot04140  Autophagy - animal
mfot04144  Endocytosis
KO pathway
ko04142   
LinkDB

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