KEGG   PATHWAY: mfot04727
Entry
mfot04727                   Pathway                                
Name
GABAergic synapse - Microtus fortis (reed vole)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
mfot04727  GABAergic synapse
mfot04727

Other DBs
GO: 0051932
Organism
Microtus fortis (reed vole) [GN:mfot]
Gene
126494061  sodium-coupled neutral amino acid transporter 1 [KO:K14990]
126492649  sodium-coupled neutral amino acid transporter 2 isoform X1 [KO:K14207]
126511874  glutaminase kidney isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
126492025  glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
126507900  glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
126488377  glutamate decarboxylase 1 isoform X1 [KO:K01580] [EC:4.1.1.15]
126506812  vesicular inhibitory amino acid transporter [KO:K15015]
126498063  4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
126506188  gamma-aminobutyric acid receptor subunit alpha-4 isoform X1 [KO:K05175]
126506191  gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
126499427  gamma-aminobutyric acid receptor subunit alpha-6 isoform X1 [KO:K05175]
126499500  gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
126500434  gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
126489409  gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
126506190  gamma-aminobutyric acid receptor subunit beta-1 isoform X1 [KO:K05181]
126499432  gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
126500425  gamma-aminobutyric acid receptor subunit beta-3 [KO:K05181]
126499501  gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
126506438  gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
126500543  gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
126489410  gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
126489390  gamma-aminobutyric acid receptor subunit theta isoform X1 [KO:K05192]
126499519  gamma-aminobutyric acid receptor subunit pi isoform X1 [KO:K05189]
126512376  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
126512697  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
126487741  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
126507045  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
126514970  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
126502354  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126493096  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126510351  huntingtin-associated protein 1 isoform X1 [KO:K04647]
126493241  gamma-aminobutyric acid receptor-associated protein-like 1 isoform X1 [KO:K08341]
126513891  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
126502223  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
126502556  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
126509523  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
126489728  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
126487544  vesicle-fusing ATPase isoform X1 [KO:K06027] [EC:3.6.4.6]
126511773  LOW QUALITY PROTEIN: trafficking kinesin-binding protein 2 [KO:K15374]
126511815  inactive phospholipase C-like protein 1 [KO:K15375]
126511449  gephyrin [KO:K15376] [EC:2.10.1.1 2.7.7.75]
126506957  solute carrier family 12 member 5 [KO:K23967]
126505766  gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
126503655  gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
126503663  gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190]
126487773  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
126500249  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
126505446  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
126511130  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
126512843  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
126505025  voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
126494271  gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
126509791  gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
126512093  guanine nucleotide-binding protein G(i) subunit alpha-3-like [KO:K04630]
126499907  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
126500134  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
126487932  guanine nucleotide-binding protein G(i) subunit alpha-3 isoform X1 [KO:K04630]
126502958  guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
126493216  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
126493984  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
126514867  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
126499250  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
126491703  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
126507651  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
126515642  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2-like [KO:K07826]
126491401  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
126498502  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1 [KO:K04540]
126501666  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
126505515  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126499229  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126512384  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
126487356  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126489684  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
126489890  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126489349  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
126494797  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
126515228  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126493569  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
126493349  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
126512992  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
126493570  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
126510518  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
126500995  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
126503179  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
126490736  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
126490851  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
126512151  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
126493775  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
126487138  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
126503596  adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
126492532  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
126513590  G protein-activated inward rectifier potassium channel 2 [KO:K05000]
126505556  sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
126514818  sodium- and chloride-dependent GABA transporter 2 [KO:K05046]
126505504  sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
126514816  sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045]
126493277  LOW QUALITY PROTEIN: glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
126497367  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
126499885  sodium-coupled neutral amino acid transporter 3 [KO:K13576]
126512879  sodium-coupled neutral amino acid transporter 5 isoform X1 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
mfot00020  Citrate cycle (TCA cycle)
mfot00250  Alanine, aspartate and glutamate metabolism
mfot04144  Endocytosis
mfot04721  Synaptic vesicle cycle
KO pathway
ko04727   
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