KEGG PATHWAY: mgp00260

PATHWAY: mgp00260

Entry

mgp00260                    Pathway

Name

Glycine, serine and threonine metabolism - Meleagris gallopavo (turkey)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

mgp00260

Glycine, serine and threonine metabolism

Module

mgp_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:mgp00260]

mgp_M00047

Creatine pathway [PATH:mgp00260]

mgp_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mgp00260]

mgp_M00555

Betaine biosynthesis, choline => betaine [PATH:mgp00260]

mgp_M00621

Glycine cleavage system [PATH:mgp00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Meleagris gallopavo (turkey) [GN:mgp]

Gene

100547437

probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]

100545847

SHMT1; serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]

104916864

serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]

100543344

AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

100549242

GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

100549635

GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]

100549320

PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]

100546129

BPGM; bisphosphoglycerate mutase isoform X2 [KO:K01837] [EC:5.4.2.4 5.4.2.11]

100540490

PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

100544529

PSAT1; phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]

100546058

PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

100540315

GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

100544436

L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]

100547950

ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]

100540365

amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]

100540209

amine oxidase [flavin-containing] B-like [KO:K00274] [EC:1.4.3.4]

100548064

LOW QUALITY PROTEIN: membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]

100550110

GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

100549298

AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

100548628

DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

100548915

GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]

100538439

DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]

100541842

AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]

100542487

GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

100544992

GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

100544352

CHDH; LOW QUALITY PROTEIN: choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

104915364

ALDH7A1; LOW QUALITY PROTEIN: alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

100541641

betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]

100540414

PIPOX; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]

100544931

SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

100540940

GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

100550886

cystathionine beta-synthase-like isoform X1 [KO:K01697] [EC:4.2.1.22]

100551038

cystathionine beta-synthase isoform X2 [KO:K01697] [EC:4.2.1.22]

100541672

CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

100538632

uncharacterized protein LOC100538632 isoform X2 [KO:K01754] [EC:4.3.1.19]

100539678

serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

100540386

uncharacterized protein LOC100540386 [KO:K20498] [EC:4.3.1.18]

100542246

SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721