KEGG   PATHWAY: mgp03040
Entry
mgp03040                    Pathway                                
Name
Spliceosome - Meleagris gallopavo (turkey)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
mgp03040  Spliceosome
mgp03040

Other DBs
GO: 0005681
Organism
Meleagris gallopavo (turkey) [GN:mgp]
Gene
116216386  U1 spliceosomal RNA [KO:K14276]
116216950  U1 spliceosomal RNA [KO:K14276]
116216217  U2 spliceosomal RNA [KO:K14277]
116217794  U2 spliceosomal RNA [KO:K14277]
116217278  U4 spliceosomal RNA [KO:K14278]
116217279  U4 spliceosomal RNA [KO:K14278]
116216221  U5 spliceosomal RNA [KO:K14279]
116217025  U5 spliceosomal RNA [KO:K14279]
116217019  U5 spliceosomal RNA [KO:K14279]
116217008  U5 spliceosomal RNA [KO:K14279]
116216389  U6 spliceosomal RNA [KO:K14280]
116217333  U6 spliceosomal RNA [KO:K14280]
116216390  U6 spliceosomal RNA [KO:K14280]
116217186  U6 spliceosomal RNA [KO:K14280]
100545846  DDX46; probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
100549892  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
100543760  pre-mRNA-processing factor 17 [KO:K12816]
100550319  PRPF18; pre-mRNA-splicing factor 18 isoform X2 [KO:K12817]
100547655  DHX8; ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
100548049  SLU7; pre-mRNA-splicing factor SLU7 isoform X1 [KO:K12819]
100541861  DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
100548671  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086]
100542430  SNRPD1; LOW QUALITY PROTEIN: small nuclear ribonucleoprotein Sm D1 [KO:K11087]
100546573  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
100543644  SNRPE; small nuclear ribonucleoprotein E [KO:K11097]
100547816  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
100545616  SNRPG; small nuclear ribonucleoprotein G [KO:K11099]
100544208  SNRPC; U1 small nuclear ribonucleoprotein C isoform X2 [KO:K11095]
100544090  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
100548903  RBM25; RNA-binding protein 25 isoform X1 [KO:K12822]
100542962  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
100539005  TCERG1; transcription elongation regulator 1 [KO:K12824]
100540341  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
100549761  SNRPB2; U2 small nuclear ribonucleoprotein B'' isoform X1 [KO:K11094]
100540566  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
100546222  SF3A2; splicing factor 3A subunit 2 [KO:K12826]
104915633  LOW QUALITY PROTEIN: splicing factor 3A subunit 2-like [KO:K12826]
100539377  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
100547422  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
100543885  SF3B3; splicing factor 3B subunit 3 isoform X1 [KO:K12830]
100550414  SF3B4; splicing factor 3B subunit 4 [KO:K12831]
100549306  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
100544383  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
100544320  PHF5A; PHD finger-like domain-containing protein 5A [KO:K12834]
100543184  DDX42; ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
100551194  U2AF1; splicing factor U2AF 35 kDa subunit [KO:K12836]
100543974  PUF60; poly(U)-binding-splicing factor PUF60 isoform X3 [KO:K12838]
100545023  SMNDC1; survival of motor neuron-related-splicing factor 30 [KO:K12839]
100547305  RBM17; splicing factor 45 isoform X1 [KO:K12840]
100540045  CHERP; calcium homeostasis endoplasmic reticulum protein [KO:K12841]
100543105  U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
100551311  RP9; retinitis pigmentosa 9 protein [KO:K19604]
100546610  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
100549544  LSM4; U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
100550547  LSM5; U6 snRNA-associated Sm-like protein LSm5 isoform X1 [KO:K12624]
100544905  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
100550366  LSM7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
100543190  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
100539116  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
100548768  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
100548462  PPIH; peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
100546935  SNU13; NHP2-like protein 1 [KO:K12845]
100544419  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
104915963  USP39; U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
100547076  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
100541671  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
100539823  PRPF38B; pre-mRNA-splicing factor 38B [KO:K12850]
100549751  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
100541104  SNRNP200; LOW QUALITY PROTEIN: U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
100550775  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
100551124  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
100541327  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
104915900  DDX23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
100542679  TXNL4A; thioredoxin-like protein 4A [KO:K12859]
100539504  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
104909245  cell division cycle 5-like protein [KO:K12860]
104914534  BCAS2; pre-mRNA-splicing factor SPF27 [KO:K12861]
100546596  PLRG1; pleiotropic regulator 1 [KO:K12862]
100546636  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
100538553  CTNNBL1; beta-catenin-like protein 1 isoform X2 [KO:K12864]
100551334  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
100539894  WBP11; WW domain-binding protein 11 [KO:K12866]
100546954  SNW1; SNW domain-containing protein 1 [KO:K06063]
100549797  SYF2; pre-mRNA-splicing factor SYF2 [KO:K12868]
100543603  CRNKL1; crooked neck-like protein 1 [KO:K12869]
100541879  ISY1; pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
104916355  PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
100550932  PPIE; peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
100539148  CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871]
100548506  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
100539986  BUD31; protein BUD31 homolog [KO:K12873]
100545883  AQR; RNA helicase aquarius [KO:K12874]
100541698  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
104915819  RNA-binding protein 8A [KO:K12876]
100541520  MAGOH; protein mago nashi homolog [KO:K12877]
100538518  THOC1; THO complex subunit 1 [KO:K12878]
100542078  THOC2; LOW QUALITY PROTEIN: THO complex subunit 2 [KO:K12879]
100541161  THOC3; THO complex subunit 3 [KO:K12880]
100545751  ALYREF; THO complex subunit 4 [KO:K12881]
100543699  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
100544502  nuclear cap-binding protein subunit 2 [KO:K12883]
100544974  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
100546559  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
100538921  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
100547175  RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885]
104915105  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X3 [KO:K12886]
100550825  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887]
100543968  HNRNPU; heterogeneous nuclear ribonucleoprotein U [KO:K12888]
100548975  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
100541381  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
100547039  SRSF4; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 4 [KO:K12893]
100550929  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
100549826  serine/arginine-rich splicing factor 5-like [KO:K12893]
100538990  SRSF5; serine/arginine-rich splicing factor 5 [KO:K12893]
100542161  serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896]
104909563  serine/arginine-rich splicing factor 7-like [KO:K12896]
104915840  serine/arginine-rich splicing factor 7 [KO:K12896]
100549980  TRA2A; transformer-2 protein homolog alpha [KO:K12897]
100540335  TRA2B; transformer-2 protein homolog beta [KO:K12897]
100541075  SRSF10; serine/arginine-rich splicing factor 10 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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