KEGG   PATHWAY: ming00270
Entry
ming00270                   Pathway                                
Name
Cysteine and methionine metabolism - Macadamia integrifolia (macadamia nut)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
ming00270  Cysteine and methionine metabolism
ming00270

Module
ming_M00021  Cysteine biosynthesis, serine => cysteine [PATH:ming00270]
ming_M00034  Methionine salvage pathway [PATH:ming00270]
ming_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:ming00270]
Other DBs
GO: 0006534 0006555
Organism
Macadamia integrifolia (macadamia nut) [GN:ming]
Gene
122078533  serine acetyltransferase 5-like isoform X1 [KO:K00640] [EC:2.3.1.30]
122092781  serine acetyltransferase 5-like [KO:K00640] [EC:2.3.1.30]
122083289  serine acetyltransferase 2-like [KO:K00640] [EC:2.3.1.30]
122058058  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
122059292  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
122089975  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
122092054  cysteine synthase [KO:K01738] [EC:2.5.1.47]
122093167  cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
122094268  cysteine synthase, chloroplastic/chromoplastic [KO:K01738] [EC:2.5.1.47]
122066723  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial-like [KO:K13034] [EC:2.5.1.47 4.4.1.9]
122075314  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial-like isoform X1 [KO:K13034] [EC:2.5.1.47 4.4.1.9]
122075315  bifunctional L-3-cyanoalanine synthase/cysteine synthase 2, mitochondrial-like [KO:K13034] [EC:2.5.1.47 4.4.1.9]
122080917  cystathionine beta-lyase, chloroplastic [KO:K01760] [EC:4.4.1.13]
122061685  homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
122078951  homocysteine S-methyltransferase 1-like [KO:K00547] [EC:2.1.1.10]
122069465  homocysteine S-methyltransferase 2-like [KO:K00547] [EC:2.1.1.10]
122070211  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
122087023  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase-like [KO:K00549] [EC:2.1.1.14]
122091885  S-adenosylmethionine synthase 5-like [KO:K00789] [EC:2.5.1.6]
122082595  S-adenosylmethionine synthase 1-like [KO:K00789] [EC:2.5.1.6]
122058023  S-adenosylmethionine synthase 5 [KO:K00789] [EC:2.5.1.6]
122058196  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
122074596  S-adenosylmethionine synthase 1-like [KO:K00789] [EC:2.5.1.6]
122089288  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
122091969  S-adenosylmethionine decarboxylase proenzyme 4-like [KO:K01611] [EC:4.1.1.50]
122080860  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
122069060  LOW QUALITY PROTEIN: S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
122058289  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
122075772  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
122077746  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
122080744  spermine synthase-like isoform X1 [KO:K00797] [EC:2.5.1.16]
122082707  spermine synthase [KO:K00797] [EC:2.5.1.16]
122090294  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
122091275  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
122085701  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
122083366  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase-like [KO:K01244] [EC:3.2.2.16]
122073332  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase-like [KO:K01244] [EC:3.2.2.16]
122073333  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase-like [KO:K01244] [EC:3.2.2.16]
122081798  methylthioribose kinase 1 [KO:K00899] [EC:2.7.1.100]
122066139  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
122089261  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 isoform X1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
122094345  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 1 isoform X1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
122091478  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
122091479  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
122073306  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
122073885  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
122067517  probable N-succinyldiaminopimelate aminotransferase DapC [KO:K23977] [EC:2.6.1.117]
122080293  probable aminotransferase TAT2 isoform X1 [KO:K00815] [EC:2.6.1.5]
122083545  nicotianamine aminotransferase 1-like isoform X1 [KO:K00815] [EC:2.6.1.5]
122084327  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
122064625  aromatic aminotransferase ISS1-like [KO:K00837] [EC:2.6.1.-]
122071044  aromatic aminotransferase ISS1-like [KO:K00837] [EC:2.6.1.-]
122060499  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
122061124  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
122088832  methionine gamma-lyase-like isoform X1 [KO:K01761] [EC:4.4.1.11]
122089180  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
122077792  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
122090851  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
122080622  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
122067489  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
122083243  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
122061446  putative DNA (cytosine-5)-methyltransferase CMT1 isoform X1 [KO:K00558] [EC:2.1.1.37]
122070164  DNA (cytosine-5)-methyltransferase 1A-like [KO:K00558] [EC:2.1.1.37]
122073819  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
122082029  uncharacterized protein LOC122082029 [KO:K17398] [EC:2.1.1.37]
122067505  adenosylhomocysteinase-like [KO:K01251] [EC:3.13.2.1]
122070398  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
122072715  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
122082565  1-aminocyclopropane-1-carboxylate synthase-like isoform X1 [KO:K20772] [EC:4.4.1.14]
122082576  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
122082639  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
122070970  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
122072217  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
122072252  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
122085510  1-aminocyclopropane-1-carboxylate synthase 7-like isoform X1 [KO:K01762] [EC:4.4.1.14]
122069649  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
122083118  1-aminocyclopropane-1-carboxylate oxidase 5-like [KO:K05933] [EC:1.14.17.4]
122083290  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
122057709  1-aminocyclopropane-1-carboxylate oxidase 5-like [KO:K05933] [EC:1.14.17.4]
122075434  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
122087417  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
122079537  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
122080393  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
122076938  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
122077062  LOW QUALITY PROTEIN: aspartate-semialdehyde dehydrogenase-like [KO:K00133] [EC:1.2.1.11]
122078422  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
122076661  cystathionine gamma-synthase 1, chloroplastic-like [KO:K01739] [EC:2.5.1.48]
122064687  cystathionine gamma-synthase 1, chloroplastic-like [KO:K01739] [EC:2.5.1.48]
122065004  branched-chain-amino-acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
122066127  branched-chain amino acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
122071864  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
122087601  branched-chain-amino-acid aminotransferase 5, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
122088751  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122089942  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122081585  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122093975  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
122092163  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
122092165  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
122068137  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
122057340  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
122061623  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
122063455  aspartate aminotransferase, mitochondrial-like isoform X1 [KO:K14455] [EC:2.6.1.1]
122066993  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
122057079  aspartate aminotransferase, chloroplastic [KO:K00811] [EC:2.6.1.1]
122060208  thiosulfate/3-mercaptopyruvate sulfurtransferase 2-like isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
122093747  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
122079045  L-lactate dehydrogenase A-like [KO:K00016] [EC:1.1.1.27]
122080814  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
122078617  D-cysteine desulfhydrase 2, mitochondrial-like isoform X1 [KO:K05396] [EC:4.4.1.15]
122080523  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial-like [KO:K05396] [EC:4.4.1.15]
122067394  D-cysteine desulfhydrase 2, mitochondrial-like isoform X1 [KO:K05396] [EC:4.4.1.15]
122057865  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
122088862  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
122081728  malate dehydrogenase-like isoform X1 [KO:K00025] [EC:1.1.1.37]
122086045  malate dehydrogenase-like isoform X1 [KO:K00025] [EC:1.1.1.37]
122089263  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
122092708  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
122071089  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
122084660  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
122059616  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
122059681  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
122067276  S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent), chloroplastic-like [KO:K22846] [EC:2.5.1.144]
122079981  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122068379  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122068815  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122084425  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122074534  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122087626  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
ming00010  Glycolysis / Gluconeogenesis
ming00250  Alanine, aspartate and glutamate metabolism
ming00260  Glycine, serine and threonine metabolism
ming00290  Valine, leucine and isoleucine biosynthesis
ming00430  Taurine and hypotaurine metabolism
ming00480  Glutathione metabolism
ming00620  Pyruvate metabolism
ming00640  Propanoate metabolism
ming00770  Pantothenate and CoA biosynthesis
ming00900  Terpenoid backbone biosynthesis
ming00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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