KEGG   PATHWAY: ming04120
Entry
ming04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Macadamia integrifolia (macadamia nut)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ming04120  Ubiquitin mediated proteolysis
ming04120

Other DBs
GO: 0016567
Organism
Macadamia integrifolia (macadamia nut) [GN:ming]
Gene
122088836  polyubiquitin 8-like [KO:K08770]
122065550  polyubiquitin [KO:K08770]
122068481  polyubiquitin [KO:K08770]
122068483  polyubiquitin-like [KO:K08770]
122087160  polyubiquitin [KO:K08770]
122060448  ubiquitin-60S ribosomal protein L40 [KO:K02927]
122076343  ubiquitin-like [KO:K02927]
122077258  ubiquitin [KO:K02927]
122085943  ubiquitin-60S ribosomal protein L40 [KO:K02927]
122078538  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
122090803  ubiquitin-40S ribosomal protein S27a [KO:K02977]
122057202  ubiquitin-40S ribosomal protein S27a [KO:K02977]
122088087  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
122089400  ubiquitin-activating enzyme E1 2-like isoform X1 [KO:K03178] [EC:6.2.1.45]
122086315  ubiquitin-activating enzyme E1 2-like isoform X1 [KO:K03178] [EC:6.2.1.45]
122080657  SUMO-activating enzyme subunit 1B-1-like isoform X1 [KO:K10684] [EC:6.2.1.45]
122070832  SUMO-activating enzyme subunit 1B-1-like [KO:K10684] [EC:6.2.1.45]
122091778  SUMO-activating enzyme subunit 2-like [KO:K10685] [EC:6.2.1.45]
122074614  SUMO-activating enzyme subunit 2-like isoform X1 [KO:K10685] [EC:6.2.1.45]
122090563  NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
122080719  ubiquitin-conjugating enzyme E2 2-like [KO:K10573] [EC:2.3.2.23]
122084315  ubiquitin-conjugating enzyme E2-17 kDa-like isoform X1 [KO:K10573] [EC:2.3.2.23]
122084316  ubiquitin-conjugating enzyme E2 2-like [KO:K10573] [EC:2.3.2.23]
122085211  ubiquitin-conjugating enzyme E2 2-like [KO:K10573] [EC:2.3.2.23]
122073301  ubiquitin-conjugating enzyme E2 1-like [KO:K10573] [EC:2.3.2.23]
122057951  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
122086500  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
122075094  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
122088585  ubiquitin-conjugating enzyme E2 20-like [KO:K06688] [EC:2.3.2.23]
122063556  ubiquitin-conjugating enzyme E2 20-like [KO:K06688] [EC:2.3.2.23]
122081805  probable ubiquitin-conjugating enzyme E2 C isoform X1 [KO:K06688] [EC:2.3.2.23]
122070474  ubiquitin-conjugating enzyme E2 20-like isoform X1 [KO:K06688] [EC:2.3.2.23]
122057354  probable ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
122086143  ubiquitin-conjugating enzyme E2 20-like [KO:K06688] [EC:2.3.2.23]
122061337  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
122081132  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
122088715  ubiquitin-conjugating enzyme E2 D1-like [KO:K06689] [EC:2.3.2.23]
122089193  ubiquitin-conjugating enzyme E2 11-like [KO:K06689] [EC:2.3.2.23]
122094172  ubiquitin-conjugating enzyme E2 5A-like [KO:K06689] [EC:2.3.2.23]
122069919  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
122059594  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
122073409  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
122059276  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
122070160  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
122087193  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
122057906  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
122061367  constitutive photomorphogenesis protein 10 [KO:K20217] [EC:2.3.2.23]
122091643  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
122066446  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
122070517  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
122087171  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
122060249  ubiquitin-conjugating enzyme E2 5-like isoform X1 [KO:K10576] [EC:2.3.2.23]
122076749  ubiquitin-conjugating enzyme E2-23 kDa-like [KO:K10576] [EC:2.3.2.23]
122088984  ubiquitin-conjugating enzyme E2 4-like [KO:K10576] [EC:2.3.2.23]
122071115  ubiquitin-conjugating enzyme E2-23 kDa-like isoform X1 [KO:K10576] [EC:2.3.2.23]
122072692  ubiquitin-conjugating enzyme E2-23 kDa-like isoform X1 [KO:K10576] [EC:2.3.2.23]
122069468  SUMO-conjugating enzyme SCE1 [KO:K10577]
122071301  SUMO-conjugating enzyme SCE1-like [KO:K10577]
122090581  ubiquitin-conjugating enzyme E2 32-like [KO:K10578] [EC:2.3.2.23]
122085736  ubiquitin-conjugating enzyme E2 32-like [KO:K10578] [EC:2.3.2.23]
122063582  ubiquitin-conjugating enzyme E2 34-like [KO:K04554] [EC:2.3.2.23]
122066709  ubiquitin-conjugating enzyme E2 34-like isoform X1 [KO:K04554] [EC:2.3.2.23]
122067171  ubiquitin-conjugating enzyme E2 34-like [KO:K04554] [EC:2.3.2.23]
122076074  ubiquitin-conjugating enzyme E2 27-like isoform X1 [KO:K04649] [EC:2.3.2.23]
122079021  ubiquitin-conjugating enzyme E2 27-like [KO:K04649] [EC:2.3.2.23]
122080773  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
122087140  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
122078910  ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:2.3.2.23]
122066911  ubiquitin-conjugating enzyme E2 36 [KO:K10580] [EC:2.3.2.23]
122061519  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
122083895  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
122071055  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
122071783  probable ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:2.3.2.24]
122071784  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
122073263  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
122089390  ubiquitin-conjugating enzyme E2 22 [KO:K10583] [EC:2.3.2.23]
122091038  probable ubiquitin-conjugating enzyme E2 18 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
122073889  probable ubiquitin-conjugating enzyme E2 18 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
122085933  E3 ubiquitin-protein ligase UPL7 isoform X1 [KO:K10588] [EC:2.3.2.26]
122062869  E3 ubiquitin-protein ligase UPL6-like isoform X1 [KO:K10589] [EC:2.3.2.26]
122073253  E3 ubiquitin-protein ligase UPL3-like [KO:K10590] [EC:2.3.2.26]
122057747  E3 ubiquitin-protein ligase UPL4 isoform X1 [KO:K10590] [EC:2.3.2.26]
122059543  E3 ubiquitin-protein ligase UPL3-like [KO:K10590] [EC:2.3.2.26]
122073869  E3 ubiquitin-protein ligase UPL2-like isoform X1 [KO:K10592] [EC:2.3.2.26]
122084445  E3 ubiquitin-protein ligase UPL2-like [KO:K10592] [EC:2.3.2.26]
122093328  E3 ubiquitin-protein ligase UPL1-like isoform X1 [KO:K10592] [EC:2.3.2.26]
122059704  E3 ubiquitin-protein ligase UPL1-like [KO:K10592] [EC:2.3.2.26]
122091381  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
122071695  E3 ubiquitin-protein ligase CHIP isoform X1 [KO:K09561] [EC:2.3.2.27]
122086601  peptidyl-prolyl cis-trans isomerase CYP65 [KO:K10598] [EC:5.2.1.8]
122091659  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
122074636  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
122061054  E3 ubiquitin-protein ligase SINAT5 [KO:K04506] [EC:2.3.2.27]
122089301  E3 ubiquitin-protein ligase DIS1-like [KO:K04506] [EC:2.3.2.27]
122089303  E3 ubiquitin-protein ligase SINAT2-like [KO:K04506] [EC:2.3.2.27]
122078525  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
122066221  E3 ubiquitin-protein ligase SINAT2-like [KO:K04506] [EC:2.3.2.27]
122081793  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
122070695  E3 ubiquitin-protein ligase SINAT2-like [KO:K04506] [EC:2.3.2.27]
122075417  E3 ubiquitin-protein ligase SINAT2-like [KO:K04506] [EC:2.3.2.27]
122087299  E3 ubiquitin-protein ligase DIS1 [KO:K04506] [EC:2.3.2.27]
122080714  WD repeat-containing protein RUP2-like [KO:K10143] [EC:2.3.2.27]
122069665  E3 ubiquitin-protein ligase COP1-like [KO:K10143] [EC:2.3.2.27]
122059607  E3 ubiquitin-protein ligase COP1-like [KO:K10143] [EC:2.3.2.27]
122075788  probable E3 ubiquitin-protein ligase RZFP34 isoform X1 [KO:K10144] [EC:2.3.2.27]
122062153  probable E3 ubiquitin-protein ligase RZFP34 isoform X1 [KO:K10144] [EC:2.3.2.27]
122091068  E3 ubiquitin-protein ligase MIEL1-like isoform X1 [KO:K10144] [EC:2.3.2.27]
122082008  E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
122056971  E3 ubiquitin-protein ligase MIEL1-like isoform X1 [KO:K10144] [EC:2.3.2.27]
122075295  E3 ubiquitin-protein ligase RZFP34-like [KO:K10144] [EC:2.3.2.27]
122061506  E4 SUMO-protein ligase PIAL2-like isoform X1 [KO:K04706] [EC:2.3.2.-]
122069659  E4 SUMO-protein ligase PIAL1-like [KO:K04706] [EC:2.3.2.-]
122092714  ERAD-associated E3 ubiquitin-protein ligase HRD1A-like [KO:K10601] [EC:2.3.2.27]
122074469  E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
122076653  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
122083431  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
122090770  cullin-1 isoform X1 [KO:K03347]
122091125  cullin-1-like isoform X1 [KO:K03347]
122058019  cullin-1-like [KO:K03347]
122061103  SKP1-like protein 1A [KO:K03094]
122091592  SKP1-like protein 1A [KO:K03094]
122080642  SKP1-like protein 1A [KO:K03094]
122080717  SKP1-like protein 1A [KO:K03094]
122069264  SKP1-like protein 14 [KO:K03094]
122084411  SKP1-like protein 1B [KO:K03094]
122071936  SKP1-like protein 1A [KO:K03094]
122072092  SKP1-like protein 1B [KO:K03094]
122072704  SKP1-like protein 1A [KO:K03094]
122073705  SKP1-like protein 1B [KO:K03094]
122090525  F-box protein SKP2A-like [KO:K03875]
122093994  F-box protein SKP2B-like [KO:K03875]
122072968  F-box protein SKP2A-like [KO:K03875]
122087620  elongin-C [KO:K03872]
122083630  uncharacterized protein LOC122083630 [KO:K03873]
122076691  cullin-3A-like [KO:K03869]
122079290  cullin-3A-like [KO:K03869]
122080042  cullin-4 [KO:K10609]
122058972  cullin-4 [KO:K10609]
122059210  cullin-4-like [KO:K10609]
122088553  DNA damage-binding protein 1 [KO:K10610]
122058264  protein DAMAGED DNA-BINDING 2 [KO:K10140]
122071137  WD repeat-containing protein ATCSA-1-like isoform X1 [KO:K10570]
122068915  light-mediated development protein DET1 isoform X1 [KO:K10571]
122075672  anaphase-promoting complex subunit 11 [KO:K03358]
122079340  anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
122062907  cell division cycle 20.1, cofactor of APC complex-like [KO:K03363]
122065103  cell division cycle 20.1, cofactor of APC complex-like [KO:K03363]
122082492  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
122082781  cell division cycle 20.1, cofactor of APC complex-like [KO:K03363]
122074088  cell division cycle 20.1, cofactor of APC complex-like [KO:K03363]
122086772  cell division cycle 20.3, cofactor of APC complex-like [KO:K03363]
122087479  cell division cycle 20.5, cofactor of APC complex-like isoform X1 [KO:K03363]
122088205  protein FIZZY-RELATED 3 [KO:K03364]
122064258  protein FIZZY-RELATED 2-like [KO:K03364]
122071140  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
122066387  cell division cycle protein 27 homolog B-like isoform X1 [KO:K03350]
122075372  cell division cycle protein 27 homolog B-like isoform X1 [KO:K03350]
122079526  anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
122076562  anaphase-promoting complex subunit 5 [KO:K03352]
122074030  anaphase-promoting complex subunit 6 [KO:K03353]
122058419  anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
122077457  anaphase-promoting complex subunit 8 [KO:K03355]
122074553  anaphase-promoting complex subunit 10 [KO:K03357]
122093923  anaphase-promoting complex subunit 13 [KO:K12456]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
ming03050  Proteasome
KO pathway
ko04120   
LinkDB

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