KEGG   PATHWAY: mmf04142
Entry
mmf04142                    Pathway                                
Name
Lysosome - Molossus molossus (Pallas's mastiff bat)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
mmf04142  Lysosome
mmf04142

Other DBs
GO: 0005764
Organism
Molossus molossus (Pallas's mastiff bat) [GN:mmf]
Gene
118639820  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
118634591  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
118619825  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
118628164  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
118638493  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
118631601  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
118631521  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
118636215  ATP6AP1; V-type proton ATPase subunit S1 isoform X1 [KO:K03662]
118642810  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
118626328  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
118618221  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
118642557  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
118618135  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
118622012  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
118618615  CTSA; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
118615564  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
118627682  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
118628271  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
118637451  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
118627908  CTSF; cathepsin F [KO:K01373] [EC:3.4.22.41]
118640469  cathepsin G-like [KO:K01319] [EC:3.4.21.20]
118643159  cathepsin G-like [KO:K01319] [EC:3.4.21.20]
118640936  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
118637271  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
118629279  CTSL; LOW QUALITY PROTEIN: cathepsin L1 [KO:K01365] [EC:3.4.22.15]
118629594  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
118629621  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
118615531  CTSO; cathepsin O isoform X1 [KO:K01374] [EC:3.4.22.42]
118637207  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
118637209  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
118637210  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
118627634  CTSW; cathepsin W isoform X1 [KO:K08569] [EC:3.4.22.-]
118618330  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
118638316  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
118640262  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
118616782  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
118636517  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
118633019  GLB1; beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
118634780  GAA; lysosomal alpha-glucosidase isoform X1 [KO:K12316] [EC:3.2.1.20]
118637391  GBA; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
118633460  IDUA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
118624061  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
118634677  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
118639330  GALC; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
118641646  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
118642784  beta-glucuronidase-like isoform X1 [KO:K01195] [EC:3.2.1.31]
118627030  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
118621203  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
118641614  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
118629052  HEXA; beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
118630636  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
118615631  MAN2B1; lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
118621939  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
118632990  HYAL3; hyaluronidase-3 isoform X1 [KO:K01197] [EC:3.2.1.35]
118633150  HYAL1; hyaluronidase-1 isoform X1 [KO:K01197] [EC:3.2.1.35]
118633201  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
118619686  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
118620423  HYAL4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
118641150  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
118641716  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
118633894  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
118639488  GALNS; N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
118623511  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
118635949  IDS; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
118634013  SGSH; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
118632479  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
118626580  DNASE2B; deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
118616200  DNASE2; deoxyribonuclease-2-alpha isoform X1 [KO:K01158] [EC:3.1.22.1]
118627555  ACP2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
118615780  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
118616773  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
118622677  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
118622875  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1 [KO:K01444] [EC:3.5.1.26]
118632664  prosaposin isoform X1 [KO:K12382]
118619896  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
118615529  GM2A; ganglioside GM2 activator [KO:K12383]
118627123  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
118620997  PPT2; lysosomal thioesterase PPT2 [KO:K01074] [EC:3.1.2.22]
118635709  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
118622572  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
118615665  LOW QUALITY PROTEIN: lysosome-associated membrane glycoprotein 1-like [KO:K06528]
118616934  LAMP3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
118635000  CD68; macrosialin isoform X1 [KO:K06501]
118624089  CD63; CD63 antigen [KO:K06497]
118632157  SCARB2; lysosome membrane protein 2 [KO:K12384]
118619045  NPC1; NPC intracellular cholesterol transporter 1 isoform X1 [KO:K12385]
118641083  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
118634849  CTNS; cystinosin isoform X1 [KO:K12386]
118620677  SLC17A5; sialin [KO:K12301]
118625341  SLC11A1; natural resistance-associated macrophage protein 1 isoform X1 [KO:K12347]
118623447  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
118626127  LAPTM5; lysosomal-associated transmembrane protein 5 isoform X1 [KO:K12387]
118637606  LOW QUALITY PROTEIN: lysosomal-associated transmembrane protein 4A-like [KO:K12387]
118630863  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
118631583  LAPTM4B; LOW QUALITY PROTEIN: lysosomal-associated transmembrane protein 4B [KO:K12387]
118629484  ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
118640074  ABCB9; ATP-binding cassette sub-family B member 9 [KO:K05656]
118621615  CD164; sialomucin core protein 24 isoform X1 [KO:K06546]
118615174  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
118637219  SORT1; sortilin isoform X1 [KO:K12388]
118642299  CLN3; battenin [KO:K12389]
118622651  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
118615194  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
118622338  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
118633214  SUMF1; formylglycine-generating enzyme isoform X1 [KO:K13444] [EC:1.8.3.7]
118623581  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239] [EC:2.7.8.17]
118641472  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
118641863  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
118620944  IGF2R; cation-independent mannose-6-phosphate receptor isoform X1 [KO:K06564]
118623587  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
118629565  CLTA; clathrin light chain A isoform X1 [KO:K04644]
118616255  CLTB; clathrin light chain B isoform X1 [KO:K04645]
118635039  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
118632709  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
118638241  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
118639844  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
118643598  AP1M2; AP-1 complex subunit mu-2 [KO:K12393]
118615790  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
118635597  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
118641879  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
118625841  AP1S3; AP-1 complex subunit sigma-3 isoform X1 [KO:K12395]
118643713  AP3D1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
118640863  AP3B2; AP-3 complex subunit beta-2 [KO:K12397]
118641628  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
118622671  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
118632251  AP3M1; AP-3 complex subunit mu-1 isoform X1 [KO:K12398]
118641886  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
118631704  AP-3 complex subunit sigma-1-like isoform X1 [KO:K12399]
118628984  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
118637035  AP4B1; AP-4 complex subunit beta-1 [KO:K12401]
118642209  AP4M1; AP-4 complex subunit mu-1 [KO:K12402]
118639909  AP4S1; AP-4 complex subunit sigma-1 [KO:K12403]
118634720  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
118641705  GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
118623975  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
118615891  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
118641585  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform X1 [KO:K19363]
118642134  LITAFD; LITAF domain-containing protein [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
mmf00511  Other glycan degradation
mmf00531  Glycosaminoglycan degradation
mmf04130  SNARE interactions in vesicular transport
mmf04140  Autophagy - animal
mmf04144  Endocytosis
KO pathway
ko04142   
LinkDB

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