KEGG   PATHWAY: mmyo00260
Entry
mmyo00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Myotis myotis (greater mouse-eared bat)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mmyo00260  Glycine, serine and threonine metabolism
mmyo00260

Module
mmyo_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mmyo00260]
mmyo_M00047  Creatine pathway [PATH:mmyo00260]
mmyo_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mmyo00260]
mmyo_M00555  Betaine biosynthesis, choline => betaine [PATH:mmyo00260]
mmyo_M00621  Glycine cleavage system [PATH:mmyo00260]
mmyo_M00974  Betaine metabolism, animals, betaine => glycine [PATH:mmyo00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Myotis myotis (greater mouse-eared bat) [GN:mmyo]
Gene
118651523  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
118649396  SHMT1; serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]
118661587  AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
118667307  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
118668010  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
118651587  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
118651356  LOW QUALITY PROTEIN: phosphoglycerate mutase 2-like [KO:K01834] [EC:5.4.2.11]
118665857  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
118659183  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
118669904  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
118666381  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
118676662  bisphosphoglycerate mutase-like [KO:K01837] [EC:5.4.2.4 5.4.2.11]
118652694  LOW QUALITY PROTEIN: D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
118672830  PHGDH; D-3-phosphoglycerate dehydrogenase isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
118667434  PSAT1; phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]
118655917  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
118651583  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
118657634  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
118668417  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
118653957  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
118653905  amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
118654668  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
118671461  AOC3; membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
118671462  membrane primary amine oxidase-like isoform X1 [KO:K00276] [EC:1.4.3.21]
118671463  AOC2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
118667537  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]
118668479  AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
118665986  DLD; dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]
118666526  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
118662072  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
118674591  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
118663720  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
118678552  DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
118656733  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
118651290  GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
118658661  GAMT; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]
118667977  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
118656151  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
118656687  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
118656692  DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
118672378  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
118666898  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
118660030  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
118676860  CBS; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
118676998  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
118678403  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
118678570  SDSL; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
118671925  SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mmyo00010  Glycolysis / Gluconeogenesis
mmyo00020  Citrate cycle (TCA cycle)
mmyo00230  Purine metabolism
mmyo00250  Alanine, aspartate and glutamate metabolism
mmyo00270  Cysteine and methionine metabolism
mmyo00290  Valine, leucine and isoleucine biosynthesis
mmyo00330  Arginine and proline metabolism
mmyo00470  D-Amino acid metabolism
mmyo00564  Glycerophospholipid metabolism
mmyo00600  Sphingolipid metabolism
mmyo00620  Pyruvate metabolism
mmyo00630  Glyoxylate and dicarboxylate metabolism
mmyo00640  Propanoate metabolism
mmyo00860  Porphyrin metabolism
mmyo00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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