KEGG   PATHWAY: mmyo04727
Entry
mmyo04727                   Pathway                                
Name
GABAergic synapse - Myotis myotis (greater mouse-eared bat)
Description
Gamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes of receptors: GABAA, GABAB, and GABAC receptors. GABAA and GABAC receptors are ionotropic and mediate fast GABA responses by triggering chloride channel openings, while GABAB receptors are metabotropic and mediate slower GABA responses by activating G-proteins and influencing second messenger systems. GABAA receptors, the major sites for fast inhibitory neurotransmission in the CNS, are regulated by phosphorylation mechanisms, affecting both their functional properties and their cell surface mobility and trafficking. GABA release by the presynaptic terminal is negatively regulated by GABAB autoreceptors, and is cleared from the extracellular space by GABA transporters (GATs) located either on the presynaptic terminal or neighboring glial cells.
Class
Organismal Systems; Nervous system
Pathway map
mmyo04727  GABAergic synapse
mmyo04727

Other DBs
GO: 0051932
Organism
Myotis myotis (greater mouse-eared bat) [GN:mmyo]
Gene
118650357  SLC38A1; sodium-coupled neutral amino acid transporter 1 [KO:K14990]
118649622  SLC38A2; sodium-coupled neutral amino acid transporter 2 isoform X1 [KO:K14207]
118650219  GLS2; glutaminase liver isoform, mitochondrial isoform X1 [KO:K01425] [EC:3.5.1.2]
118661210  GLS; LOW QUALITY PROTEIN: glutaminase kidney isoform, mitochondrial [KO:K01425] [EC:3.5.1.2]
118673688  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
118662227  GAD1; glutamate decarboxylase 1 [KO:K01580] [EC:4.1.1.15]
118663652  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
118656633  ABAT; 4-aminobutyrate aminotransferase, mitochondrial [KO:K13524] [EC:2.6.1.19 2.6.1.22]
118658824  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
118659257  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
118668266  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
118668277  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
118653128  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
118654607  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 isoform X1 [KO:K05175]
118659079  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
118668279  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
118653163  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
118659152  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
118668260  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
118653175  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
118655612  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
118654536  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
118654726  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
118658434  gamma-aminobutyric acid receptor subunit pi [KO:K05189]
118652717  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118675444  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
118662917  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
118671569  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118655815  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118660957  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
118650244  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
118674257  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
118675608  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
118672048  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
118671629  NSF; vesicle-fusing ATPase isoform X1 [KO:K06027] [EC:3.6.4.6]
118661726  TRAK2; trafficking kinesin-binding protein 2 isoform X1 [KO:K15374]
118661895  PLCL1; inactive phospholipase C-like protein 1 [KO:K15375]
118656655  GPHN; gephyrin isoform X1 [KO:K15376] [EC:2.10.1.1 2.7.7.75]
118662782  SLC12A5; solute carrier family 12 member 5 isoform X1 [KO:K23967]
118659699  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
118659701  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190]
118675686  GABRR3; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
118652720  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
118655312  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
118652154  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
118667975  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
118654729  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
118678862  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
118667267  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
118659648  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
118666051  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
118673502  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha isoform X1 [KO:K04630]
118668456  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
118675794  guanine nucleotide-binding protein G(i) subunit alpha-like [KO:K04630]
118674453  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
118655599  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
118655733  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
118649724  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
118676150  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
118651993  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
118655246  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
118648957  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
118678724  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
118666631  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118673940  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118653683  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118661166  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118663367  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118675273  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
118658681  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
118652811  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
118658043  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
118667187  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
118666214  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
118652667  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
118677067  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
118652936  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
118666579  guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548]
118672316  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
118665883  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
118656192  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
118669221  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
118678616  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
118676734  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
118650262  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
118674005  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
118670715  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
118656939  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
118675034  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
118668063  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
118651957  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046]
118668062  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
118651624  SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045]
118673167  GLUL; glutamine synthetase isoform X1 [KO:K01915] [EC:6.3.1.2]
118679352  sodium-coupled neutral amino acid transporter 3-like [KO:K13576]
118668457  SLC38A3; sodium-coupled neutral amino acid transporter 3 [KO:K13576]
118654651  SLC38A5; sodium-coupled neutral amino acid transporter 5 [KO:K14992]
Compound
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00042  Succinate
C00064  L-Glutamine
C00076  Calcium cation
C00238  Potassium cation
C00334  4-Aminobutanoate
C00575  3',5'-Cyclic AMP
C00698  Cl-
Reference
  Authors
Davis KL, Charney D, Coyle JT, Nemeroff C (ed).
  Title
Neuropsychopharmacology: The fifth generation of progress
  Journal
Lippincott Williams & Wikins (2002)
DOI:10.1002/hup.431
Reference
PMID:17499109
  Authors
Farrant M, Kaila K
  Title
The cellular, molecular and ionic basis of GABA(A) receptor signalling.
  Journal
Prog Brain Res 160:59-87 (2007)
DOI:10.1016/S0079-6123(06)60005-8
Reference
PMID:9364667
  Authors
Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL
  Title
GABAA, NMDA and AMPA receptors: a developmentally regulated 'menage a trois'.
  Journal
Trends Neurosci 20:523-9 (1997)
DOI:10.1016/S0166-2236(97)01147-8
Reference
PMID:20655485
  Authors
Pinard A, Seddik R, Bettler B
  Title
GABAB receptors: physiological functions and mechanisms of diversity.
  Journal
Adv Pharmacol 58:231-55 (2010)
DOI:10.1016/S1054-3589(10)58010-4
Reference
PMID:21376567
  Authors
Chalifoux JR, Carter AG
  Title
GABAB receptor modulation of synaptic function.
  Journal
Curr Opin Neurobiol 21:339-44 (2011)
DOI:10.1016/j.conb.2011.02.004
Reference
PMID:20655481
  Authors
Padgett CL, Slesinger PA
  Title
GABAB receptor coupling to G-proteins and ion channels.
  Journal
Adv Pharmacol 58:123-47 (2010)
DOI:10.1016/S1054-3589(10)58006-2
Reference
PMID:17499108
  Authors
Emson PC
  Title
GABA(B) receptors: structure and function.
  Journal
Prog Brain Res 160:43-57 (2007)
DOI:10.1016/S0079-6123(06)60004-6
Reference
PMID:16932937
  Authors
Kornau HC
  Title
GABA(B) receptors and synaptic modulation.
  Journal
Cell Tissue Res 326:517-33 (2006)
DOI:10.1007/s00441-006-0264-7
Reference
PMID:18382465
  Authors
Jacob TC, Moss SJ, Jurd R
  Title
GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition.
  Journal
Nat Rev Neurosci 9:331-43 (2008)
DOI:10.1038/nrn2370
Reference
PMID:12086709
  Authors
Kneussel M
  Title
Dynamic regulation of GABA(A) receptors at synaptic sites.
  Journal
Brain Res Brain Res Rev 39:74-83 (2002)
DOI:10.1016/S0165-0173(02)00159-5
Reference
PMID:21555068
  Authors
Luscher B, Fuchs T, Kilpatrick CL
  Title
GABAA receptor trafficking-mediated plasticity of inhibitory synapses.
  Journal
Neuron 70:385-409 (2011)
DOI:10.1016/j.neuron.2011.03.024
Reference
PMID:19374920
  Authors
Arancibia-Carcamo IL, Kittler JT
  Title
Regulation of GABA(A) receptor membrane trafficking and synaptic localization.
  Journal
Pharmacol Ther 123:17-31 (2009)
DOI:10.1016/j.pharmthera.2009.03.012
Reference
PMID:16787421
  Authors
Bak LK, Schousboe A, Waagepetersen HS
  Title
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer.
  Journal
J Neurochem 98:641-53 (2006)
DOI:10.1111/j.1471-4159.2006.03913.x
Reference
PMID:15210304
  Authors
Conti F, Minelli A, Melone M
  Title
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications.
  Journal
Brain Res Brain Res Rev 45:196-212 (2004)
DOI:10.1016/j.brainresrev.2004.03.003
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:10780899
  Authors
Chebib M, Johnston GA
  Title
GABA-Activated ligand gated ion channels: medicinal chemistry and molecular biology.
  Journal
J Med Chem 43:1427-47 (2000)
DOI:10.1021/jm9904349
Related
pathway
mmyo00020  Citrate cycle (TCA cycle)
mmyo00250  Alanine, aspartate and glutamate metabolism
mmyo04144  Endocytosis
mmyo04721  Synaptic vesicle cycle
KO pathway
ko04727   
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