KEGG   PATHWAY: mna00260
Entry
mna00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Miniopterus natalensis (Natal long-fingered bat)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mna00260  Glycine, serine and threonine metabolism
mna00260

Module
mna_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mna00260]
mna_M00047  Creatine pathway [PATH:mna00260]
mna_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mna00260]
mna_M00555  Betaine biosynthesis, choline => betaine [PATH:mna00260]
mna_M00621  Glycine cleavage system [PATH:mna00260]
mna_M00974  Betaine metabolism, animals, betaine => glycine [PATH:mna00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:mna]
Gene
107524528  SHMT1; serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]
107546144  SHMT2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
107530023  AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
107544991  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
107534800  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
107542651  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
107542068  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
107544342  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
107545345  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107545028  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
107524374  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
107545068  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
107535020  LOW QUALITY PROTEIN: L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
107543146  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
107529153  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
107541450  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
107541464  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
107528920  membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
107528921  AOC2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
107538145  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
107529452  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
107526619  DLD; dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]
107527655  LOW QUALITY PROTEIN: glycine cleavage system H protein, mitochondrial-like [KO:K02437]
107524867  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
107533856  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
107546352  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107535779  GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
107534553  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
107534946  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
107540928  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
107535044  betaine--homocysteine S-methyltransferase 1 isoform X1 [KO:K00544] [EC:2.1.1.5]
107535045  DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
107528762  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
107524617  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
107536922  GNMT; glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]
107541251  CBS; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
107540121  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
107529580  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
107529587  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
107535626  SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mna00010  Glycolysis / Gluconeogenesis
mna00020  Citrate cycle (TCA cycle)
mna00230  Purine metabolism
mna00250  Alanine, aspartate and glutamate metabolism
mna00270  Cysteine and methionine metabolism
mna00290  Valine, leucine and isoleucine biosynthesis
mna00330  Arginine and proline metabolism
mna00470  D-Amino acid metabolism
mna00564  Glycerophospholipid metabolism
mna00600  Sphingolipid metabolism
mna00620  Pyruvate metabolism
mna00630  Glyoxylate and dicarboxylate metabolism
mna00640  Propanoate metabolism
mna00860  Porphyrin metabolism
mna00920  Sulfur metabolism
KO pathway
ko00260   
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