Entry
Name
Longevity regulating pathway - multiple species - Miniopterus natalensis (Natal long-fingered bat)
Description
Aging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, recent work has shown that dietary restriction (DR) and genetic down-regulation of nutrient-sensing pathways, namely IIS (insulin/insulin-like growth factor signalling) and TOR (target-of- rapamycin) can substantially increase healthy life span of laboratory model organisms. These nutrient signaling pathways are conserved in various organisms. In worms, flies, and mammals, DR reduces signalling through IIS/TOR pathways, deactivating the PI3K/Akt/TOR intracellular signalling cascade and consequently activating the antiaging FOXO family transcription factor(s). In yeast, the effects of DR on life- span extension are associated with reduced activities of the TOR/Sch9 and Ras/PKA pathways and require the serine-threonine kinase Rim15 and transcription factors Gis1 and Msn2/4. These transcription factors (FOXO, DAF-16, Gis1, and Msn2/4) transactivate genes involved in resistance to oxidative stress, energy metabolism, DNA damage repair, glucose metabolism, autophagy and protection of proteins by chaperones.
Class
Organismal Systems; Aging
BRITE hierarchy
Pathway map
mna04213 Longevity regulating pathway - multiple species
Ortholog table
Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:
mna ]
Gene
107525521 IRS1; LOW QUALITY PROTEIN: insulin receptor substrate 1 [KO:K16172 ]
107530378 IRS2; LOW QUALITY PROTEIN: insulin receptor substrate 2 [KO:K07187 ]
107532628 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
107538463 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
107541106 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
107526728 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
107529317 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
107535325 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
107543870 PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199 ]
107528511 PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199 ]
107528241 PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200 ]
107524897 PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200 ]
107524851 PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200 ]
107532063 RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
107526023 EIF4EBP2; eukaryotic translation initiation factor 4E-binding protein 2 [KO:K18644 ]
107539014 LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Fontana L, Partridge L, Longo VD
Title
Extending healthy life span--from yeast to humans.
Journal
Reference
Authors
Parrella E, Longo VD
Title
Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain.
Journal
Reference
Authors
Santos J, Leitao-Correia F, Sousa MJ, Leao C
Title
Dietary Restriction and Nutrient Balance in Aging.
Journal
Reference
Authors
Longo VD, Lieber MR, Vijg J
Title
Turning anti-ageing genes against cancer.
Journal
Reference
Authors
Longo VD, Mitteldorf J, Skulachev VP
Title
Programmed and altruistic ageing.
Journal
Reference
Authors
Longo VD, Finch CE
Title
Evolutionary medicine: from dwarf model systems to healthy centenarians?
Journal
Reference
Authors
Mirzaei H, Suarez JA, Longo VD
Title
Protein and amino acid restriction, aging and disease: from yeast to humans.
Journal
Reference
Authors
Kenyon CJ
Title
The genetics of ageing.
Journal
Reference
Authors
Longo VD, Fontana L
Title
Calorie restriction and cancer prevention: metabolic and molecular mechanisms.
Journal
Reference
Authors
Longo VD, Fabrizio P
Title
Chronological aging in Saccharomyces cerevisiae.
Journal
Reference
Authors
Bitto A, Wang AM, Bennett CF, Kaeberlein M
Title
Biochemical Genetic Pathways that Modulate Aging in Multiple Species.
Journal
Reference
Authors
Mair W, Dillin A
Title
Aging and survival: the genetics of life span extension by dietary restriction.
Journal
Reference
Authors
Dali-Youcef N, Lagouge M, Froelich S, Koehl C, Schoonjans K, Auwerx J
Title
Sirtuins: the 'magnificent seven', function, metabolism and longevity.
Journal
Reference
Authors
Rizki G, Iwata TN, Li J, Riedel CG, Picard CL, Jan M, Murphy CT, Lee SS
Title
The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.
Journal
Reference
Authors
Lee SH, Min KJ
Title
Caloric restriction and its mimetics.
Journal
Reference
Authors
Bordone L, Guarente L
Title
Calorie restriction, SIRT1 and metabolism: understanding longevity.
Journal
Reference
Authors
Canto C, Auwerx J
Title
Calorie restriction: is AMPK a key sensor and effector?
Journal
Reference
Authors
Barbieri M, Bonafe M, Franceschi C, Paolisso G
Title
Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans.
Journal
Reference
Authors
Russell SJ, Kahn CR
Title
Endocrine regulation of ageing.
Journal
Related pathway
KO pathway
LinkDB
All DBs