KEGG   PATHWAY: mni00260
Entry
mni00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Macaca nemestrina (pig-tailed macaque)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mni00260  Glycine, serine and threonine metabolism
mni00260

Module
mni_M00047  Creatine pathway [PATH:mni00260]
mni_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mni00260]
mni_M00555  Betaine biosynthesis, choline => betaine [PATH:mni00260]
mni_M00621  Glycine cleavage system [PATH:mni00260]
mni_M00974  Betaine metabolism, animals, betaine => glycine [PATH:mni00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Macaca nemestrina (pig-tailed macaque) [GN:mni]
Gene
105474108  SHMT2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
105491103  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
105473778  AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
105477163  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
105480540  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
105478498  PGAM1; LOW QUALITY PROTEIN: phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
105493775  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
105482977  LOW QUALITY PROTEIN: phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
105494206  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
105471341  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
105479067  PHGDH; D-3-phosphoglycerate dehydrogenase isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
105498720  PSAT1; phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]
105464470  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
105491175  L-threonine 3-dehydrogenase, mitochondrial isoform X1 [KO:K15789] [EC:1.1.1.103]
105480532  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
105493769  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X2 [KO:K00643] [EC:2.3.1.37]
105463379  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
105463385  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
105472087  membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
105472089  membrane primary amine oxidase-like isoform X1 [KO:K00276] [EC:1.4.3.21]
105472092  AOC2; retina-specific copper amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
105489143  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
105480442  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
105475299  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
105495629  glycine cleavage system H protein, mitochondrial [KO:K02437]
105491210  GCSH; LOW QUALITY PROTEIN: glycine cleavage system H protein, mitochondrial [KO:K02437]
105498206  DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
105473059  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
105491008  GATM; glycine amidinotransferase, mitochondrial isoform X2 [KO:K00613] [EC:2.1.4.1]
105486165  GAMT; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]
105480576  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
105463163  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
105468632  alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
105475095  BHMT; LOW QUALITY PROTEIN: betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
105475093  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
105476523  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
105471877  SARDH; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]
105489583  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
105472571  CBS; cystathionine beta-synthase isoform X2 [KO:K01697] [EC:4.2.1.22]
105498368  CTH; cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
105493369  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
105493371  SDS; L-serine dehydratase/L-threonine deaminase isoform X2 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
105471736  SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mni00010  Glycolysis / Gluconeogenesis
mni00020  Citrate cycle (TCA cycle)
mni00230  Purine metabolism
mni00250  Alanine, aspartate and glutamate metabolism
mni00270  Cysteine and methionine metabolism
mni00290  Valine, leucine and isoleucine biosynthesis
mni00330  Arginine and proline metabolism
mni00470  D-Amino acid metabolism
mni00564  Glycerophospholipid metabolism
mni00600  Sphingolipid metabolism
mni00620  Pyruvate metabolism
mni00630  Glyoxylate and dicarboxylate metabolism
mni00640  Propanoate metabolism
mni00860  Porphyrin metabolism
mni00920  Sulfur metabolism
KO pathway
ko00260   
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