KEGG   PATHWAY: morg03013
Entry
morg03013                   Pathway                                
Name
Nucleocytoplasmic transport - Microtus oregoni (creeping vole)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
morg03013  Nucleocytoplasmic transport
morg03013

Other DBs
GO: 0050658
Organism
Microtus oregoni (creeping vole) [GN:morg]
Gene
121459547  aladin [KO:K14320]
121444241  aladin-like [KO:K14320]
121439995  Nup42; nucleoporin NUP42 isoform X1 [KO:K14321]
121463048  Gle1; nucleoporin GLE1 [KO:K18723]
121464807  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
121447044  ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
121447084  ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
121440812  Rae1; mRNA export factor [KO:K14298]
121463655  Nup98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
121462713  Nup214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
121456513  Nup88; nuclear pore complex protein Nup88 [KO:K14318]
121450886  Ranbp2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
121461385  Rangap1; ran GTPase-activating protein 1 [KO:K14319]
121434175  ran GTPase-activating protein 1-like [KO:K14319]
121455860  SUMO-conjugating enzyme UBC9 [KO:K10577]
121463657  Ube2i; SUMO-conjugating enzyme UBC9 [KO:K10577]
121443588  SUMO-conjugating enzyme UBC9-like [KO:K10577]
121441205  SUMO-conjugating enzyme UBC9-like [KO:K10577]
121442003  SUMO-conjugating enzyme UBC9-B-like [KO:K10577]
121442069  SUMO-conjugating enzyme UBC9-like [KO:K10577]
121448699  SUMO-conjugating enzyme UBC9-like [KO:K10577]
121459144  small ubiquitin-related modifier 1 [KO:K12160]
121460260  small ubiquitin-related modifier 2 [KO:K12160]
121436148  Sumo2; small ubiquitin-related modifier 2 [KO:K12160]
121443697  small ubiquitin-related modifier 2-like [KO:K12160]
121450214  small ubiquitin-related modifier 1-like isoform X1 [KO:K12160]
121445147  small ubiquitin-related modifier 1 [KO:K12160]
121448693  small ubiquitin-related modifier 2-like [KO:K12160]
121449277  small ubiquitin-related modifier 3-like [KO:K12160]
121435578  Sumo3; small ubiquitin-related modifier 3 [KO:K12160]
121449518  small ubiquitin-related modifier 2 [KO:K12160]
121435927  small ubiquitin-related modifier 2-like [KO:K12160]
121437631  Nup160; nuclear pore complex protein Nup160 [KO:K14303]
121436280  Nup85; nuclear pore complex protein Nup85 [KO:K14304]
121465485  Sec13; protein SEC13 homolog [KO:K14004]
121459151  Nup107; nuclear pore complex protein Nup107 [KO:K14301]
121447131  Nup133; nuclear pore complex protein Nup133 isoform X1 [KO:K14300]
121466293  Nup43; nucleoporin Nup43 [KO:K14305]
121455829  Nup37; nucleoporin Nup37 isoform X1 [KO:K14302]
121435809  Ahctf1; protein ELYS isoform X1 [KO:K25129]
121448118  Nup62; nuclear pore glycoprotein p62 [KO:K14306]
121434939  Nup58; nucleoporin p58/p45 [KO:K14307]
121460780  Nup54; nucleoporin p54 isoform X1 [KO:K14308]
121463433  Nup205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
121463035  Nup188; nucleoporin NUP188 [KO:K14311]
121432961  Nup155; nuclear pore complex protein Nup155 [KO:K14312]
121447051  Nup93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
121439301  Nup35; nucleoporin NUP35 [KO:K14313]
121448520  Ndc1; nucleoporin NDC1 isoform X1 [KO:K14315]
121450329  Nup210l; nuclear pore membrane glycoprotein 210-like [KO:K14314]
121441563  Nup210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
121445920  Pom121c; nuclear envelope pore membrane protein POM 121C isoform X1 [KO:K14316]
121460720  Tmem33; transmembrane protein 33 isoform X1 [KO:K20724]
121455168  Tpr; nucleoprotein TPR [KO:K09291]
121461169  Nup50; nuclear pore complex protein Nup50 [KO:K14295]
121434164  Nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
121443272  nuclear pore complex protein Nup153-like isoform X1 [KO:K14296]
121464890  Senp2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
121465468  sentrin-specific protease 2-like [KO:K03345] [EC:3.4.22.68]
121452996  sentrin-specific protease 2-like [KO:K03345] [EC:3.4.22.68]
121453003  sentrin-specific protease 2-like [KO:K03345] [EC:3.4.22.68]
121465883  LOW QUALITY PROTEIN: sentrin-specific protease 2-like [KO:K03345] [EC:3.4.22.68]
121461740  Kpna1; importin subunit alpha-5 [KO:K23940]
121465103  Kpna7; importin subunit alpha-8 [KO:K15043]
121436047  Kpna2; importin subunit alpha-1 [KO:K15043]
121443244  importin subunit alpha-1-like [KO:K15043]
121457628  importin subunit alpha-4-like [KO:K23583]
121457940  importin subunit alpha-4 [KO:K23583]
121452709  Kpna4; importin subunit alpha-3 [KO:K23583]
121459088  importin subunit alpha-4-like [KO:K23583]
121459294  importin subunit alpha-4-like [KO:K23583]
121459480  importin subunit alpha-4-like [KO:K23583]
121447987  Kpna6; importin subunit alpha-7 isoform X1 [KO:K15042]
121449420  Kpna5; importin subunit alpha-6 isoform X1 [KO:K15042]
121456282  Kpnb1; importin subunit beta-1 [KO:K14293]
121455636  Tnpo1; transportin-1 [KO:K18752]
121446955  Tnpo2; transportin-2 isoform X1 [KO:K18727]
121463300  Tnpo3; transportin-3 isoform X1 [KO:K15436]
121435130  Ipo4; importin-4 [KO:K20221]
121460936  Ipo5; importin-5 [KO:K20222]
121444440  importin-5-like [KO:K20222]
121439404  LOW QUALITY PROTEIN: importin-5-like [KO:K20222]
121457558  Ipo7; importin-7 [KO:K20223]
121439084  Ipo8; importin-8 isoform X1 [KO:K18755]
121445876  Ipo9; importin-9 isoform X1 [KO:K20224]
121455843  Ipo11; importin-11 isoform X1 [KO:K25201]
121448358  Ipo13; importin-13 [KO:K25202]
121438309  Snupn; snurportin-1 isoform X1 [KO:K13151]
121459532  Xpo1; exportin-1 [KO:K14290]
121460498  Cse1l; exportin-2 [KO:K18423]
121458404  Xpot; exportin-T isoform X1 [KO:K14288]
121435030  Xpo4; exportin-4 isoform X1 [KO:K25203]
121450448  Xpo5; exportin-5 [KO:K14289]
121457598  Xpo6; exportin-6 isoform X1 [KO:K25204]
121458593  Xpo7; exportin-7 isoform X1 [KO:K18460]
121463840  Ranbp17; ran-binding protein 17 isoform X1 [KO:K24115]
121458531  GTP-binding nuclear protein Ran-like [KO:K07936]
121446431  Ran; GTP-binding nuclear protein Ran [KO:K07936]
121449586  GTP-binding nuclear protein Ran-like [KO:K07936]
121456536  elongation factor 1-alpha 1-like [KO:K03231]
121458455  elongation factor 1-alpha 1-like [KO:K03231]
121466154  Eef1a1; elongation factor 1-alpha 1 [KO:K03231]
121466534  elongation factor 1-alpha 1 [KO:K03231]
121444332  elongation factor 1-alpha 1-like [KO:K03231]
121444411  elongation factor 1-alpha 1 [KO:K03231]
121439855  elongation factor 1-alpha 1-like [KO:K03231]
121440530  elongation factor 1-alpha 1-like [KO:K03231]
121440782  Eef1a2; elongation factor 1-alpha 2 [KO:K03231]
121441709  elongation factor 1-alpha 1-like [KO:K03231]
121449153  elongation factor 1-alpha 1-like [KO:K03231]
121449244  elongation factor 1-alpha 1-like [KO:K03231]
121443624  phosphorylated adapter RNA export protein [KO:K14291]
121440689  phosphorylated adapter RNA export protein-like [KO:K14291]
121458280  Ncbp1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
121461772  Ncbp2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
121452819  Nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
121438068  Rbm8a; RNA-binding protein 8A isoform X1 [KO:K12876]
121455413  protein mago nashi homolog [KO:K12877]
121464552  protein mago nashi homolog [KO:K12877]
121440687  Magohb; protein mago nashi homolog 2 isoform X1 [KO:K12877]
121433866  protein mago nashi homolog [KO:K12877]
121448474  Magoh; protein mago nashi homolog [KO:K12877]
121456724  protein CASC3 isoform X1 [KO:K14323]
121442467  Casc3; protein CASC3 isoform X1 [KO:K14323]
121436158  Eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
121448865  eukaryotic initiation factor 4A-III-like [KO:K13025] [EC:5.6.2.7]
121448869  eukaryotic initiation factor 4A-III-like [KO:K13025] [EC:5.6.2.7]
121448870  eukaryotic initiation factor 4A-III-like [KO:K13025] [EC:5.6.2.7]
121435114  Acin1; LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
121435049  Sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
121463934  Rnps1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
121452448  Pnn; pinin [KO:K13114]
121444043  THO complex subunit 4 [KO:K12881]
121444613  THO complex subunit 4 [KO:K12881]
121462601  Upf1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
121432650  Upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
121462109  Upf3a; regulator of nonsense transcripts 3A [KO:K14328]
121444718  regulator of nonsense transcripts 3B-like isoform X1 [KO:K14328]
121441673  regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
121453791  Nxf1; nuclear RNA export factor 1 [KO:K14284]
121436679  Nxf3; nuclear RNA export factor 3 [KO:K14284]
121436681  nuclear RNA export factor 2-like [KO:K14284]
121436732  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
121437104  nuclear RNA export factor 2-like [KO:K14284]
121437107  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
121437240  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
121460264  Nxt1; NTF2-related export protein 1 [KO:K14285]
121436882  Nxt2; NTF2-related export protein 2 [KO:K14285]
121437120  NTF2-related export protein 2-like [KO:K14285]
121462865  spliceosome RNA helicase DDX39B-like [KO:K12812] [EC:5.6.2.7]
121435257  Ddx39b; spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
121447968  Srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
121464576  Pym1; partner of Y14 and mago isoform X1 [KO:K14294]
121453242  THO complex subunit 1 [KO:K12878]
121443337  THO complex subunit 1 [KO:K12878]
121439416  THO complex subunit 2 [KO:K12879]
121440930  THO complex subunit 2-like [KO:K12879]
121459428  THO complex subunit 5 homolog isoform X1 [KO:K13174]
121436459  THO complex subunit 5 homolog isoform X1 [KO:K13174]
121463741  Thoc6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
121454916  Thoc7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
121453113  Thoc3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
morg03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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