KEGG   PATHWAY: mrv00260
Entry
mrv00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Mauremys reevesii (Reeves's turtle)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mrv00260  Glycine, serine and threonine metabolism
mrv00260

Module
mrv_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mrv00260]
mrv_M00047  Creatine pathway [PATH:mrv00260]
mrv_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:mrv00260]
mrv_M00555  Betaine biosynthesis, choline => betaine [PATH:mrv00260]
mrv_M00621  Glycine cleavage system [PATH:mrv00260]
mrv_M00974  Betaine metabolism, animals, betaine => glycine [PATH:mrv00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Mauremys reevesii (Reeves's turtle) [GN:mrv]
Gene
120383840  probable low-specificity L-threonine aldolase 2 isoform X1 [KO:K01620] [EC:4.1.2.48]
120373260  SHMT1; serine hydroxymethyltransferase, cytosolic isoform X1 [KO:K00600] [EC:2.1.2.1]
120390807  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
120372553  AGXT; serine--pyruvate aminotransferase isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
120408683  glyoxylate reductase/hydroxypyruvate reductase-like isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
120408765  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
120369464  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
120398150  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
120409158  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
120380589  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
120370201  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
120408682  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
120387317  PSPH; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
120371597  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
120401736  L-threonine 3-dehydrogenase, mitochondrial-like isoform X1 [KO:K15789] [EC:1.1.1.103]
120388515  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
120369120  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
120395245  amine oxidase [flavin-containing] B-like [KO:K00274] [EC:1.4.3.4]
120389361  amine oxidase [flavin-containing] A-like [KO:K00274] [EC:1.4.3.4]
120392047  AOC3; membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
120392048  membrane primary amine oxidase-like isoform X1 [KO:K00276] [EC:1.4.3.21]
120408426  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
120368808  AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
120392045  DLD; dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]
120384260  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
120386018  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
120407376  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
120373132  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
120391569  GAMT; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]
120409126  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
120408242  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
120408209  betaine--homocysteine S-methyltransferase 1 isoform X1 [KO:K00544] [EC:2.1.1.5]
120408207  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
120387442  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
120386569  SARDH; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]
120400901  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
120405958  cystathionine beta-synthase-like isoform X1 [KO:K01697] [EC:4.2.1.22]
120388810  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
120370486  CTH; cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
120368875  putative threonine dehydratase isoform X1 [KO:K01754] [EC:4.3.1.19]
120385896  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
120385934  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
120387501  SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mrv00010  Glycolysis / Gluconeogenesis
mrv00020  Citrate cycle (TCA cycle)
mrv00230  Purine metabolism
mrv00250  Alanine, aspartate and glutamate metabolism
mrv00270  Cysteine and methionine metabolism
mrv00290  Valine, leucine and isoleucine biosynthesis
mrv00330  Arginine and proline metabolism
mrv00470  D-Amino acid metabolism
mrv00564  Glycerophospholipid metabolism
mrv00600  Sphingolipid metabolism
mrv00620  Pyruvate metabolism
mrv00630  Glyoxylate and dicarboxylate metabolism
mrv00640  Propanoate metabolism
mrv00860  Porphyrin metabolism
mrv00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system