KEGG   PATHWAY: msin00270
Entry
msin00270                   Pathway                                
Name
Cysteine and methionine metabolism - Magnolia sinica
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
msin00270  Cysteine and methionine metabolism
msin00270

Module
msin_M00021  Cysteine biosynthesis, serine => cysteine [PATH:msin00270]
msin_M00034  Methionine salvage pathway [PATH:msin00270]
msin_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:msin00270]
Other DBs
GO: 0006534 0006555
Organism
Magnolia sinica [GN:msin]
Gene
131237044  serine acetyltransferase 2-like [KO:K00640] [EC:2.3.1.30]
131229342  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
131217119  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
131219471  cysteine synthase 2-like [KO:K01738] [EC:2.5.1.47]
131249299  cysteine synthase isoform X1 [KO:K01738] [EC:2.5.1.47]
131249300  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
131240198  cysteine synthase, chloroplastic/chromoplastic-like [KO:K01738] [EC:2.5.1.47]
131240203  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
131231099  bifunctional L-3-cyanoalanine synthase/cysteine synthase 2, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
131234472  cystathionine beta-lyase, chloroplastic isoform X1 [KO:K01760] [EC:4.4.1.13]
131249424  homocysteine S-methyltransferase 2-like isoform X1 [KO:K00547] [EC:2.1.1.10]
131249205  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 2 [KO:K00549] [EC:2.1.1.14]
131233863  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 2-like [KO:K00549] [EC:2.1.1.14]
131233959  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 2 isoform X1 [KO:K00549] [EC:2.1.1.14]
131226273  S-adenosylmethionine synthase 5 [KO:K00789] [EC:2.5.1.6]
131229717  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
131231862  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
131231863  S-adenosylmethionine synthase 5-like [KO:K00789] [EC:2.5.1.6]
131226163  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
131255623  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
131257986  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
131255565  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
131241237  spermine synthase [KO:K00797] [EC:2.5.1.16]
131225701  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
131256115  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
131256116  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
131256331  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
131217155  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
131237349  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase-like [KO:K01244] [EC:3.2.2.16]
131219088  methylthioribose kinase-like isoform X1 [KO:K00899] [EC:2.7.1.100]
131219207  methylthioribose kinase-like isoform X1 [KO:K00899] [EC:2.7.1.100]
131227111  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
131240910  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 1 isoform X1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
131245506  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
131248858  acireductone dioxygenase 2-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
131248861  LOW QUALITY PROTEIN: acireductone dioxygenase 1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
131236431  uncharacterized protein LOC131236431 [KO:K23977] [EC:2.6.1.117]
131241143  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
131245251  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
131245252  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
131245253  probable aminotransferase TAT2 isoform X1 [KO:K00815] [EC:2.6.1.5]
131223318  aromatic aminotransferase ISS1 [KO:K00837] [EC:2.6.1.-]
131233996  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
131247944  DNA (cytosine-5)-methyltransferase CMT2-like isoform X1 [KO:K00558] [EC:2.1.1.37]
131236693  DNA (cytosine-5)-methyltransferase 1B-like [KO:K00558] [EC:2.1.1.37]
131251661  DNA (cytosine-5)-methyltransferase CMT3-like [KO:K00558] [EC:2.1.1.37]
131226279  PWWP domain-containing protein 1-like isoform X1 [KO:K17398] [EC:2.1.1.37]
131231091  PWWP domain-containing protein 1-like [KO:K17398] [EC:2.1.1.37]
131239620  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
131246807  adenosylhomocysteinase 1 [KO:K01251] [EC:3.13.2.1]
131246808  adenosylhomocysteinase 1-like [KO:K01251] [EC:3.13.2.1]
131248822  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
131248823  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
131232322  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
131219455  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
131222844  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
131229043  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
131229673  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
131233764  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
131218258  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
131219606  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
131227220  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
131229259  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
131244396  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
131234795  1-aminocyclopropane-1-carboxylate oxidase 1-like [KO:K05933] [EC:1.14.17.4]
131239314  aspartokinase 1, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
131239318  aspartokinase 2, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
131239322  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
131241418  aspartokinase 2, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
131222710  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
131243477  uncharacterized protein LOC131243477 isoform X1 [KO:K00133] [EC:1.2.1.11]
131225206  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
131257992  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
131257993  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
131217347  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
131217361  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
131233455  cystathionine gamma-synthase 1, chloroplastic [KO:K27857] [EC:2.5.1.160]
131218828  branched-chain-amino-acid aminotransferase 3, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
131228976  branched-chain amino acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
131253532  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
131232429  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
131231953  glutamate--cysteine ligase, chloroplastic isoform X1 [KO:K01919] [EC:6.3.2.2]
131226159  glutathione synthetase, chloroplastic isoform X1 [KO:K21456] [EC:6.3.2.3]
131256952  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
131240976  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
131257016  aspartate aminotransferase, chloroplastic [KO:K00811] [EC:2.6.1.1]
131248917  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
131248320  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
131236982  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
131232994  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
131227966  putative D-cysteine desulfhydrase 1, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
131230204  D-cysteine desulfhydrase 2, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
131225829  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
131245229  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
131240374  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
131233893  malate dehydrogenase-like isoform X1 [KO:K00025] [EC:1.1.1.37]
131245896  malate dehydrogenase, cytoplasmic isoform X1 [KO:K00025] [EC:1.1.1.37]
131218790  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
131250848  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
131250849  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
131228598  malate dehydrogenase, glyoxysomal-like isoform X1 [KO:K00026] [EC:1.1.1.37]
131241065  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
131242074  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
131242075  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
131245341  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
131218597  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
131227402  cysteine synthase [KO:K22846] [EC:2.5.1.144]
131256791  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
131228664  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
131217135  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
131232798  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01102  O-Phospho-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
msin00010  Glycolysis / Gluconeogenesis
msin00250  Alanine, aspartate and glutamate metabolism
msin00260  Glycine, serine and threonine metabolism
msin00290  Valine, leucine and isoleucine biosynthesis
msin00430  Taurine and hypotaurine metabolism
msin00480  Glutathione metabolism
msin00620  Pyruvate metabolism
msin00640  Propanoate metabolism
msin00770  Pantothenate and CoA biosynthesis
msin00900  Terpenoid backbone biosynthesis
msin00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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