KEGG   PATHWAY: msyl00600
Entry
msyl00600                   Pathway                                
Name
Sphingolipid metabolism - Malus sylvestris (European crab apple)
Class
Metabolism; Lipid metabolism
Pathway map
msyl00600  Sphingolipid metabolism
msyl00600

Module
msyl_M00100  Sphingosine degradation [PATH:msyl00600]
Other DBs
GO: 0006665
Organism
Malus sylvestris (European crab apple) [GN:msyl]
Gene
126583067  long chain base biosynthesis protein 2a-like [KO:K00654] [EC:2.3.1.50]
126611517  long chain base biosynthesis protein 2a [KO:K00654] [EC:2.3.1.50]
126633055  long chain base biosynthesis protein 1-like isoform X1 [KO:K00654] [EC:2.3.1.50]
126605470  long chain base biosynthesis protein 1-like isoform X1 [KO:K00654] [EC:2.3.1.50]
126595137  3-dehydrosphinganine reductase TSC10A-like [KO:K04708] [EC:1.1.1.102]
126608602  3-dehydrosphinganine reductase TSC10A-like [KO:K04708] [EC:1.1.1.102]
126614902  neutral ceramidase 1-like [KO:K12349] [EC:3.5.1.23]
126631630  neutral ceramidase 2-like [KO:K12349] [EC:3.5.1.23]
126593051  neutral ceramidase 2-like [KO:K12349] [EC:3.5.1.23]
126586318  alkaline ceramidase-like [KO:K04711] [EC:3.5.1.-]
126623970  alkaline ceramidase [KO:K04711] [EC:3.5.1.-]
126587218  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
126585076  very-long-chain aldehyde decarbonylase GL1-9-like isoform X1 [KO:K04713] [EC:1.14.18.5]
126593032  sphinganine C4-monooxygenase 1-like [KO:K04713] [EC:1.14.18.5]
126607142  sphinganine C4-monooxygenase 1-like [KO:K04713] [EC:1.14.18.5]
126597024  sphinganine C4-monooxygenase 1-like [KO:K04713] [EC:1.14.18.5]
126630279  ceramide kinase isoform X1 [KO:K04715] [EC:2.7.1.138]
126624296  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
126596870  sphingosine-1-phosphate lyase [KO:K01634] [EC:4.1.2.27]
126602605  uncharacterized protein LOC126602605 isoform X1 [KO:K17108] [EC:3.2.1.45]
126618882  uncharacterized protein LOC126618882 isoform X1 [KO:K17108] [EC:3.2.1.45]
126632849  uncharacterized protein LOC126632849 isoform X1 [KO:K17108] [EC:3.2.1.45]
126590359  uncharacterized protein LOC126590359 [KO:K01190] [EC:3.2.1.23]
126634361  beta-galactosidase 17 [KO:K12309] [EC:3.2.1.23]
126627739  alpha-galactosidase 3-like [KO:K07407] [EC:3.2.1.22]
126623073  alpha-galactosidase 3-like [KO:K07407] [EC:3.2.1.22]
126596076  alpha-galactosidase 1-like isoform X1 [KO:K07407] [EC:3.2.1.22]
126609006  alpha-galactosidase 1-like isoform X1 [KO:K07407] [EC:3.2.1.22]
126624830  alpha-galactosidase-like isoform X1 [KO:K07407] [EC:3.2.1.22]
126624831  alpha-galactosidase-like [KO:K07407] [EC:3.2.1.22]
126584514  beta-hexosaminidase 2 [KO:K12373] [EC:3.2.1.52]
126629483  beta-hexosaminidase 1-like [KO:K12373] [EC:3.2.1.52]
126622899  beta-hexosaminidase 1-like [KO:K12373] [EC:3.2.1.52]
126618778  uncharacterized protein LOC126618778 [KO:K12382]
126592820  uncharacterized protein LOC126592820 [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
msyl00260  Glycine, serine and threonine metabolism
msyl00601  Glycosphingolipid biosynthesis - lacto and neolacto series
msyl00603  Glycosphingolipid biosynthesis - globo and isoglobo series
msyl00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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