Entry Name Bacterial invasion of epithelial cells - Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Description Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.
Class Human Diseases; Infectious disease: bacterialBRITE hierarchy
Pathway map nasi05100 Bacterial invasion of epithelial cells
Ortholog table Organism Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) [GN:
nasi ]
Gene 112393757 ARHGAP10; rho GTPase-activating protein 10 isoform X1 [KO:K13736 ]
112404930 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
112400438 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
112414874 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
112402798 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
112403325 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
112406349 PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
112396956 WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753 ]
112414337 WASF2; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 2 [KO:K05748 ]
112411350 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
112393343 BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726 ]
112402693 MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728 ]
112400817 ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
112391748 ELMO3; engulfment and cell motility protein 3 isoform X1 [KO:K19241 ]
Reference Authors Mostowy S, Cossart P
Title Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game.
Journal Reference Authors Hauck CR, Ohlsen K
Title Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.
Journal Reference Authors Wang B, Li S, Dedhar S, Cleary PP
Title Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.
Journal Reference Authors Matsumoto H, Young GM
Title Translocated effectors of Yersinia.
Journal Reference Authors McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title Salmonella takes control: effector-driven manipulation of the host.
Journal Reference Authors Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C
Title A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.
Journal Related KO pathway LinkDB All DBs
