PATHWAY: ko05100 Help
Entry Name Bacterial invasion of epithelial cells
Description Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.
Class Human Diseases; Infectious disease: bacterialBRITE hierarchy
Pathway map ko05100 Bacterial invasion of epithelial cells
Orthology K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K04392 RAC1; Ras-related C3 botulinum toxin substrate 1
K04393 CDC42; cell division control protein 42
K04438 CRK, CRKII; C-crk adapter molecule crk
K04513 RHOA; Ras homolog gene family, member A
K04644 CLTA, LCA; clathrin light chain A
K04645 CLTB, LCB; clathrin light chain B
K04646 CLTC; clathrin heavy chain
K05099 MET, HGFR; proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1 ]
K05689 CDH1, CDHE, CD324; cadherin 1, type 1, E-cadherin
K05692 ACTB_G1; actin beta/gamma 1
K05719 ITGB1, CD29; integrin beta 1
K05726 BCAR1, CAS; breast cancer anti-estrogen resistance 1
K05748 WASF2; WAS protein family, member 2
K05753 WASF1; WAS protein family, member 1
K05754 ARPC5; actin related protein 2/3 complex, subunit 5
K05755 ARPC4; actin related protein 2/3 complex, subunit 4
K05756 ARPC3; actin related protein 2/3 complex, subunit 3
K05757 ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
K05758 ARPC2; actin related protein 2/3 complex, subunit 2
K06279 SHC1; SHC-transforming protein 1
K06484 ITGA5, CD49e; integrin alpha 5
K07863 RHOG; Ras homolog gene family, member G
K09593 GAB1; GRB2-associated-binding protein 1
K12366 ELMO1, CED12; engulfment and cell motility protein 1
K12785 espG, virA; LEE-encoded effector EspG
K13085 ipgD, sopB; phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78 ]
K13285 sipB, ipaB, bipB; invasin B
K13286 sipC, ipaC, bipC; invasin C
K13287 sipD, ipaD, bipD; invasin D
K13708 DOCK1; dedicator of cytokinesis protein 1
K13728 MAD2L2; mitotic spindle assembly checkpoint protein MAD2B
K13732 fnbA; fibronectin-binding protein A
K13733 fnbB; fibronectin-binding protein B
K13734 sfb1; fibronectin-binding protein 1
K13736 ARHGAP10; Rho GTPase-activating protein 10
K13738 CD2AP; CD2-associated protein
K13739 sopD; secreted effector protein SopD
K13740 sptP; secreted effector protein SptP
K13741 sopE; guanine nucleotide exchange factor SopE
K13744 ARHGEF26, SGEF; Rho guanine nucleotide exchange factor 26
K13925 pfbA; plasmin and fibronectin-binding protein A
K16938 SEPT3_9_12; septin 3/9/12
K16939 SEPT6_8_11; septin 6/8/11
K17260 ACTR2, ARP2; actin-related protein 2
K17447 SHC2; SHC-transforming protein 2
K17448 SHC3; SHC-transforming protein 3
K17449 SHC4; SHC-transforming protein 4
K18584 ACTR3, ARP3; actin-related protein 3
K18985 ELMO2, CED12A; engulfment and cell motility protein 2
K19241 ELMO3; engulfment and cell motility protein 3
K23612 WASL; neural Wiskott-Aldrich syndrome protein
Reference Authors Mostowy S, Cossart P
Title Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game.
Journal Reference Authors Hauck CR, Ohlsen K
Title Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.
Journal Reference Authors Wang B, Li S, Dedhar S, Cleary PP
Title Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.
Journal Reference Authors Matsumoto H, Young GM
Title Translocated effectors of Yersinia.
Journal Reference Authors McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title Salmonella takes control: effector-driven manipulation of the host.
Journal Reference Authors Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C
Title A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.
Journal Related ko04810 Regulation of actin cytoskeleton
