KEGG   PATHWAY: ncol04141
Entry
ncol04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Nymphaea colorata (blue-petal water lily)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ncol04141  Protein processing in endoplasmic reticulum
ncol04141

Other DBs
GO: 0030433 0034976
Organism
Nymphaea colorata (blue-petal water lily) [GN:ncol]
Gene
116251679  preprotein translocase subunit SECY, chloroplastic [KO:K10956]
116257524  uncharacterized protein LOC116257524 [KO:K10956]
116258870  uncharacterized protein LOC116258870 [KO:K10956]
116254625  protein transport protein Sec61 subunit beta [KO:K09481]
116267833  protein transport protein Sec61 subunit beta [KO:K09481]
116266080  protein transport protein Sec61 subunit gamma-like [KO:K07342]
116246856  protein transport protein Sec61 subunit gamma [KO:K07342]
116258518  protein transport protein Sec61 subunit gamma-like [KO:K07342]
116259203  protein transport protein Sec61 subunit gamma-like [KO:K07342]
116249289  uncharacterized protein LOC116249289 [KO:K12275]
116261326  dnaJ protein ERDJ2-like [KO:K09540]
116248120  dnaJ protein ERDJ2 [KO:K09540]
116266197  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666]
116248135  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666]
116247599  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
116263904  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
116250173  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
116268404  uncharacterized protein LOC116268404 [KO:K12670]
116256694  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
116249201  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
116247486  probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3B [KO:K19478]
116250936  uncharacterized protein LOC116250936 [KO:K26501]
116266436  uncharacterized protein LOC116266436 [KO:K26502]
116248809  mannosyl-oligosaccharide glucosidase GCS1-like [KO:K01228] [EC:3.2.1.106]
116264173  heat shock 70 kDa protein 17 [KO:K09486]
116252689  luminal-binding protein [KO:K09490] [EC:3.6.4.10]
116255139  dnaJ protein ERDJ3B [KO:K09517]
116254258  dnaJ protein P58IPK homolog B isoform X1 [KO:K09523]
116257995  heat shock protein 90-6, mitochondrial [KO:K09487]
116259346  heat shock protein 90-5, chloroplastic isoform X1 [KO:K09487]
116259828  endoplasmin homolog [KO:K09487]
116266576  probable glucan 1,3-alpha-glucosidase [KO:K05546] [EC:3.2.1.207]
116260437  glucosidase 2 subunit beta isoform X1 [KO:K08288]
116246016  calnexin homolog [KO:K08054]
116247993  calnexin homolog [KO:K08054]
116263198  calreticulin [KO:K08057]
116254162  calreticulin-like [KO:K08057]
116249046  calreticulin-3 [KO:K08057]
116250698  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1-like isoform X1 [KO:K01230] [EC:3.2.1.113]
116247349  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 [KO:K23741] [EC:3.2.1.209]
116247670  SEC12-like protein 1 [KO:K14003]
116258952  SEC12-like protein 2 [KO:K14003]
116251081  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
116262377  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
116263052  GTP-binding protein SAR1A-like [KO:K07953] [EC:3.6.5.-]
116260998  protein transport protein SEC13 homolog B-like [KO:K14004]
116263543  protein transport protein SEC13 homolog B-like [KO:K14004]
116255727  protein transport protein SEC31 homolog B-like [KO:K14005]
116267520  protein transport protein SEC31 homolog B-like isoform X1 [KO:K14005]
116250774  protein transport protein SEC23-like [KO:K14006]
116265680  protein transport protein SEC23 [KO:K14006]
116255706  protein transport protein SEC23 [KO:K14006]
116247652  protein transport protein SEC23-like isoform X1 [KO:K14006]
116256062  protein transport protein Sec24-like At4g32640 isoform X1 [KO:K14007]
116266759  protein transport protein Sec24-like At3g07100 isoform X1 [KO:K14007]
116266952  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
116250116  alpha-mannosidase I MNS5 isoform X2 [KO:K10084]
116256073  alpha-mannosidase I MNS4 isoform X1 [KO:K10085]
116251307  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
116264928  protein disulfide isomerase-like 1-6 [KO:K09580] [EC:5.3.4.1]
116266873  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
116245743  protein disulfide isomerase-like 5-2 [KO:K09580] [EC:5.3.4.1]
116261775  protein disulfide-isomerase like 2-1 [KO:K09584] [EC:5.3.4.1]
116245795  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
116245833  endoplasmic reticulum oxidoreductin-2-like [KO:K10950] [EC:1.8.4.-]
116249938  protein OS-9 homolog [KO:K10088]
116260531  translocon-associated protein subunit alpha-like [KO:K13249]
116247104  translocon-associated protein subunit alpha-like [KO:K13249]
116257097  uncharacterized protein LOC116257097 [KO:K13250]
116249674  uncharacterized protein LOC116249674 [KO:K14009]
116264334  uncharacterized protein LOC116264334 [KO:K14009]
116264764  uncharacterized protein LOC116264764 [KO:K14009]
116256969  uncharacterized protein LOC116256969 isoform X1 [KO:K14009]
116249345  uncharacterized protein LOC116249345 [KO:K14009]
116260976  derlin-1 [KO:K13989]
116264865  derlin-2 [KO:K13989]
116245802  derlin-2.2-like [KO:K13989]
116250796  vicilin-like seed storage protein At2g18540 isoform X1 [KO:K24348]
116260414  plant UBX domain-containing protein 11 isoform X1 [KO:K24348]
116259419  plant UBX domain-containing protein 2 [KO:K14011]
116245282  plant UBX domain-containing protein 4-like [KO:K14012]
116262404  cell division cycle protein 48 homolog [KO:K13525]
116262415  cell division cycle protein 48 homolog [KO:K13525]
116265886  cell division cycle protein 48 homolog isoform X1 [KO:K13525]
116263136  NPL4-like protein 2 [KO:K14015]
116260191  uncharacterized protein LOC116260191 [KO:K14016]
116252780  heat shock cognate 70 kDa protein-like [KO:K03283]
116253389  heat shock cognate 70 kDa protein-like [KO:K03283]
116254282  heat shock cognate 70 kDa protein-like isoform X1 [KO:K03283]
116254350  heat shock 70 kDa protein 3-like [KO:K03283]
116254353  heat shock cognate 70 kDa protein-like [KO:K03283]
116254354  heat shock 70 kDa protein 18-like [KO:K03283]
116255409  heat shock cognate 70 kDa protein 2 [KO:K03283]
116255713  heat shock cognate 70 kDa protein 2-like [KO:K03283]
116257538  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
116265656  dnaJ protein homolog 2-like [KO:K09503]
116265786  dnaJ protein homolog 2-like [KO:K09503]
116266313  dnaJ protein homolog isoform X1 [KO:K09503]
116254180  chaperone protein dnaJ 49-like [KO:K09518]
116268256  chaperone protein dnaJ 49-like [KO:K09518]
116261312  heat shock protein 83-like [KO:K04079]
116248351  heat shock protein 83 [KO:K04079]
116260294  heat shock protein 83-like [KO:K04079]
116253869  hsp70 nucleotide exchange factor fes1-like isoform X1 [KO:K09562]
116256889  hsp70 nucleotide exchange factor fes1-like [KO:K09562]
116248482  uncharacterized protein LOC116248482 isoform X1 [KO:K09562]
116249716  16.9 kDa class I heat shock protein 2-like [KO:K13993]
116249814  small heat shock protein, chloroplastic [KO:K13993]
116260860  22.0 kDa class IV heat shock protein-like [KO:K13993]
116260919  small heat shock protein, chloroplastic [KO:K13993]
116261039  22.0 kDa class IV heat shock protein-like [KO:K13993]
116261565  22.7 kDa class IV heat shock protein-like [KO:K13993]
116262293  class I heat shock protein-like isoform X1 [KO:K13993]
116252175  17.8 kDa class I heat shock protein-like [KO:K13993]
116252209  18.2 kDa class I heat shock protein-like [KO:K13993]
116252644  17.8 kDa class I heat shock protein-like [KO:K13993]
116252645  17.8 kDa class I heat shock protein-like [KO:K13993]
116263632  18.8 kDa class V heat shock protein [KO:K13993]
116263824  17.4 kDa class III heat shock protein-like [KO:K13993]
116264460  17.1 kDa class II heat shock protein-like [KO:K13993]
116264461  17.1 kDa class II heat shock protein-like [KO:K13993]
116264466  17.1 kDa class II heat shock protein-like [KO:K13993]
116264495  17.1 kDa class II heat shock protein-like [KO:K13993]
116264498  17.1 kDa class II heat shock protein-like [KO:K13993]
116264565  22.0 kDa class IV heat shock protein-like [KO:K13993]
116264987  17.1 kDa class II heat shock protein-like [KO:K13993]
116264988  17.1 kDa class II heat shock protein-like [KO:K13993]
116254527  17.8 kDa class I heat shock protein-like [KO:K13993]
116254560  16.9 kDa class I heat shock protein 2-like [KO:K13993]
116254617  small heat shock protein, chloroplastic-like [KO:K13993]
116254982  17.8 kDa class I heat shock protein-like [KO:K13993]
116266235  17.1 kDa class II heat shock protein-like [KO:K13993]
116245048  22.0 kDa class IV heat shock protein [KO:K13993]
116256317  17.8 kDa class I heat shock protein-like [KO:K13993]
116267647  17.8 kDa class I heat shock protein-like [KO:K13993]
116267663  26.5 kDa heat shock protein, mitochondrial [KO:K13993]
116257622  17.8 kDa class I heat shock protein-like [KO:K13993]
116247548  18.1 kDa class I heat shock protein-like [KO:K13993]
116257974  uncharacterized protein LOC116257974 isoform X2 [KO:K13993]
116259572  16.9 kDa class I heat shock protein 1-like [KO:K13993]
116257790  OVARIAN TUMOR DOMAIN-containing deubiquitinating enzyme 2 [KO:K13719] [EC:3.1.2.-]
116252608  uncharacterized protein LOC116252608 [KO:K14018]
116250284  ubiquitin receptor RAD23b-like isoform X1 [KO:K10839]
116250468  ubiquitin receptor RAD23b-like [KO:K10839]
116258873  ubiquitin receptor RAD23c-like [KO:K10839]
116258875  ubiquitin receptor RAD23d-like isoform X1 [KO:K10839]
116260559  ubiquitin domain-containing protein DSK2a-like [KO:K04523]
116248296  ubiquitin domain-containing protein DSK2a-like isoform X1 [KO:K04523]
116264124  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
116254576  ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
116257386  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
116267901  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
116254050  subtilisin-like protease SBT6.1 [KO:K08653] [EC:3.4.21.112]
116260490  membrane-bound transcription factor site-2 protease homolog isoform X1 [KO:K07765] [EC:3.4.24.85]
116260844  serine/threonine-protein kinase/endoribonuclease IRE1b isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
116247932  serine/threonine-protein kinase/endoribonuclease IRE1b-like isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
116268183  LOW QUALITY PROTEIN: uncharacterized protein LOC116268183 [KO:K04440] [EC:2.7.11.24]
116250128  probable E3 ubiquitin ligase SUD1 [KO:K10661] [EC:2.3.2.27]
116255304  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
116257589  ubiquitin-conjugating enzyme E2 34-like [KO:K04554] [EC:2.3.2.23]
116254288  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
116256425  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
116261188  ERAD-associated E3 ubiquitin-protein ligase HRD1B-like [KO:K10601] [EC:2.3.2.27]
116259436  uncharacterized protein LOC116259436 [KO:K10666] [EC:2.3.2.27]
116252581  E3 ubiquitin-protein ligase RMA1-like [KO:K10666] [EC:2.3.2.27]
116249759  uncharacterized protein LOC116249759 [KO:K10666] [EC:2.3.2.27]
116262905  ERAD-associated E3 ubiquitin-protein ligase component HRD3A-like [KO:K14026]
116266013  E3 ubiquitin protein ligase RIN2-like isoform X1 [KO:K10636] [EC:2.3.2.36]
116257495  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
116266865  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
116249001  ubiquitin-conjugating enzyme E2 8-like [KO:K06689] [EC:2.3.2.23]
116250302  ubiquitin-conjugating enzyme E2 5A [KO:K06689] [EC:2.3.2.23]
116262549  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
116244920  ubiquitin-conjugating enzyme E2-16 kDa [KO:K06689] [EC:2.3.2.23]
116258741  ubiquitin-conjugating enzyme E2 5A-like [KO:K06689] [EC:2.3.2.23]
116251544  SUMO-conjugating enzyme UBC9-like [KO:K06689] [EC:2.3.2.23]
116249240  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
116260775  SUMO-conjugating enzyme UBC9-like [KO:K06689] [EC:2.3.2.23]
116262547  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
116262899  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
116259708  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
116262373  cullin-1 [KO:K03347]
116254247  cullin-1-like [KO:K03347]
116260543  SKP1-like protein 1A [KO:K03094]
116252942  SKP1-like protein 1A [KO:K03094]
116256503  SKP1-like protein 1A [KO:K03094]
116247722  SKP1-like protein 1A [KO:K03094]
116247723  SKP1-like protein 1A [KO:K03094]
116247862  SKP1-like protein 1A [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
ncol00510  N-Glycan biosynthesis
ncol03050  Proteasome
ncol03060  Protein export
KO pathway
ko04141   
LinkDB

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