KEGG   PATHWAY: npo00260
Entry
npo00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Nyctereutes procyonoides (raccoon dog)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
npo00260  Glycine, serine and threonine metabolism
npo00260

Module
npo_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:npo00260]
npo_M00047  Creatine pathway [PATH:npo00260]
npo_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:npo00260]
npo_M00555  Betaine biosynthesis, choline => betaine [PATH:npo00260]
npo_M00621  Glycine cleavage system [PATH:npo00260]
npo_M00974  Betaine metabolism, animals, betaine => glycine [PATH:npo00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Nyctereutes procyonoides (raccoon dog) [GN:npo]
Gene
129503220  uncharacterized protein LOC129503220 isoform X1 [KO:K01620] [EC:4.1.2.48]
129497261  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
129511551  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
129493816  AGXT; alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
129495104  GRHPR; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
129521472  GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]
129515966  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
129523329  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
129516217  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
129501333  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
129501355  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
129501385  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
129500872  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
129519539  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
129511944  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
129493612  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
129518685  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
129522063  ALAS1; 5-aminolevulinate synthase, non-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
129518550  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
129518630  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
129512067  membrane primary amine oxidase-like isoform X1 [KO:K00276] [EC:1.4.3.21]
129512088  membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
129512307  AOC2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
129494814  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
129504828  LOW QUALITY PROTEIN: aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]
129521351  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
129494364  DLD; dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]
129497771  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
129507760  DAO; D-amino-acid oxidase isoform X1 [KO:K00273] [EC:1.4.3.3]
129509877  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
129504247  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
129521660  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
129521342  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
129495124  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
129521084  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
129521083  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
129517528  PIPOX; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
129505342  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
129512905  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
129502140  CBS; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
129519590  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
129508011  SDS; L-serine dehydratase/L-threonine deaminase isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
129508336  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
129509619  SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
npo00010  Glycolysis / Gluconeogenesis
npo00020  Citrate cycle (TCA cycle)
npo00230  Purine metabolism
npo00250  Alanine, aspartate and glutamate metabolism
npo00270  Cysteine and methionine metabolism
npo00290  Valine, leucine and isoleucine biosynthesis
npo00330  Arginine and proline metabolism
npo00470  D-Amino acid metabolism
npo00564  Glycerophospholipid metabolism
npo00600  Sphingolipid metabolism
npo00620  Pyruvate metabolism
npo00630  Glyoxylate and dicarboxylate metabolism
npo00640  Propanoate metabolism
npo00860  Porphyrin metabolism
npo00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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