KEGG   PATHWAY: npr03083
Entry
npr03083                    Pathway                                
Name
Polycomb repressive complex - Nanorana parkeri (Xizang Plateau frog)
Class
Genetic Information Processing; Chromosome
Pathway map
npr03083  Polycomb repressive complex
npr03083

Organism
Nanorana parkeri (Xizang Plateau frog) [GN:npr]
Gene
108796324  EZH1; histone-lysine N-methyltransferase EZH1 isoform X1 [KO:K17451] [EC:2.1.1.356]
108794364  EZH2; histone-lysine N-methyltransferase EZH2 [KO:K11430] [EC:2.1.1.356]
108784427  EED; polycomb protein EED isoform X1 [KO:K11462]
108802983  SUZ12; polycomb protein SUZ12 isoform X1 [KO:K11463]
108795332  RBBP4; histone-binding protein RBBP4 isoform X1 [KO:K10752]
108791272  RBBP7; histone-binding protein RBBP7 isoform X1 [KO:K11659]
108788385  PHF1; PHD finger protein 1 [KO:K11467]
108789247  MTF2; metal-response element-binding transcription factor 2 [KO:K11485]
108793650  PHF19; PHD finger protein 19 [KO:K11486]
108794655  LCOR; ligand-dependent corepressor [KO:K26260]
108791828  AEBP2; zinc finger protein AEBP2 isoform X1 [KO:K17452]
108793769  JARID2; protein Jumonji [KO:K11478]
108793423  BAP1; ubiquitin carboxyl-terminal hydrolase BAP1 [KO:K08588] [EC:3.4.19.12]
108802867  ASXL2; LOW QUALITY PROTEIN: putative Polycomb group protein ASXL2 [KO:K11471]
108786098  ASXL3; putative Polycomb group protein ASXL3 [KO:K11471]
108786953  ASXL1; putative Polycomb group protein ASXL1 [KO:K11471]
108802573  OGT; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit [KO:K09667] [EC:2.4.1.255]
108790459  HCFC1; host cell factor 1 [KO:K14966]
108801752  YY1; transcriptional repressor protein YY1 [KO:K09201]
108795506  MBD5; methyl-CpG-binding domain protein 5 [KO:K23219]
108797853  MBD6; methyl-CpG-binding domain protein 6 [KO:K26585]
108795519  FOXK1; forkhead box protein K1 [KO:K09404]
108795281  FOXK2; forkhead box protein K2 [KO:K09404]
108796435  E3 ubiquitin-protein ligase RING2-like [KO:K10695] [EC:2.3.2.27]
108788378  RING1; E3 ubiquitin-protein ligase RING1 [KO:K10695] [EC:2.3.2.27]
108784208  E3 ubiquitin-protein ligase RING2 [KO:K10695] [EC:2.3.2.27]
108789989  PCGF2; polycomb group RING finger protein 2 [KO:K11460]
108793036  polycomb complex protein BMI-1 [KO:K11459]
108796858  chromobox protein homolog 2-like [KO:K11451]
108792974  CBX4; E3 SUMO-protein ligase CBX4 [KO:K11452] [EC:2.3.2.-]
108798503  CBX6; chromobox protein homolog 6 [KO:K11453]
108798504  CBX7; chromobox protein homolog 7 [KO:K11454]
108792975  CBX8; chromobox protein homolog 8 [KO:K11455]
108799451  PHC1; polyhomeotic-like protein 1 isoform X1 [KO:K11456]
108802716  polyhomeotic-like protein 2 [KO:K11457]
108784830  PHC3; polyhomeotic-like protein 3 [KO:K11458]
108791278  SCML2; sex comb on midleg-like protein 2 [KO:K11465]
108786648  SCMH1; polycomb protein SCMH1 [KO:K11461]
108795257  SFMBT2; scm-like with four MBT domains protein 2 [KO:K26269]
108793785  AURKB; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
108792479  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
108788865  UBE2D1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
108789058  UBE2D3; ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
108793956  USP45; ubiquitin carboxyl-terminal hydrolase 45 [KO:K11844] [EC:3.4.19.12]
108786141  USP16; ubiquitin carboxyl-terminal hydrolase 16 isoform X1 [KO:K11844] [EC:3.4.19.12]
108792280  RYBP; RING1 and YY1-binding protein [KO:K11469]
108783847  YAF2; YY1-associated factor 2 [KO:K11468]
108801104  KDM2A; lysine-specific demethylase 2A [KO:K10276] [EC:1.14.11.27]
108787819  KDM2B; lysine-specific demethylase 2B isoform X1 [KO:K10276] [EC:1.14.11.27]
108786928  BCOR; BCL-6 corepressor isoform X1 [KO:K23215]
108804498  BCORL1; BCL-6 corepressor-like protein 1 [KO:K26199]
108792127  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
108798125  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
108796651  PCGF3; polycomb group RING finger protein 3 [KO:K11488]
108792142  PCGF5; polycomb group RING finger protein 5 [KO:K11489]
108793757  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
108788148  AUTS2; autism susceptibility gene 2 protein [KO:K23214]
108787919  FBRSL1; fibrosin-1-like protein isoform X1 [KO:K26254]
108785977  DCAF7; DDB1- and CUL4-associated factor 7 isoform X1 [KO:K11805]
108800720  TEX10; testis-expressed sequence 10 protein [KO:K14827]
108793027  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
108791110  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
108784565  PCGF6; polycomb group RING finger protein 6 [KO:K11470]
108788594  E2F6; transcription factor E2F6 [KO:K09390]
108791691  TFDP1; transcription factor Dp-1 [KO:K04683]
108801671  MAX; protein max isoform X1 [KO:K04453]
108789909  MGA; MAX gene-associated protein [KO:K23399]
108792956  lethal(3)malignant brain tumor-like protein 3 isoform X1 [KO:K24387]
108791969  L3MBTL1; lethal(3)malignant brain tumor-like protein 1 [KO:K24387]
108804442  CBX3; chromobox protein homolog 3 isoform X1 [KO:K11586]
108795635  WDR5; WD repeat-containing protein 5 [KO:K14963]
108795331  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
108789383  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
Reference
PMID:21881606
  Authors
Richly H, Aloia L, Di Croce L
  Title
Roles of the Polycomb group proteins in stem cells and cancer.
  Journal
Cell Death Dis 2:e204 (2011)
DOI:10.1038/cddis.2011.84
Reference
PMID:28202673
  Authors
Chittock EC, Latwiel S, Miller TC, Muller CW
  Title
Molecular architecture of polycomb repressive complexes.
  Journal
Biochem Soc Trans 45:193-205 (2017)
DOI:10.1042/BST20160173
Reference
PMID:33202645
  Authors
Geng Z, Gao Z
  Title
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms.
  Journal
Int J Mol Sci 21:ijms21228594 (2020)
DOI:10.3390/ijms21228594
Reference
PMID:35681061
  Authors
Kim JJ, Kingston RE
  Title
Context-specific Polycomb mechanisms in development.
  Journal
Nat Rev Genet 23:680-695 (2022)
DOI:10.1038/s41576-022-00499-0
Reference
PMID:36076977
  Authors
Dong GJ, Xu JL, Qi YR, Yuan ZQ, Zhao W
  Title
Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer.
  Journal
Int J Mol Sci 23:ijms23179574 (2022)
DOI:10.3390/ijms23179574
Reference
PMID:37086328
  Authors
Ryan CW, Peirent ER, Regan SL, Guxholli A, Bielas SL
  Title
H2A monoubiquitination: insights from human genetics and animal models.
  Journal
Hum Genet 10.1007/s00439-023-02557-x (2023)
DOI:10.1007/s00439-023-02557-x
KO pathway
ko03083   
LinkDB

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