KEGG   PATHWAY: nss03083
Entry
nss03083                    Pathway                                
Name
Polycomb repressive complex - Notechis scutatus (mainland tiger snake)
Class
Genetic Information Processing; Chromosome
Pathway map
nss03083  Polycomb repressive complex
nss03083

Organism
Notechis scutatus (mainland tiger snake) [GN:nss]
Gene
113420059  EZH1; histone-lysine N-methyltransferase EZH1 isoform X1 [KO:K17451] [EC:2.1.1.356]
113421522  EZH2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
113420532  EED; polycomb protein EED [KO:K11462]
113420729  SUZ12; polycomb protein SUZ12 [KO:K11463]
113416058  RBBP4; histone-binding protein RBBP4 isoform X1 [KO:K10752]
113414775  MTF2; metal-response element-binding transcription factor 2 isoform X1 [KO:K11485]
113424791  PHF19; PHD finger protein 19 isoform X1 [KO:K11486]
113413506  EPOP; elongin BC and Polycomb repressive complex 2-associated protein isoform X1 [KO:K26259]
113415060  LCOR; ligand-dependent corepressor isoform X1 [KO:K26260]
113419030  AEBP2; zinc finger protein AEBP2 [KO:K17452]
113413609  JARID2; protein Jumonji [KO:K11478]
113415723  BAP1; ubiquitin carboxyl-terminal hydrolase BAP1 [KO:K08588] [EC:3.4.19.12]
113414599  ASXL2; putative Polycomb group protein ASXL2 isoform X1 [KO:K11471]
113413780  ASXL3; putative Polycomb group protein ASXL3 [KO:K11471]
113423064  OGT; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [KO:K09667] [EC:2.4.1.255]
113417696  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
113420352  YY1; transcriptional repressor protein YY1 isoform X1 [KO:K09201]
113415904  MBD5; methyl-CpG-binding domain protein 5 isoform X1 [KO:K23219]
113416175  MBD6; methyl-CpG-binding domain protein 6 isoform X1 [KO:K26585]
113427002  FOXK1; forkhead box protein K1 [KO:K09404]
113418211  FOXK2; forkhead box protein K2 isoform X1 [KO:K09404]
113413186  RNF2; E3 ubiquitin-protein ligase RING2 [KO:K10695] [EC:2.3.2.27]
113424425  PCGF2; polycomb group RING finger protein 2 isoform X1 [KO:K11460]
113427310  polycomb complex protein BMI-1-like isoform X1 [KO:K11459]
113417353  BMI1; polycomb complex protein BMI-1 isoform X1 [KO:K11459]
113411966  chromobox protein homolog 2-like [KO:K11451]
113411964  CBX4; E3 SUMO-protein ligase CBX4 [KO:K11452] [EC:2.3.2.-]
113432718  CBX6; chromobox protein homolog 6 isoform X1 [KO:K11453]
113432720  CBX7; chromobox protein homolog 7 [KO:K11454]
113411965  CBX8; chromobox protein homolog 8 [KO:K11455]
113417225  PHC1; LOW QUALITY PROTEIN: polyhomeotic-like protein 1 [KO:K11456]
113429533  polyhomeotic-like protein 2 [KO:K11457]
113411224  PHC3; polyhomeotic-like protein 3 isoform X1 [KO:K11458]
113416846  SCML2; sex comb on midleg-like protein 2 [KO:K11465]
113419858  SCMH1; polycomb protein SCMH1 isoform X1 [KO:K11461]
113420560  SFMBT1; scm-like with four MBT domains protein 1 [KO:K26269]
113422829  SFMBT2; scm-like with four MBT domains protein 2 [KO:K26269]
113410492  aurora kinase C-like [KO:K11479] [EC:2.7.11.1]
113427319  aurora kinase C-like [KO:K11479] [EC:2.7.11.1]
113425062  UBE2D1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
113415252  UBE2D2; ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
113415348  UBE2D3; ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
113409860  USP16; ubiquitin carboxyl-terminal hydrolase 16 [KO:K11844] [EC:3.4.19.12]
113411506  ubiquitin carboxyl-terminal hydrolase 45-like [KO:K11844] [EC:3.4.19.12]
113419590  RYBP; RING1 and YY1-binding protein [KO:K11469]
113413089  YAF2; YY1-associated factor 2 [KO:K11468]
113417912  PCGF1; polycomb group RING finger protein 1 [KO:K11487]
113424750  KDM2A; lysine-specific demethylase 2A isoform X1 [KO:K10276] [EC:1.14.11.27]
113424924  KDM2B; lysine-specific demethylase 2B [KO:K10276] [EC:1.14.11.27]
113416280  BCOR; BCL-6 corepressor isoform X1 [KO:K23215]
113416681  BCORL1; BCL-6 corepressor-like protein 1 [KO:K26199]
113425249  SKP1; S-phase kinase-associated protein 1 isoform X1 [KO:K03094]
113424216  USP7; ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
113415523  PCGF3; polycomb group RING finger protein 3 isoform X1 [KO:K11488]
113414065  PCGF5; polycomb group RING finger protein 5 isoform X1 [KO:K11489]
113424596  CSNK2B; casein kinase II subunit beta [KO:K03115]
113415114  AUTS2; autism susceptibility gene 2 protein [KO:K23214]
113421725  FBRS; probable fibrosin-1 isoform X1 [KO:K26253]
113423500  FBRSL1; fibrosin-1-like protein isoform X1 [KO:K26254]
113420073  DCAF7; DDB1- and CUL4-associated factor 7 [KO:K11805]
113419100  TEX10; testis-expressed protein 10 isoform X1 [KO:K14827]
113422398  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
113432691  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
113411053  PCGF6; polycomb group RING finger protein 6 [KO:K11470]
113416438  E2F6; transcription factor E2F6 [KO:K09390]
113411600  TFDP1; transcription factor Dp-1 [KO:K04683]
113410860  MAX; protein max isoform X1 [KO:K04453]
113410152  MGA; MAX gene-associated protein isoform X1 [KO:K23399]
113411171  L3MBTL3; lethal(3)malignant brain tumor-like protein 3 [KO:K24387]
113421837  L3MBTL1; lethal(3)malignant brain tumor-like protein 1 [KO:K24387]
113417636  lethal(3)malignant brain tumor-like protein 4 [KO:K24387]
113432692  L3MBTL2; lethal(3)malignant brain tumor-like protein 2 isoform X1 [KO:K24387]
113415979  CBX3; chromobox protein homolog 3 [KO:K11586]
113426912  WDR5; WD repeat-containing protein 5 [KO:K14963]
113416044  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
113411561  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
Reference
PMID:21881606
  Authors
Richly H, Aloia L, Di Croce L
  Title
Roles of the Polycomb group proteins in stem cells and cancer.
  Journal
Cell Death Dis 2:e204 (2011)
DOI:10.1038/cddis.2011.84
Reference
PMID:28202673
  Authors
Chittock EC, Latwiel S, Miller TC, Muller CW
  Title
Molecular architecture of polycomb repressive complexes.
  Journal
Biochem Soc Trans 45:193-205 (2017)
DOI:10.1042/BST20160173
Reference
PMID:33202645
  Authors
Geng Z, Gao Z
  Title
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms.
  Journal
Int J Mol Sci 21:ijms21228594 (2020)
DOI:10.3390/ijms21228594
Reference
PMID:35681061
  Authors
Kim JJ, Kingston RE
  Title
Context-specific Polycomb mechanisms in development.
  Journal
Nat Rev Genet 23:680-695 (2022)
DOI:10.1038/s41576-022-00499-0
Reference
PMID:36076977
  Authors
Dong GJ, Xu JL, Qi YR, Yuan ZQ, Zhao W
  Title
Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer.
  Journal
Int J Mol Sci 23:ijms23179574 (2022)
DOI:10.3390/ijms23179574
Reference
PMID:37086328
  Authors
Ryan CW, Peirent ER, Regan SL, Guxholli A, Bielas SL
  Title
H2A monoubiquitination: insights from human genetics and animal models.
  Journal
Hum Genet 10.1007/s00439-023-02557-x (2023)
DOI:10.1007/s00439-023-02557-x
KO pathway
ko03083   
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