KEGG   PATHWAY: nvs00260
Entry
nvs00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Neogale vison (American mink)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
nvs00260  Glycine, serine and threonine metabolism
nvs00260

Module
nvs_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:nvs00260]
nvs_M00047  Creatine pathway [PATH:nvs00260]
nvs_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:nvs00260]
nvs_M00555  Betaine biosynthesis, choline => betaine [PATH:nvs00260]
nvs_M00621  Glycine cleavage system [PATH:nvs00260]
nvs_M00974  Betaine metabolism, animals, betaine => glycine [PATH:nvs00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Neogale vison (American mink) [GN:nvs]
Gene
122905935  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
122891481  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
122906871  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
122901800  AGXT; serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
122917456  GRHPR; glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
122909362  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
122904680  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
122900978  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
122905090  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
122900393  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122917672  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
122895315  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
122891955  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
122889700  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
122897661  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
122909366  ALAS1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
122896959  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
122897259  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
122906170  membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
122906172  AOC2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
122907592  membrane primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
122917610  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
122909428  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
122904696  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
122911206  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
122903331  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
122895443  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122893382  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
122910830  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
122909339  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
122916525  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
122901114  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
122918260  DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
122906394  PIPOX; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
122917099  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
122908333  GNMT; glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]
122908265  CBS; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
122900085  CTH; cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
122903397  SDSL; serine dehydratase-like isoform X1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
122903398  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
122906334  SRR; serine racemase [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
nvs00010  Glycolysis / Gluconeogenesis
nvs00020  Citrate cycle (TCA cycle)
nvs00230  Purine metabolism
nvs00250  Alanine, aspartate and glutamate metabolism
nvs00270  Cysteine and methionine metabolism
nvs00290  Valine, leucine and isoleucine biosynthesis
nvs00330  Arginine and proline metabolism
nvs00470  D-Amino acid metabolism
nvs00564  Glycerophospholipid metabolism
nvs00600  Sphingolipid metabolism
nvs00620  Pyruvate metabolism
nvs00630  Glyoxylate and dicarboxylate metabolism
nvs00640  Propanoate metabolism
nvs00860  Porphyrin metabolism
nvs00920  Sulfur metabolism
KO pathway
ko00260   
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