KEGG   PATHWAY: obr00270
Entry
obr00270                    Pathway                                
Name
Cysteine and methionine metabolism - Oryza brachyantha (malo sina)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
obr00270  Cysteine and methionine metabolism
obr00270

Module
obr_M00021  Cysteine biosynthesis, serine => cysteine [PATH:obr00270]
obr_M00034  Methionine salvage pathway [PATH:obr00270]
obr_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:obr00270]
Other DBs
GO: 0006534 0006555
Organism
Oryza brachyantha (malo sina) [GN:obr]
Gene
102717386  probable serine acetyltransferase 1 [KO:K00640] [EC:2.3.1.30]
102700123  probable serine acetyltransferase 1 [KO:K00640] [EC:2.3.1.30]
102715928  probable serine acetyltransferase 4 [KO:K00640] [EC:2.3.1.30]
102709468  probable serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
102711134  probable serine acetyltransferase 2 [KO:K00640] [EC:2.3.1.30]
102720578  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
102716388  cysteine synthase [KO:K01738] [EC:2.5.1.47]
102716876  cysteine synthase isoform X1 [KO:K01738] [EC:2.5.1.47]
102704408  cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
102720436  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
102699315  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
102704342  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
102707174  cysteine synthase [KO:K01738] [EC:2.5.1.47]
102715851  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
102719963  cystathionine beta-lyase, chloroplastic [KO:K01760] [EC:4.4.1.13]
102715708  homocysteine S-methyltransferase 4-like [KO:K00547] [EC:2.1.1.10]
102705053  homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
102720634  homocysteine S-methyltransferase 2-like [KO:K00547] [EC:2.1.1.10]
102718131  homocysteine S-methyltransferase 3 [KO:K00547] [EC:2.1.1.10]
102700509  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1 [KO:K00549] [EC:2.1.1.14]
102706616  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1 [KO:K00549] [EC:2.1.1.14]
102713783  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
102706694  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
102709077  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
102704030  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
102718357  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
102718203  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
102712605  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
102700437  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
102711895  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
102707806  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
102702270  nicotianamine synthase 2 [KO:K05953] [EC:2.5.1.43]
102699669  nicotianamine synthase 1 [KO:K05953] [EC:2.5.1.43]
102715132  nicotianamine synthase 3 [KO:K05953] [EC:2.5.1.43]
121055712  nicotianamine synthase 2-like [KO:K05953] [EC:2.5.1.43]
102702761  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase-like [KO:K01244] [EC:3.2.2.16]
102708989  methylthioribose kinase 1 [KO:K00899] [EC:2.7.1.100]
102699995  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
102715061  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
102701760  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K09880] [EC:3.1.3.77]
102715462  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
102719799  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 4 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
102719518  heat stress transcription factor A-2c [KO:K08967] [EC:1.13.11.53 1.13.11.54]
102709592  probable N-succinyldiaminopimelate aminotransferase DapC [KO:K23977] [EC:2.6.1.117]
102714105  nicotianamine aminotransferase 1-like isoform X1 [KO:K00815] [EC:2.6.1.5]
102717663  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
102710536  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
102721243  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
102713125  aromatic aminotransferase ISS1 isoform X1 [KO:K00837] [EC:2.6.1.-]
102715888  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
102705535  DNA (cytosine-5)-methyltransferase CMT2-like [KO:K00558] [EC:2.1.1.37]
102713176  DNA (cytosine-5)-methyltransferase 1A [KO:K00558] [EC:2.1.1.37]
102700813  DNA (cytosine-5)-methyltransferase 1B [KO:K00558] [EC:2.1.1.37]
102710155  DNA (cytosine-5)-methyltransferase CMT3-like [KO:K00558] [EC:2.1.1.37]
102710445  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
102709919  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
102716218  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
102720524  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
102701486  1-aminocyclopropane-1-carboxylate synthase 7 [KO:K01762] [EC:4.4.1.14]
102701155  1-aminocyclopropane-1-carboxylate synthase 1 [KO:K01762] [EC:4.4.1.14]
102712043  1-aminocyclopropane-1-carboxylate oxidase 1-like [KO:K05933] [EC:1.14.17.4]
102702913  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
102717708  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
102717987  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
102702762  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
102704086  1-aminocyclopropane-1-carboxylate oxidase 1-like [KO:K05933] [EC:1.14.17.4]
102706500  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
102712857  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
102717401  aspartokinase 1, chloroplastic [KO:K00928] [EC:2.7.2.4]
102707481  aspartokinase 1, chloroplastic isoform X2 [KO:K00928] [EC:2.7.2.4]
102716143  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
102715505  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
102699339  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
102722004  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
102709699  bifunctional aspartokinase/homoserine dehydrogenase 1 isoform X3 [KO:K00003] [EC:1.1.1.3]
102717509  cystathionine gamma-synthase 1, chloroplastic [KO:K01739] [EC:2.5.1.48]
102709311  probable cystathionine gamma-synthase 2 [KO:K01739] [EC:2.5.1.48]
102704742  probable cystathionine gamma-synthase 2 [KO:K01739] [EC:2.5.1.48]
102705012  cystathionine gamma-synthase 1, chloroplastic-like [KO:K01739] [EC:2.5.1.48]
102706925  branched-chain amino acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
102711686  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
102707583  branched-chain-amino-acid aminotransferase 5, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
102712203  branched-chain amino acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
102704498  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
102723055  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
102703014  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
102704516  glutamate--cysteine ligase B, chloroplastic [KO:K01919] [EC:6.3.2.2]
102710932  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
102706051  glutathione synthetase, chloroplastic-like isoform X2 [KO:K21456] [EC:6.3.2.3]
102718696  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
102702612  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
102716016  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
102715862  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
102701516  aspartate aminotransferase, chloroplastic [KO:K00811] [EC:2.6.1.1]
102722459  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial-like isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
102718974  thiosulfate/3-mercaptopyruvate sulfurtransferase 2-like isoform X2 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
102701608  L-lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
102720434  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
102705224  putative D-cysteine desulfhydrase 1, mitochondrial [KO:K05396] [EC:4.4.1.15]
102718687  LOW QUALITY PROTEIN: putative L-cysteine desulfhydrase 2 [KO:K22207] [EC:4.4.1.28]
102718401  putative L-cysteine desulfhydrase 1 [KO:K22207] [EC:4.4.1.28]
102703118  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
102703924  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
102707349  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
102715434  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
102717505  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
102709177  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
102722595  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
102715412  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
102702243  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
102700846  cysteine synthase-like [KO:K22846] [EC:2.5.1.144]
102713271  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
102720719  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
102710613  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
102715193  phosphoserine aminotransferase 1, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
obr00010  Glycolysis / Gluconeogenesis
obr00250  Alanine, aspartate and glutamate metabolism
obr00260  Glycine, serine and threonine metabolism
obr00290  Valine, leucine and isoleucine biosynthesis
obr00430  Taurine and hypotaurine metabolism
obr00480  Glutathione metabolism
obr00620  Pyruvate metabolism
obr00640  Propanoate metabolism
obr00770  Pantothenate and CoA biosynthesis
obr00900  Terpenoid backbone biosynthesis
obr00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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