KEGG   PATHWAY: ogo04916
Entry
ogo04916                    Pathway                                
Name
Melanogenesis - Oncorhynchus gorbuscha (pink salmon)
Description
Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortic peptides. MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. Melanin synthesis takes place within specialized intracellular organelles named melanosomes. Melanin-containing melanosomes then move from the perinuclear region to the dendrite tips and are transferred to keratinocytes by a still not well-characterized mechanism.
Class
Organismal Systems; Endocrine system
Pathway map
ogo04916  Melanogenesis
ogo04916

Organism
Oncorhynchus gorbuscha (pink salmon) [GN:ogo]
Gene
124019353  pro-opiomelanocortin [KO:K05228]
124001796  pro-opiomelanocortin A [KO:K05228]
124046762  pomca; proopiomelanocortin a [KO:K05228]
124008467  asip1; agouti signaling protein 1 [KO:K08725]
124035036  melanocyte-stimulating hormone receptor-like [KO:K04199]
124033107  melanocyte-stimulating hormone receptor-like [KO:K04199]
124009729  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
124012564  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
124045728  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
124031747  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
123997178  adcy1a; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
124010162  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
124041773  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
124043321  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
124027005  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
123995167  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
123997492  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
124005714  adenylate cyclase type 3-like isoform X1 [KO:K08043] [EC:4.6.1.1]
124043989  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
124017844  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
124031731  adcy6a; LOW QUALITY PROTEIN: adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
124046119  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
124032309  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
124033586  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
124035566  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
124009784  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
124045363  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
123999196  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
124016520  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
123994965  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
124002772  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
124003154  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
124041764  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
124027026  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
124009569  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
124043961  creb1b; cyclic AMP-responsive element-binding protein 1b isoform X1 [KO:K05870]
124008592  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
123996358  creb3l3a; cyclic AMP-responsive element-binding protein 3-like protein 3-A [KO:K09048]
123994651  creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
124034085  creb3l3l; cAMP responsive element binding protein 3-like 3 like [KO:K09048]
124041530  cyclic AMP-responsive element-binding protein 3-like protein 3-B [KO:K09048]
123997822  LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
124005469  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
124035889  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
124036553  cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
124013787  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
124037657  cyclic AMP-responsive element-binding protein 3-like protein 3-B [KO:K09048]
124032963  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
124040150  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
123998802  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
123999415  LOW QUALITY PROTEIN: CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
124015936  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
124038761  LOW QUALITY PROTEIN: histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
124016518  crebbpa; LOW QUALITY PROTEIN: histone lysine acetyltransferase CREBBP [KO:K04498] [EC:2.3.1.48]
124020673  microphthalmia-associated transcription factor-like [KO:K09455]
124032038  microphthalmia-associated transcription factor-like isoform X1 [KO:K09455]
124002349  microphthalmia-associated transcription factor-like isoform X1 [KO:K09455]
124045157  wnt1; protein Wnt-1 [KO:K03209]
124032275  protein Wnt-1-like [KO:K03209]
124003332  protein Wnt-2b-A-like [KO:K00182]
124033649  protein Wnt-2 [KO:K00182]
124003958  protein Wnt-2-like [KO:K00182]
124031586  wnt2ba; wingless-type MMTV integration site family, member 2Ba isoform X1 [KO:K00182]
124048250  proto-oncogene Wnt-3-like isoform X1 [KO:K00312]
124040891  protein Wnt-3a [KO:K00312]
124009194  protein Wnt-3a-like [KO:K00312]
124039213  proto-oncogene Wnt-3 [KO:K00312]
123996348  protein Wnt-4-like isoform X1 [KO:K00408]
124003452  protein Wnt-4a [KO:K00408]
124020085  protein Wnt-4a-like [KO:K00408]
124005200  protein Wnt-4-like [KO:K00408]
123994361  wnt5b; protein Wnt-5b [KO:K00444]
124045577  wnt5a; protein Wnt-5a [KO:K00444]
124042034  protein Wnt-6-like [KO:K00445]
124043804  protein Wnt-6-like [KO:K00445]
123995675  wnt7ba; protein Wnt-7b [KO:K00572]
124021327  LOW QUALITY PROTEIN: protein Wnt-7a [KO:K00572]
124014286  protein Wnt-7b-like [KO:K00572]
124037640  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
124045673  protein Wnt-7a-like [KO:K00572]
124038508  protein Wnt-7b-like isoform X1 [KO:K00572]
123994162  protein Wnt-8a-like [KO:K00714]
123994163  protein Wnt-8a-like [KO:K00714]
124040722  protein Wnt-8b-like [KO:K00714]
124037259  protein Wnt-8b [KO:K00714]
124010200  wnt9a; protein Wnt-9a [KO:K01064]
124041738  protein Wnt-9a-like [KO:K01064]
124000159  protein Wnt-9b-like [KO:K01064]
124015035  protein Wnt-9b-like [KO:K01064]
124016107  protein Wnt-9b-like [KO:K01064]
124043805  protein Wnt-10a-like [KO:K01357]
124045156  wnt10b; protein Wnt-10b [KO:K01357]
124016096  protein Wnt-10a [KO:K01357]
124032273  protein Wnt-10b-like [KO:K01357]
123994207  protein Wnt-11-like [KO:K01384]
123994527  protein Wnt-11-like [KO:K01384]
123998570  wnt11f2; protein Wnt-11 [KO:K01384]
124000859  protein Wnt-11-like [KO:K01384]
123995807  protein Wnt-16-like [KO:K01558]
124014327  protein Wnt-16-like [KO:K01558]
124011354  frizzled-7-A-like [KO:K02432]
124035089  frizzled-7-A-like [KO:K02432]
123997942  frizzled-1-like [KO:K02432]
124035183  frizzled-7-A-like [KO:K02432]
124005987  frizzled-1-like [KO:K02432]
124043435  frizzled-1-like [KO:K02432]
124008527  frizzled-7-A-like [KO:K02432]
123996591  atrial natriuretic peptide-converting enzyme-like [KO:K02235]
124000131  frizzled-2-like [KO:K02235]
124016184  frizzled-2-like [KO:K02235]
123995842  frizzled-3-like [KO:K02329]
123990959  frizzled-3-like [KO:K02329]
124046323  frizzled-3-like isoform X1 [KO:K02329]
124002285  frizzled-3-like isoform X1 [KO:K02329]
123992551  frizzled-4-like [KO:K02354]
124006474  frizzled-4-like [KO:K02354]
123990194  fzd8a; frizzled-8a [KO:K02375]
124010234  frizzled-8-like [KO:K02375]
124048369  fzd5; frizzled-5 [KO:K02375]
124041917  frizzled-8-like [KO:K02375]
124008424  frizzled-5-like [KO:K02375]
123997964  frizzled-6-like [KO:K02376]
124005711  frizzled-6-like [KO:K02376]
123992888  frizzled-9-like [KO:K02842]
123994672  frizzled-9-like [KO:K02842]
124034370  frizzled-10-like [KO:K02842]
124005583  frizzled-9-like [KO:K02842]
124036239  frizzled-10-B-like [KO:K02842]
123999930  frizzled-9 [KO:K02842]
124033726  guanine nucleotide-binding protein G(o) subunit alpha-like [KO:K04534]
124035708  guanine nucleotide-binding protein G(o) subunit alpha-like [KO:K04534]
124037245  guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
124000492  guanine nucleotide-binding protein G(o) subunit alpha-like isoform X1 [KO:K04534]
123997052  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04634]
124048624  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
124034538  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
124036062  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
123999214  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04634]
124037689  gna11b; guanine nucleotide-binding protein subunit alpha-11b isoform X1 [KO:K04634]
123994753  segment polarity protein dishevelled homolog DVL-2-like isoform X1 [KO:K02353]
123994803  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
124009757  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
124041993  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
124014234  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
124008426  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
124045909  segment polarity protein dishevelled homolog DVL-1-like isoform X1 [KO:K02353]
124032088  segment polarity protein dishevelled homolog DVL-1-like isoform X1 [KO:K02353]
124010592  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
124044135  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
124045724  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
124008362  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
124019950  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
123999056  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K02620]
124013670  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K02620]
124034311  transcription factor 7-like 1-B isoform X1 [KO:K04490]
124049101  transcription factor 7-like 1-B isoform X1 [KO:K04490]
124036311  LOW QUALITY PROTEIN: transcription factor 7-like 1-B [KO:K04490]
124006940  tcf7l1a; transcription factor 7-like 1-A isoform X1 [KO:K04490]
124039973  transcription factor 7-like 2 isoform X1 [KO:K04491]
124048226  tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
124001502  LOW QUALITY PROTEIN: lymphoid enhancer-binding factor 1-like [KO:K04492]
123995882  uncharacterized protein LOC123995882 [KO:K05461]
124033531  kitlga; kit ligand a [KO:K05461]
124003995  kit ligand-like [KO:K05461]
123997190  mast/stem cell growth factor receptor Kit-like isoform X1 [KO:K05091] [EC:2.7.10.1]
124018481  mast/stem cell growth factor receptor kita-like [KO:K05091] [EC:2.7.10.1]
124037858  mast/stem cell growth factor receptor Kit-like isoform X1 [KO:K05091] [EC:2.7.10.1]
124035796  GTPase HRas [KO:K02833]
124002027  GTPase HRas-like [KO:K02833]
124020877  GTPase HRas-like [KO:K07827]
124035184  GTPase KRas isoform X1 [KO:K07827]
124002488  kras; GTPase KRas isoform X1 [KO:K07827]
124045679  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
124031697  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
124037367  map2k1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124037445  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
123997082  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
124037664  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
124009586  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
124034739  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
124036684  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124037950  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124000779  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124005778  tyr; tyrosinase [KO:K00505] [EC:1.14.18.1]
124013126  tyrosinase-like [KO:K00505] [EC:1.14.18.1]
124044371  tyrosinase-like [KO:K00505] [EC:1.14.18.1]
124023358  5,6-dihydroxyindole-2-carboxylic acid oxidase-like isoform X1 [KO:K00506] [EC:1.14.18.-]
124014171  5,6-dihydroxyindole-2-carboxylic acid oxidase-like [KO:K00506] [EC:1.14.18.-]
124008475  5,6-dihydroxyindole-2-carboxylic acid oxidase-like [KO:K00506] [EC:1.14.18.-]
124042904  L-dopachrome tautomerase-like [KO:K01827] [EC:5.3.3.12]
124043915  LOW QUALITY PROTEIN: L-dopachrome tautomerase-like [KO:K01827] [EC:5.3.3.12]
124030708  L-dopachrome tautomerase-like [KO:K01827] [EC:5.3.3.12]
124012722  endothelin-1-like [KO:K16366]
124042738  edn1; endothelin-1 [KO:K16366]
123994228  endothelin receptor type B-like [KO:K04198]
124010134  endothelin receptor type B-like [KO:K04198]
124040847  endothelin receptor type B-like [KO:K04198]
124044472  endothelin receptor type B-like [KO:K04198]
123994437  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
124003571  gnai2b; guanine nucleotide-binding protein G(i) subunit alpha-2b [KO:K04630]
124004229  guanine nucleotide-binding protein G(i) subunit alpha-3-like [KO:K04630]
124004356  guanine nucleotide-binding protein G(i) subunit alpha-2-like isoform X1 [KO:K04630]
124035303  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
124014006  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
124044985  guanine nucleotide-binding protein G(i) subunit alpha-3-like [KO:K04630]
124031253  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
124031303  guanine nucleotide-binding protein G(i) subunit alpha-3-like [KO:K04630]
124031574  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
124002451  guanine nucleotide-binding protein G(i) subunit alpha-1-like isoform X1 [KO:K04630]
124032374  guanine nucleotide-binding protein G(i) subunit alpha-3-like isoform X1 [KO:K04630]
123990995  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
123990996  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
123995278  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
123995279  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
124013828  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
124008217  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
124046398  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like [KO:K05858] [EC:3.1.4.11]
124046548  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
124002240  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
124002317  plcb2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
123990895  calmodulin-A isoform X1 [KO:K02183]
123993069  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
123995385  calmodulin-1 [KO:K02183]
124017992  calm1a; calmodulin-1a [KO:K02183]
124011142  calml4b; calmodulin-like protein 4 isoform X1 [KO:K02183]
124041381  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
124005296  calmodulin-1 [KO:K02183]
124035491  calmodulin-like protein 4 [KO:K02183]
124022801  calmodulin-like protein 4 [KO:K02183]
124025548  calmodulin-like protein 4 [KO:K02183]
124006994  calmodulin-1 [KO:K02183]
124007773  calmodulin-1 [KO:K02183]
124001270  calmodulin-1 [KO:K02183]
124038162  calmodulin-1 [KO:K02183]
124017156  calglandulin-like [KO:K02183]
123989345  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
124040066  calcium/calmodulin-dependent protein kinase type II delta chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
124048133  calcium/calmodulin-dependent protein kinase type II subunit delta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
124034029  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
124041281  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
124005769  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
124036602  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
124006676  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
124006684  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
124026272  calcium/calmodulin-dependent protein kinase type II delta 2 chain-like [KO:K04515] [EC:2.7.11.17]
124027516  calcium/calmodulin-dependent protein kinase type II subunit delta-like [KO:K04515] [EC:2.7.11.17]
124014458  calcium/calmodulin-dependent protein kinase type II delta chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
124008153  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
124004184  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123998962  prkcab; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
124015685  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
124021143  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
124017080  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
124005945  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05606  Melanin
Reference
PMID:15383650
  Authors
Slominski A, Tobin DJ, Shibahara S, Wortsman J.
  Title
Melanin pigmentation in mammalian skin and its hormonal regulation.
  Journal
Physiol Rev 84:1155-228 (2004)
DOI:10.1152/physrev.00044.2003
Reference
PMID:10841026
  Authors
Busca R, Ballotti R.
  Title
Cyclic AMP a key messenger in the regulation of skin pigmentation.
  Journal
Pigment Cell Res 13:60-9 (2000)
DOI:10.1034/j.1600-0749.2000.130203.x
Reference
PMID:15016298
  Authors
Imokawa G.
  Title
Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders.
  Journal
Pigment Cell Res 17:96-110 (2004)
DOI:10.1111/j.1600-0749.2003.00126.x
Reference
PMID:11023702
  Authors
Wikberg JE, Muceniece R, Mandrika I, Prusis P, Lindblom J, Post C, Skottner A.
  Title
New aspects on the melanocortins and their receptors.
  Journal
Pharmacol Res 42:393-420 (2000)
DOI:10.1006/phrs.2000.0725
Reference
PMID:12894244
  Authors
Chin L.
  Title
The genetics of malignant melanoma: lessons from mouse and man.
  Journal
Nat Rev Cancer 3:559-70 (2003)
DOI:10.1038/nrc1145
Reference
PMID:16822996
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
PMID:12753399
  Authors
Saito H, Yasumoto K, Takeda K, Takahashi K, Yamamoto H, Shibahara S.
  Title
Microphthalmia-associated transcription factor in the Wnt signaling pathway.
  Journal
Pigment Cell Res 16:261-5 (2003)
DOI:10.1034/j.1600-0749.2003.00039.x
Reference
PMID:9263329
  Authors
Imokawa G, Kobayashi T, Miyagishi M, Higashi K, Yada Y.
  Title
The role of endothelin-1 in epidermal hyperpigmentation and signaling mechanisms of mitogenesis and melanogenesis.
  Journal
Pigment Cell Res 10:218-28 (1997)
DOI:10.1111/j.1600-0749.1997.tb00488.x
Reference
PMID:10643996
  Authors
Park HY, Gilchrest BA.
  Title
Signaling pathways mediating melanogenesis.
  Journal
Cell Mol Biol (Noisy-le-grand) 45:919-30 (1999)
Reference
PMID:10347209
  Authors
Park HY, Perez JM, Laursen R, Hara M, Gilchrest BA.
  Title
Protein kinase C-beta activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain.
  Journal
J Biol Chem 274:16470-8 (1999)
DOI:10.1074/jbc.274.23.16470
Reference
PMID:11602344
  Authors
Sturm RA, Teasdale RD, Box NF.
  Title
Human pigmentation genes: identification, structure and consequences of polymorphic variation.
  Journal
Gene 277:49-62 (2001)
DOI:10.1016/S0378-1119(01)00694-1
Reference
PMID:11041354
  Authors
Hearing VJ.
  Title
The melanosome: the perfect model for cellular responses to the environment.
  Journal
Pigment Cell Res 13 Suppl 8:23-34 (2000)
DOI:10.1034/j.1600-0749.13.s8.7.x
Reference
PMID:16246839
  Authors
Molina DM, Grewal S, Bardwell L.
  Title
Characterization of an ERK-binding domain in microphthalmia-associated transcription factor and differential inhibition of ERK2-mediated substrate phosphorylation.
  Journal
J Biol Chem 280:42051-60 (2005)
DOI:10.1074/jbc.M510590200
Related
pathway
ogo00350  Tyrosine metabolism
ogo04010  MAPK signaling pathway
ogo04310  Wnt signaling pathway
KO pathway
ko04916   
LinkDB

DBGET integrated database retrieval system