KEGG   PATHWAY: oki04216
Entry
oki04216                    Pathway                                
Name
Ferroptosis - Oncorhynchus kisutch (coho salmon)
Description
Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer cell and certain normal cells. It is involved in multiple physiological and pathological processes, such as cancer cell death, neurodegenerative disease, tissue damage and acute renal failure.
Class
Cellular Processes; Cell growth and death
Pathway map
oki04216  Ferroptosis
oki04216

Other DBs
GO: 0097707
Organism
Oncorhynchus kisutch (coho salmon) [GN:oki]
Gene
109897153  4F2 cell-surface antigen heavy chain-like [KO:K06519]
109872800  4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519]
109874015  slc3a2; 4F2 cell-surface antigen heavy chain [KO:K06519]
109905420  4F2 cell-surface antigen heavy chain isoform X2 [KO:K06519]
109896583  cystine/glutamate transporter-like isoform X1 [KO:K13869]
109896609  cystine/glutamate transporter-like isoform X1 [KO:K13869]
109910249  cystine/glutamate transporter [KO:K13869]
109906014  slc7a11; cystine/glutamate transporter [KO:K13869]
109897084  cellular tumor antigen p53-like isoform X1 [KO:K04451]
109906265  cellular tumor antigen p53-like [KO:K04451]
109873031  tp53; cellular tumor antigen p53 isoform X2 [KO:K04451]
109870235  glutamate--cysteine ligase catalytic subunit isoform X1 [KO:K11204] [EC:6.3.2.2]
109899867  glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]
109902612  glutamate--cysteine ligase regulatory subunit isoform X1 [KO:K11205]
109882206  glutamate--cysteine ligase regulatory subunit-like isoform X1 [KO:K11205]
109908009  gss; glutathione synthetase [KO:K21456] [EC:6.3.2.3]
109889213  phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K05361] [EC:1.11.1.12]
109905002  long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
109875652  long-chain-fatty-acid--CoA ligase 4-like isoform X1 [KO:K01897] [EC:6.2.1.3]
109878598  long-chain-fatty-acid--CoA ligase 4 [KO:K01897] [EC:6.2.1.3]
109892959  long-chain-fatty-acid--CoA ligase 6-like [KO:K01897] [EC:6.2.1.3]
109892650  long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
109871973  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
109872242  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
109901038  acsl1; long-chain-fatty-acid--CoA ligase 1 isoform X2 [KO:K01897] [EC:6.2.1.3]
109872828  long-chain-fatty-acid--CoA ligase 6-like isoform X1 [KO:K01897] [EC:6.2.1.3]
109882820  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
109894210  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
109865554  acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
109875162  long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
109895876  long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
109910315  lysophospholipid acyltransferase 5-like [KO:K13515] [EC:2.3.1.23 2.3.1.-]
109902177  lysophospholipid acyltransferase 5 isoform X1 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
109867768  diamine acetyltransferase 2 [KO:K00657] [EC:2.3.1.57]
109897007  diamine acetyltransferase 2 [KO:K00657] [EC:2.3.1.57]
109909897  diamine acetyltransferase 1 isoform X2 [KO:K00657] [EC:2.3.1.57]
109899230  diamine acetyltransferase 1-like isoform X1 [KO:K00657] [EC:2.3.1.57]
109872636  diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]
109899234  diamine acetyltransferase 1-like [KO:K00657] [EC:2.3.1.57]
109873711  diamine acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
109872107  serotransferrin isoform X1 [KO:K14736]
109909891  transferrin receptor protein 1-like [KO:K06503]
109872237  transferrin receptor protein 1 [KO:K06503]
109899240  tfrc; transferrin receptor protein 1 isoform X1 [KO:K06503]
109878161  metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
109869105  metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
109869355  natural resistance-associated macrophage protein 2 [KO:K21398]
109891210  natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
109894482  natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
109876822  slc39a8; zinc transporter ZIP8 isoform X1 [KO:K14714]
109894962  zinc transporter ZIP14-like isoform X1 [KO:K14720]
109899857  pcbp2; poly(rC)-binding protein 2 isoform X1 [KO:K13162]
109869401  poly(rC)-binding protein 2 isoform X1 [KO:K13162]
109890788  poly(rC)-binding protein 2 isoform X1 [KO:K13162]
109907804  poly(rC)-binding protein 2 isoform X1 [KO:K13162]
109876449  solute carrier family 40 member 1-like [KO:K14685]
109871106  slc40a1; solute carrier family 40 member 1 [KO:K14685]
109902431  solute carrier family 40 member 1 [KO:K14685]
109882668  cp; ceruloplasmin [KO:K13624] [EC:1.16.3.1]
109888425  ferritin, heavy subunit [KO:K00522] [EC:1.16.3.1]
116352982  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116373380  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116373381  ferritin, middle subunit [KO:K00522] [EC:1.16.3.1]
116373382  ferritin, middle subunit [KO:K00522] [EC:1.16.3.1]
116373384  ferritin, middle subunit [KO:K00522] [EC:1.16.3.1]
116373385  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116373386  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109888176  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109884794  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116373387  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116373388  ferritin, middle subunit-like isoform X1 [KO:K00522] [EC:1.16.3.1]
116373389  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116373390  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116374428  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116374429  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109884797  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116374432  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116374433  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116374434  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109884796  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116374435  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116374436  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116374438  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116374439  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116374440  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109893145  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109893146  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109893147  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109865509  ferritin, lower subunit [KO:K00522] [EC:1.16.3.1]
109881448  ferritin, heavy subunit-like [KO:K00522] [EC:1.16.3.1]
109882076  ferritin, heavy subunit [KO:K00522] [EC:1.16.3.1]
116362524  ferritin, middle subunit [KO:K00522] [EC:1.16.3.1]
116362525  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116362526  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116362527  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116362529  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116362530  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116362532  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116362533  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116362535  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109884799  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116365437  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116365438  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116365439  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116365440  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116368516  ferritin, middle subunit [KO:K00522] [EC:1.16.3.1]
116368517  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116352967  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
116369019  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109884795  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
109884798  ferritin, middle subunit [KO:K00522] [EC:1.16.3.1]
109889247  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
109890773  microtubule-associated proteins 1A/1B light chain 3A isoform X2 [KO:K10435]
109864477  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
109865846  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
109867375  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
109895888  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
109901994  autophagy protein 5 [KO:K08339]
109908311  autophagy protein 5-like isoform X1 [KO:K08339]
109884679  atg7; LOW QUALITY PROTEIN: ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
109889841  nuclear receptor coactivator 4 isoform X1 [KO:K09289]
109899648  nuclear receptor coactivator 4 isoform X2 [KO:K09289]
109876403  heme oxygenase [KO:K00510] [EC:1.14.14.18]
109898653  heme oxygenase-like [KO:K00510] [EC:1.14.14.18]
109893520  heme oxygenase-like [KO:K00510] [EC:1.14.14.18]
116355451  heme oxygenase-like [KO:K00510] [EC:1.14.14.18]
116355452  heme oxygenase-like [KO:K00510] [EC:1.14.14.18]
109890054  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
109870163  voltage-dependent anion-selective channel protein 2 [KO:K15040]
109899809  voltage-dependent anion-selective channel protein 2 [KO:K15040]
109899945  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
109868551  voltage-dependent anion-selective channel protein 2 isoform X3 [KO:K15041]
109896030  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
109881382  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
109882566  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
109875970  cytochrome b-245 heavy chain-like [KO:K21421] [EC:1.-.-.-]
116354027  cytochrome b-245 heavy chain-like [KO:K21421] [EC:1.-.-.-]
Compound
C00010  CoA
C00024  Acetyl-CoA
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00032  Heme
C00051  Glutathione
C00097  L-Cysteine
C00127  Glutathione disulfide
C00129  Isopentenyl diphosphate
C00219  Arachidonate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00418  (R)-Mevalonate
C00491  L-Cystine
C00669  gamma-L-Glutamyl-L-cysteine
C02249  Arachidonyl-CoA
C02477  alpha-Tocopherol
C11378  Ubiquinone-10
C14818  Fe2+
C14819  Fe3+
C16170  (7Z,10Z,13Z,16Z)-Docosatetraenoyl-CoA
C16527  Adrenic acid
C16844  Hydroxyl radical
C21478  Erastin
C21479  RSL3
C21480  1-Octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21481  1-Octadecanoyl-2-(7Z,10Z,13Z,16Z-docosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21482  1-Octadecanoyl-2-(15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21483  1-Octadecanoyl-2-(15S-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine
C21484  1-Octadecanoyl-sn-glycero-3-phosphoethanolamine
D00448  Sulfasalazine (USP/INN)
D08524  Sorafenib (USAN/INN)
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:26653790
  Authors
Yang WS, Stockwell BR
  Title
Ferroptosis: Death by Lipid Peroxidation.
  Journal
Trends Cell Biol 26:165-76 (2016)
DOI:10.1016/j.tcb.2015.10.014
Reference
PMID:27842066
  Authors
Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B, Tyurin VA, Ritov VB, Kapralov AA, Amoscato AA, Jiang J, Anthonymuthu T, Mohammadyani D, Yang Q, Proneth B, Klein-Seetharaman J, Watkins S, Bahar I, Greenberger J, Mallampalli RK, Stockwell BR, Tyurina YY, Conrad M, Bayir H
  Title
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.
  Journal
Nat Chem Biol 13:81-90 (2017)
DOI:10.1038/nchembio.2238
Reference
PMID:27842067
  Authors
D'Herde K, Krysko DV
  Title
Ferroptosis: Oxidized PEs trigger death.
  Journal
Nat Chem Biol 13:4-5 (2017)
DOI:10.1038/nchembio.2261
Reference
PMID:28082232
  Authors
Guiney SJ, Adlard PA, Bush AI, Finkelstein DI, Ayton S
  Title
Ferroptosis and cell death mechanisms in Parkinson's disease.
  Journal
Neurochem Int 104:34-48 (2017)
DOI:10.1016/j.neuint.2017.01.004
Reference
PMID:26725301
  Authors
Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y
  Title
Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.
  Journal
Trends Biochem Sci 41:274-86 (2016)
DOI:10.1016/j.tibs.2015.11.012
Reference
PMID:26794443
  Authors
Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R, Tang D
  Title
Ferroptosis: process and function.
  Journal
Cell Death Differ 23:369-79 (2016)
DOI:10.1038/cdd.2015.158
Reference
PMID:27791175
  Authors
Murphy ME
  Title
Ironing out how p53 regulates ferroptosis.
  Journal
Proc Natl Acad Sci U S A 113:12350-12352 (2016)
DOI:10.1073/pnas.1615159113
Reference
PMID:28129536
  Authors
Muckenthaler MU, Rivella S, Hentze MW, Galy B
  Title
A Red Carpet for Iron Metabolism.
  Journal
Cell 168:344-361 (2017)
DOI:10.1016/j.cell.2016.12.034
Reference
PMID:27860262
  Authors
Yu H, Guo P, Xie X, Wang Y, Chen G
  Title
Ferroptosis, a new form of cell death, and its relationships with tumourous diseases.
  Journal
J Cell Mol Med 21:648-657 (2017)
DOI:10.1111/jcmm.13008
Reference
PMID:27314071
  Authors
Wang SJ, Ou Y, Jiang L, Gu W
  Title
Ferroptosis: A missing puzzle piece in the p53 blueprint?
  Journal
Mol Cell Oncol 3:e1046581 (2016)
DOI:10.1080/23723556.2015.1046581
Reference
PMID:27048822
  Authors
Cao JY, Dixon SJ
  Title
Mechanisms of ferroptosis.
  Journal
Cell Mol Life Sci 73:2195-209 (2016)
DOI:10.1007/s00018-016-2194-1
Reference
PMID:26436293
  Authors
Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, Liu Y, Goessling W, Kimmelman AC, Harper JW
  Title
Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.
  Journal
Elife 4:e10308 (2015)
DOI:10.7554/eLife.10308
Reference
PMID:28066232
  Authors
Wang YQ, Chang SY, Wu Q, Gou YJ, Jia L, Cui YM, Yu P, Shi ZH, Wu WS, Gao G, Chang YZ
  Title
The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis.
  Journal
Front Aging Neurosci 8:308 (2016)
DOI:10.3389/fnagi.2016.00308
Reference
PMID:26405158
  Authors
Kwon MY, Park E, Lee SJ, Chung SW
  Title
Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death.
  Journal
Oncotarget 6:24393-403 (2015)
DOI:10.18632/oncotarget.5162
Reference
PMID:22632964
  Authors
Reed JC, Pellecchia M
  Title
Ironing out cell death mechanisms.
  Journal
Cell 149:963-5 (2012)
DOI:10.1016/j.cell.2012.05.009
Related
pathway
oki00480  Glutathione metabolism
oki00900  Terpenoid backbone biosynthesis
KO pathway
ko04216   
LinkDB

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