KEGG   PATHWAY: oki04340
Entry
oki04340                    Pathway                                
Name
Hedgehog signaling pathway - Oncorhynchus kisutch (coho salmon)
Description
The Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for transduction of the Hedgehog signal in vertebrates. In Hh's absence, the Ptch receptor localizes to the cilium, where it inhibits Smo activation. Gli proteins are phosphorylated by PKA, CKI and GSK3B and partially degraded into truncated Gli repressor form (GliR) that suppresses Hh target gene transcription in the nucleus. In Hh's presence, Ptch disappears from the cilium, and activated Smo contributes to the translocation of the protein complex Gli, Sufu, Kif7 to ciliary tip, where Gli dissociates from the negative regulator Sufu. The production of Gli activator form (GliA) occurs and the increased nuclear accumulation of GliA results in activation transcription of Hh target genes.
Class
Environmental Information Processing; Signal transduction
Pathway map
oki04340  Hedgehog signaling pathway
oki04340

Organism
Oncorhynchus kisutch (coho salmon) [GN:oki]
Gene
116357717  ptch1; LOW QUALITY PROTEIN: protein patched homolog 1 [KO:K06225]
109894934  protein patched homolog 1-like isoform X1 [KO:K06225]
109872322  protein patched homolog 1 [KO:K11101]
109875463  protein patched homolog 1 [KO:K11101]
109876766  smo; smoothened homolog [KO:K06226]
116366453  smoothened homolog [KO:K06226]
109871416  gpr161; G-protein coupled receptor 161 [KO:K08439]
109886804  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
109880753  cAMP-dependent protein kinase catalytic subunit alpha-like isoform X1 [KO:K04345] [EC:2.7.11.11]
109871709  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
109898739  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
109866517  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109874831  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109905049  casein kinase I isoform X2 [KO:K08957] [EC:2.7.11.1]
109864541  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
109889500  casein kinase I isoform X1 [KO:K08958] [EC:2.7.11.1]
116357801  casein kinase I-like isoform X1 [KO:K08958] [EC:2.7.11.1]
109882229  casein kinase I isoform X1 [KO:K08958] [EC:2.7.11.1]
109876610  casein kinase I isoform X1 [KO:K08958] [EC:2.7.11.1]
109897913  casein kinase I isoform X1 [KO:K08958] [EC:2.7.11.1]
109902576  casein kinase I isoform X3 [KO:K08958] [EC:2.7.11.1]
109866866  casein kinase I-like isoform X1 [KO:K08958] [EC:2.7.11.1]
109876714  casein kinase I [KO:K08959] [EC:2.7.11.1]
109870115  csnk1d; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
116359836  LOW QUALITY PROTEIN: casein kinase I-like [KO:K08959] [EC:2.7.11.1]
109888145  casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
109869937  casein kinase I-like [KO:K08960] [EC:2.7.11.1]
109898597  casein kinase I [KO:K08960] [EC:2.7.11.1]
109900002  casein kinase I-like [KO:K08960] [EC:2.7.11.1]
109884375  casein kinase I isoform X2 [KO:K08960] [EC:2.7.11.1]
109870679  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
109890683  glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
109906776  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
109869785  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
109890135  zinc finger protein GLI1 [KO:K16797]
109866703  zinc finger protein GLI1-like [KO:K16797]
109906701  zinc finger protein GLI2 [KO:K16798]
109890624  zinc finger protein GLI2 [KO:K16798]
109871276  gli2; zinc finger protein GLI2 isoform X1 [KO:K16798]
109868181  zinc finger protein GLI2-like [KO:K16798]
109908822  transcriptional activator GLI3 isoform X1 [KO:K06230]
109899441  transcriptional activator GLI3-like isoform X1 [KO:K06230]
109889742  suppressor of fused homolog isoform X1 [KO:K06229]
109899565  suppressor of fused homolog [KO:K06229]
109888396  kinesin-like protein kif7 [KO:K18806]
109895234  kinesin-like protein kif7 isoform X1 [KO:K18806]
109901298  hedgehog-interacting protein [KO:K06231]
109880572  hedgehog-interacting protein-like [KO:K06231]
109889644  G1/S-specific cyclin-D1-like isoform X1 [KO:K04503]
109895467  G1/S-specific cyclin-D1 [KO:K04503]
109867514  G1/S-specific cyclin-D1-like [KO:K04503]
109885836  G1/S-specific cyclin-D1 [KO:K04503]
109889568  G1/S-specific cyclin-D2 isoform X2 [KO:K10151]
109897410  G1/S-specific cyclin-D2-like [KO:K10151]
109896687  G1/S-specific cyclin-D2-like [KO:K10151]
109864549  G1/S-specific cyclin-D2 [KO:K10151]
109883676  G1/S-specific cyclin-D2-like [KO:K10151]
109867280  G1/S-specific cyclin-D2 isoform X2 [KO:K10151]
109909828  apoptosis regulator Bcl-2-like [KO:K02161]
109899300  apoptosis regulator Bcl-2-like [KO:K02161]
109872384  apoptosis regulator Bcl-2-like [KO:K02161]
109874825  apoptosis regulator Bcl-2-like [KO:K02161]
109909924  cullin-1 [KO:K03347]
109871771  cullin-1 [KO:K03347]
109874683  cullin-1-like isoform X2 [KO:K03347]
109878409  F-box/WD repeat-containing protein 11 isoform X2 [KO:K03362]
109892548  F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
109872827  F-box/WD repeat-containing protein 11-like [KO:K03362]
109864689  F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
109899805  hhat; protein-cysteine N-palmitoyltransferase HHAT [KO:K24678] [EC:2.3.1.-]
109885123  hhatl; protein-cysteine N-palmitoyltransferase HHAT-like protein [KO:K24679]
109874832  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X2 [KO:K24679]
109909585  sonic hedgehog protein A-like [KO:K11988]
109899051  sonic hedgehog protein A-like [KO:K11988]
109871542  tiggy-winkle hedgehog protein-like [KO:K11988]
109874701  tiggy-winkle hedgehog protein-like [KO:K11988]
109875783  indian hedgehog B protein-like [KO:K11989]
109885041  indian hedgehog B protein-like [KO:K11989]
109885758  indian hedgehog B protein-like [KO:K11989]
109878416  indian hedgehog protein-like [KO:K11990]
109869479  indian hedgehog protein [KO:K11990]
109900808  protein dispatched homolog 1-like [KO:K24680]
109866515  protein dispatched homolog 1 isoform X2 [KO:K24680]
109894980  signal peptide, CUB and EGF-like domain-containing protein 2 isoform X1 [KO:K24706]
109874897  signal peptide, CUB and EGF-like domain-containing protein 2 [KO:K24706]
109899261  brother of CDO [KO:K20020]
109909883  brother of CDO-like [KO:K20020]
109883735  LOW QUALITY PROTEIN: cell adhesion molecule-related/down-regulated by oncogenes [KO:K20033]
109868660  growth arrest-specific protein 1-like [KO:K06232]
109892391  growth arrest-specific protein 1 [KO:K06232]
109884560  growth arrest-specific protein 1 [KO:K06232]
109888462  growth arrest-specific protein 1 [KO:K06232]
116374883  growth arrest-specific protein 1-like [KO:K06232]
109871228  lrp2; low-density lipoprotein receptor-related protein 2 isoform X1 [KO:K06233]
109876922  low-density lipoprotein receptor-related protein 2-like isoform X1 [KO:K06233]
109866451  low-density lipoprotein receptor-related protein 2 isoform X3 [KO:K06233]
109865177  low-density lipoprotein receptor-related protein 2 [KO:K06233]
109876364  uncharacterized protein C16orf52 homolog B [KO:K23663]
109869909  uncharacterized protein C16orf52 homolog B-like isoform X1 [KO:K23663]
109900054  uncharacterized protein C16orf52 homolog B isoform X1 [KO:K23663]
109900724  megf8; multiple epidermal growth factor-like domains protein 8 isoform X1 [KO:K23664]
109878882  multiple epidermal growth factor-like domains protein 8 [KO:K23664]
109898482  probable E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
109891942  probable E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
109886850  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SMURF1-like [KO:K04678] [EC:2.3.2.26]
109892006  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
109875959  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
116359917  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
109898663  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
109865717  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
109881237  LOW QUALITY PROTEIN: beta-adrenergic receptor kinase 2-like [KO:K00910] [EC:2.7.11.15]
109898666  evc; ellis-van Creveld syndrome protein [KO:K19605]
109892098  evc2; limbin isoform X2 [KO:K19608]
109902853  efcab7; EF-hand calcium-binding domain-containing protein 7 [KO:K23852]
116352791  IQ domain-containing protein E-like [KO:K24677]
109882182  IQ domain-containing protein E isoform X1 [KO:K24677]
109882631  beta-arrestin-2-like [KO:K04439]
109892693  arrestin red cell isoform X1 [KO:K04439]
109896346  arrestin red cell-like isoform X1 [KO:K04439]
109872453  arrestin red cell [KO:K04439]
109883079  beta-arrestin-1 [KO:K04439]
109879494  kinesin-like protein KIF3A isoform X1 [KO:K10394]
109881224  kinesin-like protein KIF3A isoform X1 [KO:K10394]
109905363  cullin-3 [KO:K03869]
109908846  cullin-3-like isoform X2 [KO:K03869]
109876350  cullin-3-like [KO:K03869]
109872391  cullin-3 isoform X2 [KO:K03869]
109876156  speckle-type POZ protein-like A isoform X1 [KO:K10523]
109878682  speckle-type POZ protein [KO:K10523]
109865582  speckle-type POZ protein [KO:K10523]
109882227  speckle-type POZ protein [KO:K10523]
109885594  speckle-type POZ protein-like A [KO:K10523]
Compound
C00575  3',5'-Cyclic AMP
Reference
PMID:26875496
  Authors
Xavier GM, Seppala M, Barrell W, Birjandi AA, Geoghegan F, Cobourne MT
  Title
Hedgehog receptor function during craniofacial development.
  Journal
Dev Biol 415:198-215 (2016)
DOI:10.1016/j.ydbio.2016.02.009
Reference
PMID:23719536
  Authors
Briscoe J, Therond PP
  Title
The mechanisms of Hedgehog signalling and its roles in development and disease.
  Journal
Nat Rev Mol Cell Biol 14:416-29 (2013)
DOI:10.1038/nrm3598
Reference
PMID:26077918
  Authors
Alman BA
  Title
The role of hedgehog signalling in skeletal health and disease.
  Journal
Nat Rev Rheumatol 11:552-60 (2015)
DOI:10.1038/nrrheum.2015.84
Reference
PMID:26064136
  Authors
Mooney CJ, Hakimjavadi R, Fitzpatrick E, Kennedy E, Walls D, Morrow D, Redmond EM, Cahill PA
  Title
Hedgehog and Resident Vascular Stem Cell Fate.
  Journal
Stem Cells Int 2015:468428 (2015)
DOI:10.1155/2015/468428
Reference
PMID:23799571
  Authors
Sasai N, Briscoe J
  Title
Primary cilia and graded Sonic Hedgehog signaling.
  Journal
Wiley Interdiscip Rev Dev Biol 1:753-72 (2012)
DOI:10.1002/wdev.43
Reference
PMID:20708941
  Authors
Heretsch P, Tzagkaroulaki L, Giannis A
  Title
Modulators of the hedgehog signaling pathway.
  Journal
Bioorg Med Chem 18:6613-24 (2010)
DOI:10.1016/j.bmc.2010.07.038
Reference
PMID:22534646
  Authors
Anderson E, Peluso S, Lettice LA, Hill RE
  Title
Human limb abnormalities caused by disruption of hedgehog signaling.
  Journal
Trends Genet 28:364-73 (2012)
DOI:10.1016/j.tig.2012.03.012
Reference
PMID:18583599
  Authors
Rohatgi R, Scott MP
  Title
Cell biology. Arrestin' movement in cilia.
  Journal
Science 320:1726-7 (2008)
DOI:10.1126/science.1160448
Reference
PMID:24925320
  Authors
Yue S, Tang LY, Tang Y, Tang Y, Shen QH, Ding J, Chen Y, Zhang Z, Yu TT, Zhang YE, Cheng SY
  Title
Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.
  Journal
Elife 3:e02555 (2014)
DOI:10.7554/eLife.02555
Reference
PMID:22056910
  Authors
Ok CY, Singh RR, Vega F
  Title
Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms.
  Journal
Am J Pathol 180:2-11 (2012)
DOI:10.1016/j.ajpath.2011.09.009
Reference
PMID:26366162
  Authors
Hsia EY, Gui Y, Zheng X
  Title
Regulation of Hedgehog signaling by ubiquitination.
  Journal
Front Biol (Beijing) 10:203-220 (2015)
DOI:10.1007/s11515-015-1343-5
Reference
PMID:29290584
  Authors
Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R
  Title
CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.
  Journal
Dev Cell 44:113-129.e8 (2018)
DOI:10.1016/j.devcel.2017.12.003
Reference
PMID:24582806
  Authors
Pusapati GV, Hughes CE, Dorn KV, Zhang D, Sugianto P, Aravind L, Rohatgi R
  Title
EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia.
  Journal
Dev Cell 28:483-96 (2014)
DOI:10.1016/j.devcel.2014.01.021
Reference
PMID:27779865
  Authors
Rodgers UR, Lanyon-Hogg T, Masumoto N, Ritzefeld M, Burke R, Blagg J, Magee AI, Tate EW
  Title
Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.
  Journal
ACS Chem Biol 11:3256-3262 (2016)
DOI:10.1021/acschembio.6b00896
Related
pathway
oki04120  Ubiquitin mediated proteolysis
KO pathway
ko04340   
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