KEGG   PATHWAY: pavi00270
Entry
pavi00270                   Pathway                                
Name
Cysteine and methionine metabolism - Prunus avium (sweet cherry)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
pavi00270  Cysteine and methionine metabolism
pavi00270

Module
pavi_M00021  Cysteine biosynthesis, serine => cysteine [PATH:pavi00270]
pavi_M00034  Methionine salvage pathway [PATH:pavi00270]
pavi_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:pavi00270]
Other DBs
GO: 0006534 0006555
Organism
Prunus avium (sweet cherry) [GN:pavi]
Gene
110773697  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
110773701  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
110751150  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
110754719  serine acetyltransferase 2-like isoform X1 [KO:K00640] [EC:2.3.1.30]
110759733  cysteine synthase [KO:K01738] [EC:2.5.1.47]
110763757  cysteine synthase, chloroplastic/chromoplastic-like [KO:K01738] [EC:2.5.1.47]
110759786  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
110755015  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
110760389  cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
110751794  L-3-cyanoalanine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
110770046  cystathionine beta-lyase, chloroplastic [KO:K01760] [EC:4.4.1.13]
110768664  homocysteine S-methyltransferase 3-like [KO:K00547] [EC:2.1.1.10]
110763468  homocysteine S-methyltransferase 2 [KO:K00547] [EC:2.1.1.10]
110764110  homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
110774410  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
110766236  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase-like [KO:K00549] [EC:2.1.1.14]
110763881  S-adenosylmethionine synthase 5 [KO:K00789] [EC:2.5.1.6]
110770571  S-adenosylmethionine synthase 2-like [KO:K00789] [EC:2.5.1.6]
110755778  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
110746235  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
110757769  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
110759819  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
110750433  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
110767151  spermine synthase [KO:K00797] [EC:2.5.1.16]
110753233  spermidine synthase [KO:K00797] [EC:2.5.1.16]
110766942  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
110762851  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
110747490  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
110757212  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1-like [KO:K01244] [EC:3.2.2.16]
110757213  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1-like [KO:K01244] [EC:3.2.2.16]
110757220  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1-like [KO:K01244] [EC:3.2.2.16]
110771280  methylthioribose kinase-like [KO:K00899] [EC:2.7.1.100]
110758495  methylthioribose kinase [KO:K00899] [EC:2.7.1.100]
110749197  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
110773320  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 1 isoform X1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
110768657  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 isoform X1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
110768660  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
110753440  uncharacterized protein LOC110753440 [KO:K23977] [EC:2.6.1.117]
110774455  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
110760075  aromatic aminotransferase ISS1 [KO:K00837] [EC:2.6.1.-]
110758899  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
110773968  DNA (cytosine-5)-methyltransferase CMT2-like isoform X1 [KO:K00558] [EC:2.1.1.37]
110762998  DNA (cytosine-5)-methyltransferase CMT3 isoform X1 [KO:K00558] [EC:2.1.1.37]
110748906  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
110759203  uncharacterized protein LOC110759203 [KO:K17398] [EC:2.1.1.37]
110774508  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
110751761  1-aminocyclopropane-1-carboxylate synthase 1 [KO:K20772] [EC:4.4.1.14]
110762457  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
110744374  1-aminocyclopropane-1-carboxylate synthase 8-like [KO:K01762] [EC:4.4.1.14]
110751100  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
110751120  1-aminocyclopropane-1-carboxylate synthase 7 [KO:K01762] [EC:4.4.1.14]
110745926  1-aminocyclopropane-1-carboxylate synthase [KO:K01762] [EC:4.4.1.14]
110748428  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
110750565  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
110764549  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
110750990  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
110771420  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
110764422  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
110764886  aspartokinase 2, chloroplastic [KO:K00928] [EC:2.7.2.4]
110757375  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
110768145  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
110762758  uncharacterized protein LOC110762758 [KO:K00133] [EC:1.2.1.11]
110754705  homoserine kinase [KO:K00872] [EC:2.7.1.39]
110755554  cystathionine gamma-synthase 1, chloroplastic [KO:K27857] [EC:2.5.1.160]
110763327  branched-chain-amino-acid aminotransferase 3, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
110763329  branched-chain-amino-acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
110757248  putative branched-chain-amino-acid aminotransferase 7 isoform X1 [KO:K00826] [EC:2.6.1.42]
110757249  putative branched-chain-amino-acid aminotransferase 7 isoform X1 [KO:K00826] [EC:2.6.1.42]
110757229  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
110750139  branched-chain amino acid aminotransferase 2, chloroplastic isoform X1 [KO:K00826] [EC:2.6.1.42]
110765776  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
110768398  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
110760917  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
110760923  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
110759684  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
110761194  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
110761231  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
110747383  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
110764293  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
110762622  aspartate aminotransferase, chloroplastic [KO:K00811] [EC:2.6.1.1]
110759244  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
110765122  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
110762791  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
110756252  putative D-cysteine desulfhydrase 1, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
110760497  D-cysteine desulfhydrase 2, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
110746721  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial [KO:K05396] [EC:4.4.1.15]
110770561  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
110770576  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
110770583  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
110770601  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
110770603  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
110748944  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
110748679  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
110760310  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
110771779  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
110745262  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
110762351  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
110755010  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
110757231  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
110769413  probable S-sulfocysteine synthase, chloroplastic [KO:K22846] [EC:2.5.1.144]
110772801  D-3-phosphoglycerate dehydrogenase 2, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
110758492  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
110754756  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
110747207  phosphoserine aminotransferase 1, chloroplastic [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01102  O-Phospho-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
pavi00010  Glycolysis / Gluconeogenesis
pavi00250  Alanine, aspartate and glutamate metabolism
pavi00260  Glycine, serine and threonine metabolism
pavi00290  Valine, leucine and isoleucine biosynthesis
pavi00430  Taurine and hypotaurine metabolism
pavi00480  Glutathione metabolism
pavi00620  Pyruvate metabolism
pavi00640  Propanoate metabolism
pavi00770  Pantothenate and CoA biosynthesis
pavi00900  Terpenoid backbone biosynthesis
pavi00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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