KEGG   PATHWAY: pcw04814
Entry
pcw04814                    Pathway                                
Name
Motor proteins - Phascolarctos cinereus (koala)
Class
Cellular Processes; Cell motility
Pathway map
pcw04814  Motor proteins
pcw04814

Organism
Phascolarctos cinereus (koala) [GN:pcw]
Gene
110197364  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
110214974  DYNC2H1; LOW QUALITY PROTEIN: cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
110211570  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
110217562  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
110210459  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
110213038  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
110218547  DYNC2LI1; LOW QUALITY PROTEIN: cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
110221827  dynein light chain 1, cytoplasmic-like [KO:K10418]
110192836  dynein light chain 1, cytoplasmic-like [KO:K10418]
110208992  dynein light chain 1, cytoplasmic-like [KO:K10418]
110210870  LOW QUALITY PROTEIN: dynein light chain 1, cytoplasmic-like [KO:K10418]
110212074  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
110193785  dynein light chain 1, cytoplasmic-like [KO:K10418]
110196609  dynein light chain 1, cytoplasmic-like [KO:K10418]
110222794  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
110193217  DYNLRB2; dynein light chain roadblock-type 2 isoform X1 [KO:K10419]
110216854  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
110208590  DYNLT1; dynein light chain Tctex-type 1 [KO:K10420]
110203147  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
110197933  TCTE3; tctex1 domain-containing protein 3 isoform X1 [KO:K25419]
110209264  TCTEX1D4; tctex1 domain-containing protein 4 [KO:K25420]
110212961  TCTEX1D1; tctex1 domain-containing protein 1 [KO:K25421]
110193504  DNAH3; LOW QUALITY PROTEIN: dynein heavy chain 3, axonemal [KO:K10408]
110197565  DNAH1; LOW QUALITY PROTEIN: dynein heavy chain 1, axonemal [KO:K10408]
110223247  DNAH5; dynein heavy chain 5, axonemal isoform X1 [KO:K10408]
110213247  DNAH7; dynein heavy chain 7, axonemal isoform X1 [KO:K10408]
110194406  DNAH2; dynein heavy chain 2, axonemal isoform X1 [KO:K10408]
110195984  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
110196338  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
110205438  DNAH14; LOW QUALITY PROTEIN: dynein heavy chain 14, axonemal [KO:K10408]
110193881  DNAH9; LOW QUALITY PROTEIN: dynein heavy chain 9, axonemal [KO:K10408]
110217270  DNAH8; LOW QUALITY PROTEIN: dynein heavy chain 8, axonemal [KO:K10408]
110193960  DNAH17; dynein heavy chain 17, axonemal isoform X1 [KO:K10408]
110213051  DNAH11; dynein heavy chain 11, axonemal isoform X1 [KO:K10408]
110196833  DNAH10; LOW QUALITY PROTEIN: dynein heavy chain 10, axonemal [KO:K10408]
110194544  DNAI1; dynein intermediate chain 1, axonemal isoform X1 [KO:K10409]
110219360  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
110209941  WDR63; WD repeat-containing protein 63 isoform X1 [KO:K24722]
110212922  WDR78; WD repeat-containing protein 78 isoform X1 [KO:K24723]
110206344  DNALI1; axonemal dynein light intermediate polypeptide 1 isoform X1 [KO:K10410]
110208354  DNAL1; dynein light chain 1, axonemal isoform X1 [KO:K10411]
110205792  DNAL4; dynein light chain 4, axonemal [KO:K10412]
110220969  DCTN1; LOW QUALITY PROTEIN: dynactin subunit 1 [KO:K04648]
110210976  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
110194562  DCTN3; dynactin subunit 3 [KO:K10425]
110192852  DCTN4; dynactin subunit 4 [KO:K10426]
110202447  DCTN5; dynactin subunit 5 isoform X1 [KO:K10427]
110222990  DCTN6; LOW QUALITY PROTEIN: dynactin subunit 6 [KO:K10428]
110194926  ACTR1A; alpha-centractin isoform X1 [KO:K16575]
110206556  ACTR1B; beta-centractin [KO:K16575]
110208411  ACTR10; actin-related protein 10 [KO:K16576]
110213851  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
110218886  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
110202943  CAPZA2; F-actin-capping protein subunit alpha-2 isoform X1 [KO:K10364]
110198755  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
110214520  BICDL2; BICD family-like cargo adapter 2 [KO:K16756]
110222806  BICDL1; BICD family-like cargo adapter 1 isoform X1 [KO:K16756]
110196406  HOOK3; LOW QUALITY PROTEIN: protein Hook homolog 3 [KO:K16536]
110219406  LOW QUALITY PROTEIN: tubulin alpha-4A chain-like [KO:K07374]
110219478  LOW QUALITY PROTEIN: tubulin alpha-1D chain-like [KO:K07374]
110215276  tubulin alpha-3 chain isoform X1 [KO:K07374]
110215278  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
110219648  tubulin alpha-8 chain isoform X1 [KO:K07374]
110218691  TUBA8; tubulin alpha-8 chain [KO:K07374]
110194029  TUBA1B; tubulin alpha-1B chain [KO:K07374]
110194030  tubulin alpha-1A chain [KO:K07374]
110194031  tubulin alpha-1C chain [KO:K07374]
110205277  TUBB4B; tubulin beta-4B chain [KO:K07375]
110210483  TUBB3; tubulin beta-3 chain [KO:K07375]
110201154  TUBB2A; tubulin beta-2A chain [KO:K07375]
110201159  TUBB2B; tubulin beta-2B chain isoform X1 [KO:K07375]
110199409  TUBB; LOW QUALITY PROTEIN: tubulin beta chain [KO:K07375]
110197482  TUBB4A; tubulin beta-4A chain [KO:K07375]
110205155  TUBB1; tubulin beta-1 chain [KO:K07375]
110207792  TUBB6; tubulin beta-6 chain [KO:K07375]
110198396  tubulin gamma-1 chain-like isoform X1 [KO:K10389]
110198397  TUBG1; tubulin gamma-1 chain [KO:K10389]
110212046  TUBD1; tubulin delta chain isoform X1 [KO:K10390]
110222907  TUBE1; tubulin epsilon chain isoform X1 [KO:K10391]
110210979  KIF5A; LOW QUALITY PROTEIN: kinesin heavy chain [KO:K10396]
110211255  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
110207171  KIF5C; kinesin heavy chain [KO:K10396]
110195476  KLC2; kinesin light chain 2 [KO:K10407]
110201301  KLC4; kinesin light chain 4 [KO:K10407]
110197326  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
110203644  KLC3; kinesin light chain 3 [KO:K10407]
110211697  KIF3A; LOW QUALITY PROTEIN: kinesin-like protein KIF3A [KO:K10394]
110211430  KIF3B; kinesin-like protein KIF3B [KO:K20196]
110199741  KIFAP3; kinesin-associated protein 3 isoform X1 [KO:K25388]
110206515  KIF3C; kinesin-like protein KIF3C [KO:K20197]
110198717  KIF17; kinesin-like protein KIF17 isoform X1 [KO:K20198]
110194287  KIF1C; kinesin-like protein KIF1C isoform X1 [KO:K10392]
110199332  KIF1B; kinesin-like protein KIF1B isoform X1 [KO:K10392]
110210150  KIF1A; LOW QUALITY PROTEIN: kinesin-like protein KIF1A [KO:K10392]
110210002  KIF13B; LOW QUALITY PROTEIN: kinesin-like protein KIF13B [KO:K17914]
110208703  KIF13A; kinesin-like protein KIF13A isoform X1 [KO:K17914]
110219645  KIF14; LOW QUALITY PROTEIN: kinesin-like protein KIF14 [KO:K17915]
110208343  KIF16B; kinesin-like protein KIF16B isoform X1 [KO:K17916]
110223724  STARD9; LOW QUALITY PROTEIN: stAR-related lipid transfer protein 9 [KO:K16491]
110201026  KIF4A; chromosome-associated kinesin KIF4A [KO:K10395]
110193293  KIF7; kinesin-like protein KIF7 isoform X1 [KO:K18806]
110199019  KIF21A; LOW QUALITY PROTEIN: kinesin-like protein KIF21A [KO:K24185]
110219560  KIF21B; kinesin-like protein KIF21B isoform X1 [KO:K24185]
110194549  KIF27; kinesin-like protein KIF27 isoform X1 [KO:K24186]
110192767  KIF11; kinesin-like protein KIF11 [KO:K10398]
110192768  KIF20B; LOW QUALITY PROTEIN: kinesin-like protein KIF20B [KO:K10402]
110220917  KIF20A; kinesin-like protein KIF20A isoform X1 [KO:K10402]
110205543  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
110223067  CENPE; LOW QUALITY PROTEIN: centromere-associated protein E [KO:K11498]
110223091  centromere-associated protein E-like [KO:K11498]
110202025  KIF18A; kinesin-like protein KIF18A isoform X1 [KO:K10401]
110215877  KIF18B; LOW QUALITY PROTEIN: kinesin-like protein KIF18B [KO:K26156]
110219376  KIF19; kinesin-like protein KIF19 isoform X1 [KO:K26157]
110200125  kinesin-like protein KIF19 isoform X1 [KO:K26157]
110217009  KIF9; kinesin-like protein KIF9 isoform X1 [KO:K10397]
110217228  KIF6; kinesin-like protein KIF6 isoform X1 [KO:K10397]
110222014  KIF22; kinesin-like protein KIF22 isoform X1 [KO:K10403]
110205492  KIF26B; kinesin-like protein KIF26B isoform X1 [KO:K10404]
110197363  KIF26A; LOW QUALITY PROTEIN: kinesin-like protein KIF26A [KO:K10404]
110193771  KIF12; kinesin-like protein KIF12 isoform X1 [KO:K10399]
110203305  LOW QUALITY PROTEIN: kinesin-like protein KIF15 [KO:K10400]
110209115  KIF15; LOW QUALITY PROTEIN: kinesin-like protein KIF15 [KO:K10400]
110194578  KIF24; kinesin-like protein KIF24 isoform X1 [KO:K10393]
110212034  KIF2B; LOW QUALITY PROTEIN: kinesin-like protein KIF2B [KO:K10393]
110222295  KIF2A; kinesin-like protein KIF2A isoform X1 [KO:K10393]
110209261  KIF2C; kinesin-like protein KIF2C [KO:K10393]
110217154  KIFC1; kinesin-like protein KIFC1 isoform X1 [KO:K10405]
110192457  KIFC3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
110196942  KIF25; kinesin-like protein KIF25 isoform X1 [KO:K18627]
110192207  MYO1D; unconventional myosin-Id [KO:K10356]
110216972  MYO1G; unconventional myosin-Ig [KO:K10356]
110213269  MYO1B; unconventional myosin-Ib isoform X1 [KO:K10356]
110222148  MYO1C; unconventional myosin-Ic isoform X1 [KO:K10356]
110210958  MYO1A; unconventional myosin-Ia [KO:K10356]
110205371  MYO1E; unconventional myosin-Ie isoform X1 [KO:K10356]
110222764  MYO1H; LOW QUALITY PROTEIN: unconventional myosin-Ih [KO:K10356]
110202137  MYO1F; LOW QUALITY PROTEIN: unconventional myosin-If [KO:K10356]
110202195  MYO3A; myosin-IIIa [KO:K08834] [EC:2.7.11.1]
110211556  MYO3B; myosin-IIIb [KO:K08834] [EC:2.7.11.1]
110204825  MYO5A; unconventional myosin-Va isoform X1 [KO:K10357]
110198149  MYO5B; unconventional myosin-Vb isoform X1 [KO:K10357]
110206982  MYO5C; LOW QUALITY PROTEIN: unconventional myosin-Vc [KO:K10357]
110217683  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
110210539  MYO7A; unconventional myosin-VIIa isoform X1 [KO:K10359]
110194703  MYO7B; unconventional myosin-VIIb isoform X1 [KO:K21868]
110196132  MYO9B; unconventional myosin-IXb isoform X1 [KO:K10360]
110215420  MYO9A; LOW QUALITY PROTEIN: unconventional myosin-IXa [KO:K10360]
110223241  MYO10; unconventional myosin-X isoform X1 [KO:K12559]
110194820  MYO15A; LOW QUALITY PROTEIN: unconventional myosin-XV [KO:K10361]
110219388  MYO15B; myosin XVB isoform X1 [KO:K10361]
110196704  MYO16; LOW QUALITY PROTEIN: unconventional myosin-XVI [KO:K17481]
110192232  MYO18A; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
110215277  MYO18B; LOW QUALITY PROTEIN: unconventional myosin-XVIIIb [KO:K10362]
110212022  MYO19; unconventional myosin-XIX isoform X1 [KO:K25838]
110193871  myosin-1 isoform X1 [KO:K24220]
110193868  myosin-2 [KO:K24220]
110193899  myosin-3 isoform X1 [KO:K24220]
110216803  MYH7B; myosin-7B isoform X1 [KO:K24220]
110193869  myosin-4 isoform X1 [KO:K24220]
110193917  myosin-13 [KO:K24220]
110193870  myosin-8 isoform X1 [KO:K24220]
110193568  MYH7; myosin-7 [KO:K17751]
110193748  MYH6; myosin-6 [KO:K17751]
110194269  MYH10; LOW QUALITY PROTEIN: myosin-10 [KO:K10352]
110197743  MYH14; myosin-14 [KO:K10352]
110205723  MYH9; LOW QUALITY PROTEIN: myosin-9 [KO:K10352]
110218844  MYH11; myosin-11 isoform X1 [KO:K10352]
110223301  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
110217119  MYL3; myosin light chain 3 [KO:K12749]
110215795  MYL4; myosin light chain 4 isoform X1 [KO:K12750]
110197542  myosin light polypeptide 6-like [KO:K12751]
110210918  MYL6B; myosin light chain 6B [KO:K12751]
110210919  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
110196868  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
110221051  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
110206410  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
110216721  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
110221306  MYL10; myosin regulatory light chain 10 [KO:K12756]
110197087  MYL12B; myosin regulatory light chain 12B [KO:K12757]
110197071  myosin regulatory light chain 12B-like [KO:K12757]
110223139  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
110195421  actin, alpha skeletal muscle-like [KO:K10354]
110217891  ACTA1; actin, alpha skeletal muscle [KO:K10354]
110198957  ACTA2; actin, aortic smooth muscle [KO:K12313]
110214160  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
110222638  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
110218220  ACTG1; actin, cytoplasmic 2 [KO:K05692]
110205635  actin, cytoplasmic 1-like [KO:K05692]
110214034  LOW QUALITY PROTEIN: actin, cytoplasmic type 5-like [KO:K05692]
110223114  ACTB; actin, cytoplasmic 1 [KO:K05692]
110197564  TNNC1; LOW QUALITY PROTEIN: troponin C, slow skeletal and cardiac muscles [KO:K05865]
110219649  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
110220259  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
110193718  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
110197139  TNNI2; troponin I, fast skeletal muscle isoform X1 [KO:K12043]
110197161  TNNT3; troponin T, fast skeletal muscle [KO:K12046]
110220013  TNNI3; troponin I, cardiac muscle [KO:K12044]
110219553  TNNT2; LOW QUALITY PROTEIN: troponin T, cardiac muscle [KO:K12045]
110195734  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
110201444  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
110211987  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
110196120  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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