KEGG   PATHWAY: plep00270
Entry
plep00270                   Pathway                                
Name
Cysteine and methionine metabolism - Plectropomus leopardus (leopard coralgrouper)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
plep00270  Cysteine and methionine metabolism
plep00270

Module
plep_M00034  Methionine salvage pathway [PATH:plep00270]
plep_M00035  Methionine degradation [PATH:plep00270]
plep_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:plep00270]
Other DBs
GO: 0006534 0006555
Organism
Plectropomus leopardus (leopard coralgrouper) [GN:plep]
Gene
121966044  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
121941048  kynurenine--oxoglutarate transaminase 3-like isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
121959701  kyat1; kynurenine--oxoglutarate transaminase 1 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
121959912  kynurenine--oxoglutarate transaminase 1-like [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
121937997  kynurenine--oxoglutarate transaminase 3-like [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
121962760  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
121944080  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
121944246  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
121944247  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
121944389  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
121940970  zgc:172121; LOW QUALITY PROTEIN: homocysteine S-methyltransferase [KO:K00547] [EC:2.1.1.10]
121959124  mtr; methionine synthase [KO:K00548] [EC:2.1.1.13]
121958443  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
121959669  mat2aa; methionine adenosyltransferase II, alpha a [KO:K00789] [EC:2.5.1.6]
121954429  mat1a; S-adenosylmethionine synthase isoform X1 [KO:K00789] [EC:2.5.1.6]
121944593  mat2ab; S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
121939138  methionine adenosyltransferase 2 subunit beta-like [KO:K00789] [EC:2.5.1.6]
121955210  amd1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
121946992  srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
121952586  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
121952587  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
121942550  S-methyl-5'-thioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]
121948764  lacc1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
121941789  mri1; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
121943209  methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]
121966438  enolase-phosphatase E1-like [KO:K09880] [EC:3.1.3.77]
121960246  enoph1; LOW QUALITY PROTEIN: enolase-phosphatase E1 [KO:K09880] [EC:3.1.3.77]
121953349  adi1; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
121950190  tat; tyrosine aminotransferase [KO:K00815] [EC:2.6.1.5]
121943552  il4i1; L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
121944726  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
121962097  LOW QUALITY PROTEIN: L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
121962098  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
121962508  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
121962509  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
121953867  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
121957142  dnmt1; DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
121953434  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
121955594  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
121946515  LOW QUALITY PROTEIN: uncharacterized protein LOC121946515 [KO:K17399] [EC:2.1.1.37]
121946793  dnmt3bb.1; DNA (cytosine-5)-methyltransferase 3B isoform X1 [KO:K17399] [EC:2.1.1.37]
121946977  dnmt3ba; DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a [KO:K17399] [EC:2.1.1.37]
121946939  ahcyl1; S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
121960624  ahcy; adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
121950000  S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
121961401  ahcyl2b; adenosylhomocysteinase like 2b isoform X1 [KO:K01251] [EC:3.13.2.1]
121956352  S-adenosylhomocysteine hydrolase-like protein 1 [KO:K01251] [EC:3.13.2.1]
121961117  bcat1; branched-chain-amino-acid aminotransferase, cytosolic [KO:K00826] [EC:2.6.1.42]
121956470  bcat2; branched-chain-amino-acid aminotransferase, mitochondrial [KO:K00826] [EC:2.6.1.42]
121960191  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
121960193  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
121954449  gclc; glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]
121964028  gclm; glutamate--cysteine ligase regulatory subunit [KO:K11205]
121946610  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
121947025  glutathione synthetase-like [KO:K21456] [EC:6.3.2.3]
121944996  cdo1; cysteine dioxygenase type 1 [KO:K00456] [EC:1.13.11.20]
121966597  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
121954623  got1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
121944956  got1l1; putative aspartate aminotransferase, cytoplasmic 2 [KO:K14454] [EC:2.6.1.1]
121956984  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
121940658  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
121942659  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
121956945  LOW QUALITY PROTEIN: 3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
121957083  3-mercaptopyruvate sulfurtransferase-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
121950079  L-lactate dehydrogenase C chain [KO:K00016] [EC:1.1.1.27]
121961319  ldhba; L-lactate dehydrogenase B-A chain [KO:K00016] [EC:1.1.1.27]
121950728  ldha; L-lactate dehydrogenase A chain [KO:K00016] [EC:1.1.1.27]
121954839  mdh1ab; malate dehydrogenase 1Ab, NAD (soluble) [KO:K00025] [EC:1.1.1.37]
121945612  mdh2; malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
121954146  LOW QUALITY PROTEIN: L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
121944115  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
121949283  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
121944369  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
plep00010  Glycolysis / Gluconeogenesis
plep00250  Alanine, aspartate and glutamate metabolism
plep00260  Glycine, serine and threonine metabolism
plep00290  Valine, leucine and isoleucine biosynthesis
plep00430  Taurine and hypotaurine metabolism
plep00480  Glutathione metabolism
plep00620  Pyruvate metabolism
plep00640  Propanoate metabolism
plep00770  Pantothenate and CoA biosynthesis
plep00900  Terpenoid backbone biosynthesis
plep00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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