KEGG   PATHWAY: pon00983
Entry
pon00983                    Pathway                                
Name
Drug metabolism - other enzymes - Pongo abelii (Sumatran orangutan)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
pon00983  Drug metabolism - other enzymes
pon00983

Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100447935  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
100443958  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
100442769  inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
100443279  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X3 [KO:K00088] [EC:1.1.1.205]
129048063  LOW QUALITY PROTEIN: inosine-5'-monophosphate dehydrogenase 1-like [KO:K00088] [EC:1.1.1.205]
100169736  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
100172405  TPMT; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
100458866  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
100454383  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
100445808  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
100174711  CES1; liver carboxylesterase 1 precursor [KO:K01044] [EC:3.1.1.1]
100451021  liver carboxylesterase 1-like isoform X1 [KO:K01044] [EC:3.1.1.1]
103892689  CES2; cocaine esterase isoform X1 [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
100431215  cocaine esterase [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
100445423  UDP-glucuronosyltransferase 2B4-like isoform X1 [KO:K00699] [EC:2.4.1.17]
100171521  UGT2B7; UDP-glucuronosyltransferase 2B7 precursor [KO:K00699] [EC:2.4.1.17]
100172533  UGT1A3; UDP-glucuronosyltransferase 1-3 precursor [KO:K00699] [EC:2.4.1.17]
100174202  UGT2A3; UDP-glucuronosyltransferase 2A3 precursor [KO:K00699] [EC:2.4.1.17]
100441531  UDP-glucuronosyltransferase 2B10 isoform X1 [KO:K00699] [EC:2.4.1.17]
100446928  UGT2B4; UDP-glucuronosyltransferase 2B4 isoform X4 [KO:K00699] [EC:2.4.1.17]
100447782  UDP-glucuronosyltransferase 2A1 isoform X3 [KO:K00699] [EC:2.4.1.17]
100460599  UDP-glucuronosyltransferase 2B17 isoform X1 [KO:K00699] [EC:2.4.1.17]
100444573  UDP-glucuronosyltransferase 2B30 isoform X1 [KO:K00699] [EC:2.4.1.17]
100446313  UDP-glucuronosyltransferase 2B11 isoform X2 [KO:K00699] [EC:2.4.1.17]
100461334  UGT2B15; UDP-glucuronosyltransferase 2B15 isoform X1 [KO:K00699] [EC:2.4.1.17]
100447519  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1A9 [KO:K00699] [EC:2.4.1.17]
100431382  UDP-glucuronosyltransferase 1A7 [KO:K00699] [EC:2.4.1.17]
100442747  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
100173726  GUSB; beta-glucuronidase precursor [KO:K01195] [EC:3.2.1.31]
100439268  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
100457728  LOW QUALITY PROTEIN: beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
100436782  cytochrome P450 3A8 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
100443805  CDA; cytidine deaminase isoform X2 [KO:K01489] [EC:3.5.4.5]
100173131  DPYD; dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
100438145  DPYS; dihydropyrimidinase isoform X1 [KO:K01464] [EC:3.5.2.2]
100172385  UPB1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
100457048  cytochrome P450 2A6 [KO:K17683] [EC:1.14.14.-]
100459345  UPP2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
100439965  UPP1; uridine phosphorylase 1 isoform X2 [KO:K00757] [EC:2.4.2.3]
100173256  UCK1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
100445813  UCKL1; uridine-cytidine kinase-like 1 isoform X9 [KO:K00876] [EC:2.7.1.48]
100433829  UCK2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
100444680  TK1; thymidine kinase, cytosolic isoform X2 [KO:K00857] [EC:2.7.1.21]
100458852  TK2; thymidine kinase 2, mitochondrial isoform X2 [KO:K00857] [EC:2.7.1.21]
100173867  UMPS; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
100437591  CMPK1; UMP-CMP kinase isoform X1 [KO:K13800] [EC:2.7.4.14]
100172956  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
100172878  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
100435953  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X9 [KO:K10808] [EC:1.17.4.1]
100456929  NME6; nucleoside diphosphate kinase 6 isoform X2 [KO:K00940] [EC:2.7.4.6]
100174205  NME2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
100448612  NME7; nucleoside diphosphate kinase 7 isoform X4 [KO:K00940] [EC:2.7.4.6]
100433847  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
100437328  NME4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
103892831  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
100456894  DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X2 [KO:K01520] [EC:3.6.1.23]
100461693  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
100435042  NAT1; arylamine N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
129060827  NAT2; arylamine N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
100173813  CYP2E1; cytochrome P450 2E1 precursor [KO:K07415] [EC:1.14.14.-]
100174562  GSTM2; glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
100437206  MGST3; glutathione S-transferase 3, mitochondrial isoform X2 [KO:K00799] [EC:2.5.1.18]
100437569  MGST1; microsomal glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
100439198  glutathione S-transferase theta-1 isoform X2 [KO:K00799] [EC:2.5.1.18]
100445078  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
100445448  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
100446578  glutathione S-transferase A3 isoform X1 [KO:K00799] [EC:2.5.1.18]
100447725  GSTO1; glutathione S-transferase omega-1 isoform X2 [KO:K00799] [EC:2.5.1.18]
100448103  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
100450689  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
100450954  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
100452892  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
100453263  GSTM5; glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
100453622  GSTM1; glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
100454483  GSTM4; glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
100461022  glutathione S-transferase theta-2B isoform X1 [KO:K00799] [EC:2.5.1.18]
100445831  LOW QUALITY PROTEIN: glutathione S-transferase A5 [KO:K00799] [EC:2.5.1.18]
100439941  glutathione S-transferase theta-4-like isoform X2 [KO:K00799] [EC:2.5.1.18]
100450224  LOW QUALITY PROTEIN: glutathione S-transferase A3 [KO:K00799] [EC:2.5.1.18]
100451109  glutathione S-transferase theta-4 isoform X1 [KO:K00799] [EC:2.5.1.18]
100449856  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
100450378  GSTT2B; LOW QUALITY PROTEIN: glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
100432722  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
100449495  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
100936843  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
134761157  LOW QUALITY PROTEIN: glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
134761159  glutathione S-transferase theta-2-like [KO:K00799] [EC:2.5.1.18]
134761188  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
134761199  glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
134759367  glutathione S-transferase theta-4 isoform X1 [KO:K00799] [EC:2.5.1.18]
100174544  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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