Entry Name Bacterial invasion of epithelial cells - Pteronotus mesoamericanus (Parnell's mustached bat)
Description Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.
Class Human Diseases; Infectious disease: bacterialBRITE hierarchy
Pathway map ppam05100 Bacterial invasion of epithelial cells
Ortholog table Organism Pteronotus mesoamericanus (Parnell's mustached bat) [GN:
ppam ]
Gene 129061895 ARHGAP10; rho GTPase-activating protein 10 isoform X1 [KO:K13736 ]
129074969 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
129069407 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
129074590 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
129075675 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
129076577 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
129088291 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
129069153 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
129068140 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
129063293 WASL; actin nucleation-promoting factor WASL isoform X1 [KO:K23612 ]
129079273 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
129075188 BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726 ]
129075654 MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728 ]
129075685 ARHGEF26; rho guanine nucleotide exchange factor 26 isoform X1 [KO:K13744 ]
129068909 ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366 ]
129070644 ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
Reference Authors Mostowy S, Cossart P
Title Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game.
Journal Reference Authors Hauck CR, Ohlsen K
Title Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.
Journal Reference Authors Wang B, Li S, Dedhar S, Cleary PP
Title Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.
Journal Reference Authors Matsumoto H, Young GM
Title Translocated effectors of Yersinia.
Journal Reference Authors McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title Salmonella takes control: effector-driven manipulation of the host.
Journal Reference Authors Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C
Title A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.
Journal Related KO pathway LinkDB All DBs
